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- W3083934582 endingPage "6582" @default.
- W3083934582 startingPage "6582" @default.
- W3083934582 abstract "Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been widely proven as a promising treatment strategy in immune therapeutics. The extraordinary advantages associated with mRNA vaccines, including their high efficacy, a relatively low severity of side effects, and low attainment costs, have enabled them to become prevalent in pre-clinical and clinical trials against various infectious diseases and cancers. Recent technological advancements have alleviated some issues that hinder mRNA vaccine development, such as low efficiency that exist in both gene translation and in vivo deliveries. mRNA immunogenicity can also be greatly adjusted as a result of upgraded technologies. In this review, we have summarized details regarding the optimization of mRNA vaccines, and the underlying biological mechanisms of this form of vaccines. Applications of mRNA vaccines in some infectious diseases and cancers are introduced. It also includes our prospections for mRNA vaccine applications in diseases caused by bacterial pathogens, such as tuberculosis. At the same time, some suggestions for future mRNA vaccine development about storage methods, safety concerns, and personalized vaccine synthesis can be found in the context." @default.
- W3083934582 created "2020-09-14" @default.
- W3083934582 creator A5004646689 @default.
- W3083934582 creator A5015794368 @default.
- W3083934582 creator A5047626340 @default.
- W3083934582 creator A5086175992 @default.
- W3083934582 date "2020-09-09" @default.
- W3083934582 modified "2023-10-16" @default.
- W3083934582 title "mRNA Vaccine Era—Mechanisms, Drug Platform and Clinical Prospection" @default.
- W3083934582 cites W1420726270 @default.
- W3083934582 cites W1522802573 @default.
- W3083934582 cites W1531431054 @default.
- W3083934582 cites W1828166467 @default.
- W3083934582 cites W1833523230 @default.
- W3083934582 cites W1895187084 @default.
- W3083934582 cites W1963706689 @default.
- W3083934582 cites W1965493633 @default.
- W3083934582 cites W1966322307 @default.
- W3083934582 cites W1969072247 @default.
- W3083934582 cites W1971250275 @default.
- W3083934582 cites W1971916935 @default.
- W3083934582 cites W1972263472 @default.
- W3083934582 cites W1976118264 @default.
- W3083934582 cites W1980315923 @default.
- W3083934582 cites W1981552958 @default.
- W3083934582 cites W1981816112 @default.
- W3083934582 cites W1984815734 @default.
- W3083934582 cites W1986939156 @default.
- W3083934582 cites W1988620094 @default.
- W3083934582 cites W1990093169 @default.
- W3083934582 cites W1991064719 @default.
- W3083934582 cites W1992513864 @default.
- W3083934582 cites W1993844364 @default.
- W3083934582 cites W1994310269 @default.
- W3083934582 cites W1994674548 @default.
- W3083934582 cites W1995580450 @default.
- W3083934582 cites W2000136129 @default.
- W3083934582 cites W2006652125 @default.
- W3083934582 cites W2009042469 @default.
- W3083934582 cites W2011458181 @default.
- W3083934582 cites W2014495927 @default.
- W3083934582 cites W2014992495 @default.
- W3083934582 cites W2017515700 @default.
- W3083934582 cites W2021978074 @default.
- W3083934582 cites W2025980739 @default.
- W3083934582 cites W2026083914 @default.
- W3083934582 cites W2026576181 @default.
- W3083934582 cites W2029708918 @default.
- W3083934582 cites W2031745114 @default.
- W3083934582 cites W2033322939 @default.
- W3083934582 cites W2038788801 @default.
- W3083934582 cites W2039249037 @default.
- W3083934582 cites W2039422212 @default.
- W3083934582 cites W2039551908 @default.
- W3083934582 cites W2041617433 @default.
- W3083934582 cites W2044439943 @default.
- W3083934582 cites W2051091654 @default.
- W3083934582 cites W2051665875 @default.
- W3083934582 cites W2054298563 @default.
- W3083934582 cites W2055351480 @default.
- W3083934582 cites W2057294180 @default.
- W3083934582 cites W2058492139 @default.
- W3083934582 cites W2058647478 @default.
- W3083934582 cites W2061499228 @default.
- W3083934582 cites W2062398277 @default.
- W3083934582 cites W2064864270 @default.
- W3083934582 cites W2065905166 @default.
- W3083934582 cites W2066847748 @default.
- W3083934582 cites W2069390230 @default.
- W3083934582 cites W2071136305 @default.
- W3083934582 cites W2071302752 @default.
- W3083934582 cites W2072499238 @default.
- W3083934582 cites W2077219861 @default.
- W3083934582 cites W2079696222 @default.
- W3083934582 cites W2083665908 @default.
- W3083934582 cites W2083958143 @default.
- W3083934582 cites W2084263949 @default.
- W3083934582 cites W2085865810 @default.
- W3083934582 cites W2086245096 @default.
- W3083934582 cites W2087497808 @default.
- W3083934582 cites W2091436625 @default.
- W3083934582 cites W2095950646 @default.
- W3083934582 cites W2108706633 @default.
- W3083934582 cites W2109280271 @default.
- W3083934582 cites W2110083155 @default.
- W3083934582 cites W2122292621 @default.
- W3083934582 cites W2125677437 @default.
- W3083934582 cites W2126865761 @default.
- W3083934582 cites W2127576136 @default.
- W3083934582 cites W2131459517 @default.
- W3083934582 cites W2137633461 @default.
- W3083934582 cites W2139511604 @default.
- W3083934582 cites W2147621714 @default.
- W3083934582 cites W2150490625 @default.
- W3083934582 cites W2153049488 @default.
- W3083934582 cites W2162165801 @default.
- W3083934582 cites W2162541845 @default.
- W3083934582 cites W2162970812 @default.