Matches in SemOpenAlex for { <https://semopenalex.org/work/W308408054> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W308408054 endingPage "311" @default.
- W308408054 startingPage "306" @default.
- W308408054 abstract "The population frequency of germline mutations predisposing to hereditary nonpolyposis colorectal cancer (HNPCC) is unknown. Several epidemiological studies have addressed the problem, and estimates on the proportion of the total colorectal cancer burden accounted for by HNPCC have varied between 0.5% and 13%. In the absence of any clinical diagnostic hallmarks, the definition of HNPCC is based on family history. The problem in defining the syndrome is reflected in the wide range of frequency estimates. The molecular background of HNPCC has recently been clarified. Defects in a total of five different mismatch repair genes have been associated with the syndrome. Tumors associated with HNPCC display microsatellite instability (or replication error, RER). RER analysis followed by germline mutation analysis in the mismatch repair genes allows molecular diagnosis in a proportion of HNPCC patients. These diagnostic methods are likely to contribute to our understanding of the epidemiology of HNPCC. In Finland, the centralized health care system, population history, and recent advances in molecular genetic research have together created tools to evaluate the molecular epidemiology of HNPCC in the country.KeywordsHereditary Nonpolyposis Colorectal CancerMismatch Repair GeneHNPCC PatientMLH1 MutationFamilial Colorectal CancerThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W308408054 created "2016-06-24" @default.
- W308408054 creator A5043116623 @default.
- W308408054 date "1998-01-01" @default.
- W308408054 modified "2023-09-26" @default.
- W308408054 title "Molecular Epidemiology of Hereditary Nonpolyposis Colorectal Cancer in Finland" @default.
- W308408054 cites W1973796414 @default.
- W308408054 cites W1977284533 @default.
- W308408054 cites W1981112371 @default.
- W308408054 cites W1986937402 @default.
- W308408054 cites W1995819860 @default.
- W308408054 cites W2017312352 @default.
- W308408054 cites W2021244375 @default.
- W308408054 cites W2027127660 @default.
- W308408054 cites W2044643325 @default.
- W308408054 cites W2052165838 @default.
- W308408054 cites W2053827853 @default.
- W308408054 cites W2058370198 @default.
- W308408054 cites W2067028787 @default.
- W308408054 cites W2067940389 @default.
- W308408054 cites W2073917725 @default.
- W308408054 cites W2080952568 @default.
- W308408054 cites W2098311021 @default.
- W308408054 cites W2124416807 @default.
- W308408054 cites W2124896165 @default.
- W308408054 cites W2139964075 @default.
- W308408054 doi "https://doi.org/10.1007/978-3-642-46870-4_22" @default.
- W308408054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10027011" @default.
- W308408054 hasPublicationYear "1998" @default.
- W308408054 type Work @default.
- W308408054 sameAs 308408054 @default.
- W308408054 citedByCount "15" @default.
- W308408054 crossrefType "book-chapter" @default.
- W308408054 hasAuthorship W308408054A5043116623 @default.
- W308408054 hasConcept C104317684 @default.
- W308408054 hasConcept C107130276 @default.
- W308408054 hasConcept C121608353 @default.
- W308408054 hasConcept C126322002 @default.
- W308408054 hasConcept C13514818 @default.
- W308408054 hasConcept C135763542 @default.
- W308408054 hasConcept C143998085 @default.
- W308408054 hasConcept C177860879 @default.
- W308408054 hasConcept C180754005 @default.
- W308408054 hasConcept C2776559941 @default.
- W308408054 hasConcept C2779767149 @default.
- W308408054 hasConcept C2908647359 @default.
- W308408054 hasConcept C501734568 @default.
- W308408054 hasConcept C526805850 @default.
- W308408054 hasConcept C54355233 @default.
- W308408054 hasConcept C60748783 @default.
- W308408054 hasConcept C61320498 @default.
- W308408054 hasConcept C71924100 @default.
- W308408054 hasConcept C86803240 @default.
- W308408054 hasConcept C97669555 @default.
- W308408054 hasConcept C99454951 @default.
- W308408054 hasConceptScore W308408054C104317684 @default.
- W308408054 hasConceptScore W308408054C107130276 @default.
- W308408054 hasConceptScore W308408054C121608353 @default.
- W308408054 hasConceptScore W308408054C126322002 @default.
- W308408054 hasConceptScore W308408054C13514818 @default.
- W308408054 hasConceptScore W308408054C135763542 @default.
- W308408054 hasConceptScore W308408054C143998085 @default.
- W308408054 hasConceptScore W308408054C177860879 @default.
- W308408054 hasConceptScore W308408054C180754005 @default.
- W308408054 hasConceptScore W308408054C2776559941 @default.
- W308408054 hasConceptScore W308408054C2779767149 @default.
- W308408054 hasConceptScore W308408054C2908647359 @default.
- W308408054 hasConceptScore W308408054C501734568 @default.
- W308408054 hasConceptScore W308408054C526805850 @default.
- W308408054 hasConceptScore W308408054C54355233 @default.
- W308408054 hasConceptScore W308408054C60748783 @default.
- W308408054 hasConceptScore W308408054C61320498 @default.
- W308408054 hasConceptScore W308408054C71924100 @default.
- W308408054 hasConceptScore W308408054C86803240 @default.
- W308408054 hasConceptScore W308408054C97669555 @default.
- W308408054 hasConceptScore W308408054C99454951 @default.
- W308408054 hasLocation W3084080541 @default.
- W308408054 hasLocation W3084080542 @default.
- W308408054 hasOpenAccess W308408054 @default.
- W308408054 hasPrimaryLocation W3084080541 @default.
- W308408054 hasRelatedWork W1982046407 @default.
- W308408054 hasRelatedWork W1982950345 @default.
- W308408054 hasRelatedWork W2015035823 @default.
- W308408054 hasRelatedWork W2018222321 @default.
- W308408054 hasRelatedWork W2158164398 @default.
- W308408054 hasRelatedWork W2369795258 @default.
- W308408054 hasRelatedWork W2530015585 @default.
- W308408054 hasRelatedWork W3030980312 @default.
- W308408054 hasRelatedWork W308408054 @default.
- W308408054 hasRelatedWork W3128164901 @default.
- W308408054 isParatext "false" @default.
- W308408054 isRetracted "false" @default.
- W308408054 magId "308408054" @default.
- W308408054 workType "book-chapter" @default.