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- W3084295570 endingPage "6578" @default.
- W3084295570 startingPage "6578" @default.
- W3084295570 abstract "Epitranscriptomics analyze the biochemical modifications borne by RNA and their downstream influence. From this point of view, epitranscriptomics represent a new layer for the control of genetic information and can affect a variety of molecular processes including the cell cycle and the differentiation. In physiological conditions, hematopoiesis is a tightly regulated process that produces differentiated blood cells starting from hematopoietic stem cells. Alteration of this process can occur at different levels in the pathway that leads from the genetic information to the phenotypic manifestation producing malignant hematopoiesis. This review focuses on the role of epitranscriptomic events that are known to be implicated in normal and malignant hematopoiesis, opening a new pathophysiological and therapeutic scenario. Moreover, an evolutionary vision of this mechanism will be provided." @default.
- W3084295570 created "2020-09-14" @default.
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- W3084295570 date "2020-09-09" @default.
- W3084295570 modified "2023-09-26" @default.
- W3084295570 title "Epitranscriptomics in Normal and Malignant Hematopoiesis" @default.
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- W3084295570 doi "https://doi.org/10.3390/ijms21186578" @default.
- W3084295570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7555315" @default.
- W3084295570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32916783" @default.
- W3084295570 hasPublicationYear "2020" @default.
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