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- W3084307963 abstract "Background: Orexin is a neuropeptide which can influence a wide range of physiological functions including blood pressure, sympathetic nervous system activity and arousal. Orexinergic signalling is suggested to contribute to the neurogenic hypertension in BPH/2J mice, based on the hypotensive response to the dual orexin receptor (OxR) antagonist, Almorexant, which was not observed in normotensive BPN/3J controls. Orexin is also known to influence the cardiovascular response to certain stressors. Thus, it is possible that orexin may also contribute to the exaggerated pressor response to stress that is reported in BPH/2J mice. Objective: To determine the contribution of orexin to the hypertension and exaggerated stress reactivity in BPH/2J wild type mice by comparing with BPH/2J Orexin homozygous knock out (BPH OxKO) mice. Methods: BPH OxKO (n=9) and BPH wild type (BPH WT) mice (n=6) were implanted with radiotelemetry probes to measure blood pressure (BP), heart rate (HR) and locomotor activity across the 24hr period and in response to restraint and dirty cage swap stressors. The BP responses to ganglion blocker pentolinium (5mg/kg, i.p.), was also measured. Results: There was no difference in average mean arterial pressure (MAP) over the 24hr period in BPH OxKO mice (131±1 vs 133±1mmHg, P =0.351), but there was a modest elevation in systolic AP (+4.5mmHg) exclusively during light period in BPH OxKO compared with BPH WT mice (145±2 vs 141±2mmHg, P <0.032). HR was comparable between strains ( P =0.160) and locomotor activity tended to be lower in BPH OxKO compared with BPH WT mice during the dark period (1.1±0.2 vs 1.7±0.3 units respectively, P =0.051). The pressor response to dirty cage swap stress was lower in BPH OxKO compared with BPH WT mice (22±1 vs 28±1mmHg respectively, P <0.001), as was the response to restraint stress (36±1 vs 40±2mmHg respectively, P <0.05). The depressor response to ganglion blockade was comparable between strains ( P =0.255). Conclusion: The present findings suggest that whilst orexin does not contribute to sympathetically mediated hypertension, it may play a role in the exaggerated cardiovascular response to stress and hyperactivity in BPH/2J mice." @default.
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- W3084307963 date "2020-09-01" @default.
- W3084307963 modified "2023-09-27" @default.
- W3084307963 title "Abstract 18: Orexin Knockout BPH/2J Hypertensive Mice Still Have Elevated Basal Blood Pressure But Lower Stress Reactivity" @default.
- W3084307963 doi "https://doi.org/10.1161/hyp.76.suppl_1.18" @default.
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