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• W3084156728 endingPage "e1008767" @default.
• W3084156728 startingPage "e1008767" @default.
• W3084156728 abstract "Many viruses target signal transducer and activator of transcription (STAT) 1 to antagonise antiviral interferon signalling, but targeting of STAT3, a pleiotropic molecule that mediates signalling by diverse cytokines, is poorly understood. Here, using lyssavirus infection, quantitative live cell imaging, innate immune signalling and protein interaction assays, and complementation/depletion of STAT expression, we show that STAT3 antagonism is conserved among P-proteins of diverse pathogenic lyssaviruses and correlates with pathogenesis. Importantly, P-protein targeting of STAT3 involves a highly selective mechanism whereby P-protein antagonises cytokine-activated STAT3-STAT1 heterodimers, but not STAT3 homodimers. RT-qPCR and reporter gene assays indicate that this results in specific modulation of interleukin-6-dependent pathways, effecting differential antagonism of target genes. These data provide novel insights into mechanisms by which viruses can modulate cellular function to support infection through discriminatory targeting of immune signalling complexes. The findings also highlight the potential application of selective interferon-antagonists as tools to delineate signalling by particular STAT complexes, significant not only to pathogen-host interactions but also cell physiology, development and cancer." @default.
• W3084156728 created "2020-09-14" @default.
• W3084156728 creator A5005605883 @default.
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• W3084156728 date "2020-09-09" @default.
• W3084156728 modified "2023-10-17" @default.
• W3084156728 title "Lyssavirus P-protein selectively targets STAT3-STAT1 heterodimers to modulate cytokine signalling" @default.
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• W3084156728 cites W1673995928 @default.
• W3084156728 cites W1964316194 @default.
• W3084156728 cites W1966897067 @default.
• W3084156728 cites W1968936285 @default.
• W3084156728 cites W1972709515 @default.
• W3084156728 cites W1975062532 @default.
• W3084156728 cites W1978525119 @default.
• W3084156728 cites W1978720404 @default.
• W3084156728 cites W1983800149 @default.
• W3084156728 cites W1983989619 @default.
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• W3084156728 cites W1991952172 @default.
• W3084156728 cites W2001678839 @default.
• W3084156728 cites W2003402857 @default.
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• W3084156728 cites W2034974668 @default.
• W3084156728 cites W2040409641 @default.
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• W3084156728 cites W2062108803 @default.
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• W3084156728 cites W2071886635 @default.
• W3084156728 cites W2073034493 @default.
• W3084156728 cites W2075490622 @default.
• W3084156728 cites W2078844752 @default.
• W3084156728 cites W2085173477 @default.
• W3084156728 cites W2086655271 @default.
• W3084156728 cites W2086840459 @default.
• W3084156728 cites W2094425321 @default.
• W3084156728 cites W2095598443 @default.
• W3084156728 cites W2101063537 @default.
• W3084156728 cites W2102884496 @default.
• W3084156728 cites W2105479844 @default.
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• W3084156728 cites W2111962787 @default.
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• W3084156728 cites W2129274801 @default.
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• W3084156728 cites W2148138332 @default.
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• W3084156728 cites W2157556858 @default.
• W3084156728 cites W2159370470 @default.
• W3084156728 cites W2160443591 @default.
• W3084156728 cites W2165849880 @default.
• W3084156728 cites W2167495106 @default.
• W3084156728 cites W2170090299 @default.
• W3084156728 cites W2313930706 @default.
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• W3084156728 cites W2885687633 @default.
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• W3084156728 doi "https://doi.org/10.1371/journal.ppat.1008767" @default.
• W3084156728 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7480851" @default.
• W3084156728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32903273" @default.
• W3084156728 hasPublicationYear "2020" @default.
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