FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083894071> ?p ?o ?g. }

• W3083894071 endingPage "152583" @default.
• W3083894071 startingPage "152583" @default.
• W3083894071 abstract "Extracellular matrix (ECM) exerts a major role in maintaining the structure and developmental processes of tissues. To form the tubular basement membrane in the kidney, sulfate proteoglycans, collagen, laminin, fibronectin, and other glycoproteins congregate in the ECM. As an insecticide, diazinon (DZN) may alter the proportion of ECM by cholinesterase activity inhibition and oxidative stress. The naturally, alpha-lipoic acid (ALA) plays an effective and therapeutic role in the treatment of toxicities and diseases in the body. In the current study, an attempt was made to evaluate the impacts of alpha-lipoic acid on the distribution of fibronectin and laminin in the renal tubules of male Wistar rats following exposure to diazinon. In this study, the animal groups comprised 30 adult male Wistar rats (almost three months old) randomly distributed into the following groups; control, DZN (40 mg/kg), DZN + ALA (40 mg/kg+100 mg/kg), ALA (100 mg/kg), and sham. The rats were anesthetized after six weeks. Blood sampling was performed, and kidneys were removed for immunohistochemistry study. Diazinon reduced the distribution of fibronectin and laminin and significantly inhibited cholinesterase activity in the renal tubules. Furthermore, urea and creatinine levels were higher in diazinon than in other groups. ALA in the co-treatment group enhanced cholinesterase activity and distribution of both glycoproteins in the renal tubules. Urea and creatinine levels were meaningfully diminished in the DZN + ALA group. The nephrotoxic effect of diazinon in vivo was the reduced distribution of laminin and fibronectin, probably induced by cholinesterase activity inhibition. As an antioxidant with specific properties, ALA reduces the nephrotoxic effects of diazinon by multifarious mechanisms." @default.
• W3083894071 created "2020-09-14" @default.
• W3083894071 creator A5003597895 @default.
• W3083894071 creator A5050273143 @default.
• W3083894071 creator A5070792726 @default.
• W3083894071 creator A5085667470 @default.
• W3083894071 date "2020-11-01" @default.
• W3083894071 modified "2023-09-26" @default.
• W3083894071 title "The protective role of alpha-lipoic acid on the appearance of fibronectin and laminin in renal tubules following diazinon exposure: An experimental immunohistochemical study" @default.
• W3083894071 cites W1752616034 @default.
• W3083894071 cites W1977263350 @default.
• W3083894071 cites W1984831910 @default.
• W3083894071 cites W1996111288 @default.
• W3083894071 cites W2007239448 @default.
• W3083894071 cites W2021243139 @default.
• W3083894071 cites W2032284482 @default.
• W3083894071 cites W2052509859 @default.
• W3083894071 cites W2056385648 @default.
• W3083894071 cites W2064023016 @default.
• W3083894071 cites W2064678025 @default.
• W3083894071 cites W2080477532 @default.
• W3083894071 cites W2087953841 @default.
• W3083894071 cites W2094316487 @default.
• W3083894071 cites W2104529598 @default.
• W3083894071 cites W2106614841 @default.
• W3083894071 cites W2134056059 @default.
• W3083894071 cites W2147094935 @default.
• W3083894071 cites W2150762383 @default.
• W3083894071 cites W2156813826 @default.
• W3083894071 cites W2288769497 @default.
• W3083894071 cites W2443773849 @default.
• W3083894071 cites W2537568422 @default.
• W3083894071 cites W2607477640 @default.
• W3083894071 cites W2748621598 @default.
• W3083894071 cites W2963203722 @default.
• W3083894071 cites W4211134041 @default.
• W3083894071 doi "https://doi.org/10.1016/j.tox.2020.152583" @default.
• W3083894071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32911022" @default.
• W3083894071 hasPublicationYear "2020" @default.
• W3083894071 type Work @default.
• W3083894071 sameAs 3083894071 @default.
• W3083894071 citedByCount "1" @default.
• W3083894071 countsByYear W30838940712022 @default.
• W3083894071 crossrefType "journal-article" @default.
• W3083894071 hasAuthorship W3083894071A5003597895 @default.
• W3083894071 hasAuthorship W3083894071A5050273143 @default.
• W3083894071 hasAuthorship W3083894071A5070792726 @default.
• W3083894071 hasAuthorship W3083894071A5085667470 @default.
• W3083894071 hasConcept C134018914 @default.
• W3083894071 hasConcept C141071460 @default.
• W3083894071 hasConcept C142724271 @default.
• W3083894071 hasConcept C161176658 @default.
• W3083894071 hasConcept C185592680 @default.
• W3083894071 hasConcept C189165786 @default.
• W3083894071 hasConcept C204232928 @default.
• W3083894071 hasConcept C2775944032 @default.
• W3083894071 hasConcept C2776151105 @default.
• W3083894071 hasConcept C2779814568 @default.
• W3083894071 hasConcept C2779842916 @default.
• W3083894071 hasConcept C2780091579 @default.
• W3083894071 hasConcept C2910140794 @default.
• W3083894071 hasConcept C2991844318 @default.
• W3083894071 hasConcept C49453240 @default.
• W3083894071 hasConcept C55493867 @default.
• W3083894071 hasConcept C64943373 @default.
• W3083894071 hasConcept C6557445 @default.
• W3083894071 hasConcept C71924100 @default.
• W3083894071 hasConcept C86492073 @default.
• W3083894071 hasConcept C86803240 @default.
• W3083894071 hasConceptScore W3083894071C134018914 @default.
• W3083894071 hasConceptScore W3083894071C141071460 @default.
• W3083894071 hasConceptScore W3083894071C142724271 @default.
• W3083894071 hasConceptScore W3083894071C161176658 @default.
• W3083894071 hasConceptScore W3083894071C185592680 @default.
• W3083894071 hasConceptScore W3083894071C189165786 @default.
• W3083894071 hasConceptScore W3083894071C204232928 @default.
• W3083894071 hasConceptScore W3083894071C2775944032 @default.
• W3083894071 hasConceptScore W3083894071C2776151105 @default.
• W3083894071 hasConceptScore W3083894071C2779814568 @default.
• W3083894071 hasConceptScore W3083894071C2779842916 @default.
• W3083894071 hasConceptScore W3083894071C2780091579 @default.
• W3083894071 hasConceptScore W3083894071C2910140794 @default.
• W3083894071 hasConceptScore W3083894071C2991844318 @default.
• W3083894071 hasConceptScore W3083894071C49453240 @default.
• W3083894071 hasConceptScore W3083894071C55493867 @default.
• W3083894071 hasConceptScore W3083894071C64943373 @default.
• W3083894071 hasConceptScore W3083894071C6557445 @default.
• W3083894071 hasConceptScore W3083894071C71924100 @default.
• W3083894071 hasConceptScore W3083894071C86492073 @default.
• W3083894071 hasConceptScore W3083894071C86803240 @default.
• W3083894071 hasLocation W30838940711 @default.
• W3083894071 hasOpenAccess W3083894071 @default.
• W3083894071 hasPrimaryLocation W30838940711 @default.
• W3083894071 hasRelatedWork W1995440302 @default.
• W3083894071 hasRelatedWork W1995752079 @default.
• W3083894071 hasRelatedWork W2008535100 @default.
• W3083894071 hasRelatedWork W2206340059 @default.
• W3083894071 hasRelatedWork W2352011868 @default.

• next