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- W3084235443 abstract "Glioblastoma and other high-grade gliomas (HGGs) are the most common and deadly primary brain tumors. Due to recent advances in immunotherapy and improved clinical outcomes in other disease sites, the study of immunotherapy in HGG has increased significantly. Herein, we summarize and evaluate existing evidence and ongoing clinical trials investigating the use of immunotherapy in the treatment of HGG, including therapeutic vaccination, immune checkpoint inhibition, adoptive lymphocyte transfer, and combinatorial approaches utilizing radiation and multiple modalities of immunotherapy. Special attention is given to the mechanisms by which radiation may improve immunogenicity in HGG, why this motivates the study of radiation in combination with immunotherapy, and how to determine optimal dosing and scheduling of radiation. Though larger randomized controlled trials have not consistently shown improvements in clinical outcomes, this area of research is still in its early stages and a number of important lessons can be taken away from the studies that have been completed to date. Many studies found a subset of patients who experienced durable responses, and analysis of their immune cells and tumor cells can be used to identify biomarkers that predict therapeutic response, as well as additional glioma-specific targets that can enhance therapeutic efficacy in a challenging tumor type." @default.
- W3084235443 created "2020-09-14" @default.
- W3084235443 creator A5009428042 @default.
- W3084235443 creator A5055031500 @default.
- W3084235443 creator A5069715843 @default.
- W3084235443 creator A5090748784 @default.
- W3084235443 date "2021-05-01" @default.
- W3084235443 modified "2023-10-14" @default.
- W3084235443 title "Immunotherapy and radiation for high-grade glioma: a narrative review" @default.
- W3084235443 cites W1513125948 @default.
- W3084235443 cites W1515599953 @default.
- W3084235443 cites W1533046157 @default.
- W3084235443 cites W1555650656 @default.
- W3084235443 cites W1590169267 @default.
- W3084235443 cites W1828443506 @default.
- W3084235443 cites W1965273547 @default.
- W3084235443 cites W1966988865 @default.
- W3084235443 cites W1968964239 @default.
- W3084235443 cites W1970174108 @default.
- W3084235443 cites W1989566870 @default.
- W3084235443 cites W1990602451 @default.
- W3084235443 cites W1994826332 @default.
- W3084235443 cites W2003726414 @default.
- W3084235443 cites W2005438334 @default.
- W3084235443 cites W2008259119 @default.
- W3084235443 cites W2010956784 @default.
- W3084235443 cites W2013020286 @default.
- W3084235443 cites W2017389700 @default.
- W3084235443 cites W2020604769 @default.
- W3084235443 cites W2022132178 @default.
- W3084235443 cites W2024980830 @default.
- W3084235443 cites W2025421597 @default.
- W3084235443 cites W2026830644 @default.
- W3084235443 cites W2026938154 @default.
- W3084235443 cites W2032792022 @default.
- W3084235443 cites W2033118453 @default.
- W3084235443 cites W2036374837 @default.
- W3084235443 cites W2038702089 @default.
- W3084235443 cites W2042444567 @default.
- W3084235443 cites W2043043829 @default.
- W3084235443 cites W2043732412 @default.
- W3084235443 cites W2048950080 @default.
- W3084235443 cites W2049429882 @default.
- W3084235443 cites W2049553585 @default.
- W3084235443 cites W2050302632 @default.
- W3084235443 cites W2053393698 @default.
- W3084235443 cites W2056679169 @default.
- W3084235443 cites W2056924571 @default.
- W3084235443 cites W2060231435 @default.
- W3084235443 cites W2063622451 @default.
- W3084235443 cites W2072140854 @default.
- W3084235443 cites W2077476931 @default.
- W3084235443 cites W2078461037 @default.
- W3084235443 cites W2079018735 @default.
- W3084235443 cites W2082515801 @default.
- W3084235443 cites W2083054031 @default.
- W3084235443 cites W2085991037 @default.
- W3084235443 cites W2093424661 @default.
- W3084235443 cites W2093887577 @default.
- W3084235443 cites W2094366129 @default.
- W3084235443 cites W2094804545 @default.
- W3084235443 cites W2096287682 @default.
- W3084235443 cites W2096555449 @default.
- W3084235443 cites W2097995306 @default.
- W3084235443 cites W2100004531 @default.
- W3084235443 cites W2103212167 @default.
- W3084235443 cites W2104885590 @default.
- W3084235443 cites W2107098070 @default.
- W3084235443 cites W2108789863 @default.
- W3084235443 cites W2110632746 @default.
- W3084235443 cites W2111837231 @default.
- W3084235443 cites W2112680373 @default.
- W3084235443 cites W2120077013 @default.
- W3084235443 cites W2120963683 @default.
- W3084235443 cites W2121080034 @default.
- W3084235443 cites W2123808042 @default.
- W3084235443 cites W2124427232 @default.
- W3084235443 cites W2125616358 @default.
- W3084235443 cites W2125697254 @default.
- W3084235443 cites W2125966088 @default.
- W3084235443 cites W2126817554 @default.
- W3084235443 cites W2127716652 @default.
- W3084235443 cites W2127733313 @default.
- W3084235443 cites W2128035403 @default.
- W3084235443 cites W2129387595 @default.
- W3084235443 cites W2132697290 @default.
- W3084235443 cites W2137405984 @default.
- W3084235443 cites W2137425777 @default.
- W3084235443 cites W2137605317 @default.
- W3084235443 cites W2137930630 @default.
- W3084235443 cites W2140231263 @default.
- W3084235443 cites W2140738072 @default.
- W3084235443 cites W2141099036 @default.
- W3084235443 cites W2145625732 @default.
- W3084235443 cites W2146881779 @default.
- W3084235443 cites W2149768128 @default.
- W3084235443 cites W2150065276 @default.
- W3084235443 cites W2150293352 @default.