Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084051922> ?p ?o ?g. }
- W3084051922 endingPage "108218" @default.
- W3084051922 startingPage "108218" @default.
- W3084051922 abstract "This review details the current understanding of the mechanism of action and corneal effects of mitomycin C (MMC) for prophylactic prevention of stromal fibrosis after photorefractive keratectomy (PRK), and includes discussion of available information on dosage and exposure time recommended for MMC during PRK. MMC is an alkylating agent, with DNA-crosslinking activity, that inhibits DNA replication and cellular proliferation. It acts as a pro-drug and requires reduction in the tissue to be converted to an active agent capable of DNA alkylation. Although MMC augments the early keratocyte apoptosis wave in the anterior corneal stroma, its most important effect responsible for inhibition of fibrosis in surface ablation procedures such as PRK is via the inhibition of mitosis of myofibroblast precursor cells during the first few weeks after PRK. MMC use is especially useful when treating eyes with higher levels of myopia (≥approximately 6 D), which have shown higher risk of developing fibrosis (also clinically termed late haze). Studies have supported the use of MMC at a concentration of 0.02%, rather than lower doses (such as 0.01% or 0.002%), for optimal reduction of fibrosis after PRK. Exposure times for 0.02% MMC longer than 40 s may be beneficial for moderate to high myopia (≥6D), but shorter exposures times appear to be equally effective for lower levels of myopia. Although MMC treatment may also be beneficial in preventing fibrosis after PRK treatments for hyperopia and astigmatism, more studies are needed. Thus, despite the clinical use of MMC after PRK for nearly twenty years-with limited evidence of harmful effects in the cornea-many decades of experience will be needed to exclude late long-term effects that could be noted after MMC treatment." @default.
- W3084051922 created "2020-09-14" @default.
- W3084051922 creator A5010475533 @default.
- W3084051922 creator A5039779967 @default.
- W3084051922 date "2020-11-01" @default.
- W3084051922 modified "2023-09-30" @default.
- W3084051922 title "Biological effects of mitomycin C on late corneal haze stromal fibrosis following PRK" @default.
- W3084051922 cites W12638607 @default.
- W3084051922 cites W1527731928 @default.
- W3084051922 cites W1537094952 @default.
- W3084051922 cites W1605455787 @default.
- W3084051922 cites W168003325 @default.
- W3084051922 cites W1885351946 @default.
- W3084051922 cites W192533254 @default.
- W3084051922 cites W1949741226 @default.
- W3084051922 cites W1964192210 @default.
- W3084051922 cites W1964306615 @default.
- W3084051922 cites W1964875721 @default.
- W3084051922 cites W1965977008 @default.
- W3084051922 cites W1966684193 @default.
- W3084051922 cites W197120085 @default.
- W3084051922 cites W1972637291 @default.
- W3084051922 cites W1973540550 @default.
- W3084051922 cites W1974986708 @default.
- W3084051922 cites W1981469704 @default.
- W3084051922 cites W1981504985 @default.
- W3084051922 cites W1982619440 @default.
- W3084051922 cites W1985242808 @default.
- W3084051922 cites W1988512344 @default.
- W3084051922 cites W1989050853 @default.
- W3084051922 cites W1994755459 @default.
- W3084051922 cites W1995709344 @default.
- W3084051922 cites W2000939333 @default.
- W3084051922 cites W2001025562 @default.
- W3084051922 cites W2002124945 @default.
- W3084051922 cites W2007328360 @default.
- W3084051922 cites W2010330226 @default.
- W3084051922 cites W2010806716 @default.
- W3084051922 cites W2011585564 @default.
- W3084051922 cites W2014340674 @default.
- W3084051922 cites W2014395131 @default.
- W3084051922 cites W2019098558 @default.
- W3084051922 cites W2021693016 @default.
- W3084051922 cites W2022653414 @default.
- W3084051922 cites W2024607328 @default.
- W3084051922 cites W2026381584 @default.
- W3084051922 cites W2035206828 @default.
- W3084051922 cites W2037250064 @default.
- W3084051922 cites W2042343633 @default.
- W3084051922 cites W2043736834 @default.
- W3084051922 cites W2044446186 @default.
- W3084051922 cites W2048725909 @default.
- W3084051922 cites W2052321296 @default.
- W3084051922 cites W2052485885 @default.
- W3084051922 cites W2053117759 @default.
- W3084051922 cites W2054420930 @default.
- W3084051922 cites W2058117121 @default.
- W3084051922 cites W2058508228 @default.
- W3084051922 cites W2059822562 @default.
- W3084051922 cites W2061643429 @default.
- W3084051922 cites W2064358993 @default.
- W3084051922 cites W2067417992 @default.
- W3084051922 cites W2068689248 @default.
- W3084051922 cites W2068947136 @default.
- W3084051922 cites W2072524138 @default.
- W3084051922 cites W2073093267 @default.
- W3084051922 cites W2076480250 @default.
- W3084051922 cites W2077387862 @default.
- W3084051922 cites W2082890878 @default.
- W3084051922 cites W2083015939 @default.
- W3084051922 cites W2086432076 @default.
- W3084051922 cites W2086541575 @default.
- W3084051922 cites W2088808945 @default.
- W3084051922 cites W2090662748 @default.
- W3084051922 cites W2091428132 @default.
- W3084051922 cites W2109582812 @default.
- W3084051922 cites W2112980158 @default.
- W3084051922 cites W2118942456 @default.
- W3084051922 cites W2120729063 @default.
- W3084051922 cites W2128018069 @default.
- W3084051922 cites W2128245487 @default.
- W3084051922 cites W2131491515 @default.
- W3084051922 cites W2135630723 @default.
- W3084051922 cites W2138916951 @default.
- W3084051922 cites W2149640975 @default.
- W3084051922 cites W2150974892 @default.
- W3084051922 cites W2159002826 @default.
- W3084051922 cites W2160457820 @default.
- W3084051922 cites W2164117279 @default.
- W3084051922 cites W2219429396 @default.
- W3084051922 cites W2257714393 @default.
- W3084051922 cites W2319404389 @default.
- W3084051922 cites W2321852657 @default.
- W3084051922 cites W2334698961 @default.
- W3084051922 cites W2382728254 @default.
- W3084051922 cites W2397043795 @default.
- W3084051922 cites W2398444993 @default.
- W3084051922 cites W2418456256 @default.