Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084204588> ?p ?o ?g. }
- W3084204588 abstract "Abstract Cerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although several studies have demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), its mechanisms in cerebellar ataxia remain largely unknown. Here, we investigated the neuroprotective effects of H.E. treatment in an animal model of 3-acetylpyridine (3-AP)-induced cerebellar ataxia. Animals administered 3-AP injection exhibited remarkable impairments in motor coordination and balance. There were no significant effects of 25 mg/kg H.E. on the 3-AP treatment group compared to the 3-AP saline group. Interestingly, there was also no significant difference in the 3-AP treatment group compared to the non-3-AP control, indicating a potential rescue of motor deficits. Our results revealed that 25 mg/kg H.E. normalised the neuroplasticity-related gene expression to the level of non-3-AP control. These findings were further supported by increased protein expressions of pERK1/2-pCREB-PSD95 as well as neuroprotective effects on cerebellar Purkinje cells in the 3-AP treatment group compared to the 3-AP saline group. In conclusion, our findings suggest that H.E. potentially rescued behavioural motor deficits through the neuroprotective mechanisms of ERK-CREB-PSD95 in an animal model of 3-AP-induced cerebellar ataxia." @default.
- W3084204588 created "2020-09-14" @default.
- W3084204588 creator A5021163228 @default.
- W3084204588 creator A5021877663 @default.
- W3084204588 creator A5029439038 @default.
- W3084204588 creator A5037104735 @default.
- W3084204588 creator A5048438032 @default.
- W3084204588 creator A5063519561 @default.
- W3084204588 creator A5077093072 @default.
- W3084204588 creator A5082370949 @default.
- W3084204588 creator A5090521979 @default.
- W3084204588 date "2020-09-10" @default.
- W3084204588 modified "2023-10-09" @default.
- W3084204588 title "Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia" @default.
- W3084204588 cites W1857922832 @default.
- W3084204588 cites W1894263044 @default.
- W3084204588 cites W1924082254 @default.
- W3084204588 cites W1964901370 @default.
- W3084204588 cites W1966449086 @default.
- W3084204588 cites W1967782531 @default.
- W3084204588 cites W1970512854 @default.
- W3084204588 cites W1976721630 @default.
- W3084204588 cites W1981720666 @default.
- W3084204588 cites W1983520660 @default.
- W3084204588 cites W1987686962 @default.
- W3084204588 cites W1989036685 @default.
- W3084204588 cites W1989684700 @default.
- W3084204588 cites W1994063457 @default.
- W3084204588 cites W1994329231 @default.
- W3084204588 cites W1996717216 @default.
- W3084204588 cites W2004303128 @default.
- W3084204588 cites W2005000574 @default.
- W3084204588 cites W2007784092 @default.
- W3084204588 cites W2008651002 @default.
- W3084204588 cites W2010114986 @default.
- W3084204588 cites W2011580597 @default.
- W3084204588 cites W2013167404 @default.
- W3084204588 cites W2014436770 @default.
- W3084204588 cites W2019819938 @default.
- W3084204588 cites W2021939469 @default.
- W3084204588 cites W2024862570 @default.
- W3084204588 cites W2026993626 @default.
- W3084204588 cites W2036812869 @default.
- W3084204588 cites W2036914347 @default.
- W3084204588 cites W2039911198 @default.
- W3084204588 cites W2041446008 @default.
- W3084204588 cites W2046647858 @default.
- W3084204588 cites W2047260938 @default.
- W3084204588 cites W2050016002 @default.
- W3084204588 cites W2055380229 @default.
- W3084204588 cites W2056026993 @default.
- W3084204588 cites W2065528657 @default.
- W3084204588 cites W2071222048 @default.
- W3084204588 cites W2080286673 @default.
- W3084204588 cites W2087557683 @default.
- W3084204588 cites W2091293321 @default.
- W3084204588 cites W2091392236 @default.
- W3084204588 cites W2092544119 @default.
- W3084204588 cites W2094776415 @default.
- W3084204588 cites W2102450682 @default.
- W3084204588 cites W2107277218 @default.
- W3084204588 cites W2113734421 @default.
- W3084204588 cites W2116460180 @default.
- W3084204588 cites W2118528216 @default.
- W3084204588 cites W2121090415 @default.
- W3084204588 cites W2129974396 @default.
- W3084204588 cites W2131090783 @default.
- W3084204588 cites W2132715852 @default.
- W3084204588 cites W2151770661 @default.
- W3084204588 cites W2158628437 @default.
- W3084204588 cites W2163931885 @default.
- W3084204588 cites W2168056522 @default.
- W3084204588 cites W2287284764 @default.
- W3084204588 cites W2311740292 @default.
- W3084204588 cites W2325707043 @default.
- W3084204588 cites W2413561614 @default.
- W3084204588 cites W2417175566 @default.
- W3084204588 cites W2528296688 @default.
- W3084204588 cites W2548185771 @default.
- W3084204588 cites W2549873609 @default.
- W3084204588 cites W2566001948 @default.
- W3084204588 cites W2583006166 @default.
- W3084204588 cites W2612702283 @default.
- W3084204588 cites W2766045016 @default.
- W3084204588 cites W2767063417 @default.
- W3084204588 cites W2767216402 @default.
- W3084204588 cites W2793831335 @default.
- W3084204588 cites W2804153279 @default.
- W3084204588 cites W2808766021 @default.
- W3084204588 cites W2898005291 @default.
- W3084204588 cites W2902129765 @default.
- W3084204588 cites W2924201215 @default.
- W3084204588 cites W2937276428 @default.
- W3084204588 cites W2979096324 @default.
- W3084204588 cites W2980977796 @default.
- W3084204588 cites W2997533635 @default.
- W3084204588 cites W3004542412 @default.
- W3084204588 cites W3011545626 @default.
- W3084204588 cites W3141299624 @default.
- W3084204588 cites W4211103360 @default.