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• W3084046500 abstract "This study was designed to assess bisphenol A (BPA)-induced vascular toxicity, the effectiveness of green tea extract and epigallocatechin gallate (EGCG) against BPA toxicity, and possible underlying mechanisms. In isolated rat aorta, contractile and relaxant responses as well as malondialdehyde levels were evaluated. Cell viability and effects on the protein levels of apoptotic (bax, bcl2, and caspase-3), autophagic (LC3), and cell adhesion molecules were calculated using the MTT method and western blotting in human umbilical vein endothelial cells (HUVECs). BPA increased aorta MDA levels (p < .0001) and decreased vascular responses to KCl [20 and 40 mM (p < .0001), 80 mM (p < .001)], phenylephrine [10−8, 10−6, and 10−5 M (p < .001), 10−7 and 10−4 M (p < .0001)], and acetylcholine [10−6 M (p < .01), 10−5 and 10−4 M (p < .0001)]. In HUVECs, BPA enhanced the levels of LC3A/B, bax/bcl2 ratio, cleaved caspase-3, and vascular cell adhesion molecule-1. Green tea extract, EGCG, and vitamin E co-treatment with BPA diminished the toxic effects of BPA. These findings provide evidence that green tea extract and EGCG possess beneficial effects in preventing BPA-induced vascular toxicity through increasing the antioxidant activities and the regulation of signaling pathways." @default.
• W3084046500 created "2020-09-14" @default.
• W3084046500 creator A5001279837 @default.
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• W3084046500 creator A5044889423 @default.
• W3084046500 date "2020-09-07" @default.
• W3084046500 modified "2023-09-26" @default.
• W3084046500 title "Evaluation of green tea extract and epigallocatechin gallate effects on bisphenol A‐induced vascular toxicity in isolated rat aorta and cytotoxicity in human umbilical vein endothelial cells" @default.
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• W3084046500 doi "https://doi.org/10.1002/ptr.6861" @default.
• W3084046500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32893422" @default.
• W3084046500 hasPublicationYear "2020" @default.

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