Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084317835> ?p ?o ?g. }
- W3084317835 endingPage "86" @default.
- W3084317835 startingPage "66" @default.
- W3084317835 abstract "Pulmonary delivery has gained increased interests over the past few decades. For respiratory conditions, targeted drug delivery directly to the site of action can achieve a high local concentration for efficacy with reduced systemic exposure and adverse effects. For systemic conditions, the unique physiology of the lung evolutionarily designed for rapid gaseous exchange presents an entry route for systemic drug delivery. Although the development of inhaled formulations has come a long way over the last few decades, many aspects of it remain to be elucidated. In particular, a reliable and well-understood method for in vitro-in vivo correlations remains to be established. With the rapid and ongoing advancement of technology, there is much potential to better utilise computational methods including different types of modelling and simulation approaches to support inhaled formulation development. This review intends to provide an introduction on some fundamental concepts in pulmonary drug delivery and inhaled formulation development followed by discussions on some challenges and opportunities in the translation of inhaled pharmaceuticals from preclinical studies to clinical development. The review concludes with some recent advancements in modelling and simulation approaches that could play an increasingly important role in modern formulation development of inhaled pharmaceuticals." @default.
- W3084317835 created "2020-09-14" @default.
- W3084317835 creator A5068174912 @default.
- W3084317835 creator A5071908671 @default.
- W3084317835 date "2021-01-01" @default.
- W3084317835 modified "2023-10-17" @default.
- W3084317835 title "Contemporary Formulation Development for Inhaled Pharmaceuticals" @default.
- W3084317835 cites W1073059545 @default.
- W3084317835 cites W133577376 @default.
- W3084317835 cites W1498305210 @default.
- W3084317835 cites W1502147118 @default.
- W3084317835 cites W152943885 @default.
- W3084317835 cites W1531843671 @default.
- W3084317835 cites W1542410198 @default.
- W3084317835 cites W1546515148 @default.
- W3084317835 cites W1575908580 @default.
- W3084317835 cites W1688184607 @default.
- W3084317835 cites W1751557895 @default.
- W3084317835 cites W1777095277 @default.
- W3084317835 cites W1802983559 @default.
- W3084317835 cites W1848087071 @default.
- W3084317835 cites W1897626150 @default.
- W3084317835 cites W1915635001 @default.
- W3084317835 cites W1920101996 @default.
- W3084317835 cites W1926492028 @default.
- W3084317835 cites W1963448699 @default.
- W3084317835 cites W1963724548 @default.
- W3084317835 cites W1964152658 @default.
- W3084317835 cites W1965985576 @default.
- W3084317835 cites W1966415141 @default.
- W3084317835 cites W1966821331 @default.
- W3084317835 cites W1969143667 @default.
- W3084317835 cites W1970342848 @default.
- W3084317835 cites W1971019612 @default.
- W3084317835 cites W1973118254 @default.
- W3084317835 cites W1973324320 @default.
- W3084317835 cites W1974671188 @default.
- W3084317835 cites W1975872618 @default.
- W3084317835 cites W1976647842 @default.
- W3084317835 cites W1977959685 @default.
- W3084317835 cites W1979514154 @default.
- W3084317835 cites W1980898338 @default.
- W3084317835 cites W1984230056 @default.
- W3084317835 cites W1984477495 @default.
- W3084317835 cites W1985698260 @default.
- W3084317835 cites W1986421799 @default.
- W3084317835 cites W1987679858 @default.
- W3084317835 cites W1988266296 @default.
- W3084317835 cites W1990025592 @default.
- W3084317835 cites W1990566179 @default.
- W3084317835 cites W1990591637 @default.
- W3084317835 cites W1991310381 @default.
- W3084317835 cites W1993485720 @default.
- W3084317835 cites W1993548548 @default.
- W3084317835 cites W1993838495 @default.
- W3084317835 cites W1994370221 @default.
- W3084317835 cites W1995651579 @default.
- W3084317835 cites W1997164048 @default.
- W3084317835 cites W1997587724 @default.
- W3084317835 cites W1998868963 @default.
- W3084317835 cites W1998944697 @default.
- W3084317835 cites W2001132794 @default.
- W3084317835 cites W2001492346 @default.
- W3084317835 cites W2002562802 @default.
- W3084317835 cites W2003132032 @default.
- W3084317835 cites W2003405209 @default.
- W3084317835 cites W2003950546 @default.
- W3084317835 cites W2004622018 @default.
- W3084317835 cites W2005689848 @default.
- W3084317835 cites W2006759883 @default.
- W3084317835 cites W2013812391 @default.
- W3084317835 cites W2014664741 @default.
- W3084317835 cites W2015391014 @default.
- W3084317835 cites W2017576872 @default.
- W3084317835 cites W2017611918 @default.
- W3084317835 cites W2017730520 @default.
- W3084317835 cites W2018485962 @default.
- W3084317835 cites W2019421631 @default.
- W3084317835 cites W2020430388 @default.
- W3084317835 cites W2020449847 @default.
- W3084317835 cites W2024055277 @default.
- W3084317835 cites W2024180907 @default.
- W3084317835 cites W2025591249 @default.
- W3084317835 cites W2026361452 @default.
- W3084317835 cites W2027079562 @default.
- W3084317835 cites W2027758334 @default.
- W3084317835 cites W2027959934 @default.
- W3084317835 cites W2028210174 @default.
- W3084317835 cites W2028545540 @default.
- W3084317835 cites W2028928991 @default.
- W3084317835 cites W2030022793 @default.
- W3084317835 cites W2030102438 @default.
- W3084317835 cites W2032004794 @default.
- W3084317835 cites W2034651522 @default.
- W3084317835 cites W2038553101 @default.
- W3084317835 cites W2039916561 @default.
- W3084317835 cites W2040017474 @default.
- W3084317835 cites W2040164695 @default.