Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083958045> ?p ?o ?g. }
- W3083958045 endingPage "6622" @default.
- W3083958045 startingPage "6622" @default.
- W3083958045 abstract "Androgen receptor (AR)-mediated signaling is essential for the growth and differentiation of the normal prostate and is the primary target for androgen deprivation therapy in prostate cancer. Tat interactive protein 60 kDa (Tip60) is a histone acetyltransferase that is critical for AR activation. It is well known that cancer cells rewire their metabolic pathways in order to sustain aberrant proliferation. Growing evidence demonstrates that the AR and Tip60 modulate key metabolic processes to promote the survival of prostate cancer cells, in addition to their classical roles. AR activation enhances glucose metabolism, including glycolysis, tricarboxylic acid cycle and oxidative phosphorylation, as well as lipid metabolism in prostate cancer. The AR also interacts with other metabolic regulators, including calcium/calmodulin-dependent kinase kinase 2 and mammalian target of rapamycin. Several studies have revealed the roles of Tip60 in determining cell fate indirectly by modulating metabolic regulators, such as c-Myc, hypoxia inducible factor 1α (HIF-1α) and p53 in various cancer types. Furthermore, Tip60 has been shown to regulate the activity of key enzymes in gluconeogenesis and glycolysis directly through acetylation. Overall, both the AR and Tip60 are master metabolic regulators that mediate cellular energy metabolism in prostate cancer, providing a framework for the development of novel therapeutic targets in androgen-dependent prostate cancer." @default.
- W3083958045 created "2020-09-14" @default.
- W3083958045 creator A5030945420 @default.
- W3083958045 creator A5059081442 @default.
- W3083958045 creator A5081167981 @default.
- W3083958045 date "2020-09-10" @default.
- W3083958045 modified "2023-10-16" @default.
- W3083958045 title "Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer" @default.
- W3083958045 cites W1501286679 @default.
- W3083958045 cites W1551686296 @default.
- W3083958045 cites W1574675143 @default.
- W3083958045 cites W1831610625 @default.
- W3083958045 cites W1879352431 @default.
- W3083958045 cites W1904433804 @default.
- W3083958045 cites W1919512980 @default.
- W3083958045 cites W1964186830 @default.
- W3083958045 cites W1972739162 @default.
- W3083958045 cites W1976632546 @default.
- W3083958045 cites W1982545065 @default.
- W3083958045 cites W1991995900 @default.
- W3083958045 cites W2004170579 @default.
- W3083958045 cites W2007844375 @default.
- W3083958045 cites W2008715871 @default.
- W3083958045 cites W2014269608 @default.
- W3083958045 cites W2018734911 @default.
- W3083958045 cites W2025838418 @default.
- W3083958045 cites W2026102934 @default.
- W3083958045 cites W2027397115 @default.
- W3083958045 cites W2033958147 @default.
- W3083958045 cites W2038324148 @default.
- W3083958045 cites W2041997083 @default.
- W3083958045 cites W2048333904 @default.
- W3083958045 cites W2052612645 @default.
- W3083958045 cites W2055063491 @default.
- W3083958045 cites W2060628991 @default.
- W3083958045 cites W2062211259 @default.
- W3083958045 cites W2066379425 @default.
- W3083958045 cites W2068385489 @default.
- W3083958045 cites W2070736740 @default.
- W3083958045 cites W2078693224 @default.
- W3083958045 cites W2079081853 @default.
- W3083958045 cites W2085609235 @default.
- W3083958045 cites W2085872107 @default.
- W3083958045 cites W2086630627 @default.
- W3083958045 cites W2094506191 @default.
- W3083958045 cites W2095561162 @default.
- W3083958045 cites W2097259163 @default.
- W3083958045 cites W2102322990 @default.
- W3083958045 cites W2105250121 @default.
- W3083958045 cites W2106318552 @default.
- W3083958045 cites W2107372115 @default.
- W3083958045 cites W2108301486 @default.
- W3083958045 cites W2110103733 @default.
- W3083958045 cites W2110894784 @default.
- W3083958045 cites W2113334939 @default.
- W3083958045 cites W2114704791 @default.
- W3083958045 cites W2127360534 @default.
- W3083958045 cites W2127987668 @default.
- W3083958045 cites W2136344158 @default.
- W3083958045 cites W2137960344 @default.
- W3083958045 cites W2140777784 @default.
- W3083958045 cites W2144954025 @default.
- W3083958045 cites W2146027649 @default.
- W3083958045 cites W2146885685 @default.
- W3083958045 cites W2150097377 @default.
- W3083958045 cites W2154541005 @default.
- W3083958045 cites W2156943914 @default.
- W3083958045 cites W2157230165 @default.
- W3083958045 cites W2163958526 @default.
- W3083958045 cites W2172829973 @default.
- W3083958045 cites W2194294271 @default.
- W3083958045 cites W2204399474 @default.
- W3083958045 cites W2220221033 @default.
- W3083958045 cites W2234823340 @default.
- W3083958045 cites W2342953417 @default.
- W3083958045 cites W2397465129 @default.
- W3083958045 cites W2431898039 @default.
- W3083958045 cites W2554916046 @default.
- W3083958045 cites W2581267196 @default.
- W3083958045 cites W2599085091 @default.
- W3083958045 cites W2738571701 @default.
- W3083958045 cites W2767348608 @default.
- W3083958045 cites W2768762463 @default.
- W3083958045 cites W2768768130 @default.
- W3083958045 cites W2770957979 @default.
- W3083958045 cites W2780918947 @default.
- W3083958045 cites W2785632856 @default.
- W3083958045 cites W2797332465 @default.
- W3083958045 cites W2799423581 @default.
- W3083958045 cites W2803341036 @default.
- W3083958045 cites W2889646458 @default.
- W3083958045 cites W2900888169 @default.
- W3083958045 cites W2905965925 @default.
- W3083958045 cites W2919051910 @default.
- W3083958045 cites W2919189760 @default.
- W3083958045 cites W2982405104 @default.
- W3083958045 cites W590084404 @default.
- W3083958045 doi "https://doi.org/10.3390/ijms21186622" @default.