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- W3084398045 endingPage "6586" @default.
- W3084398045 startingPage "6586" @default.
- W3084398045 abstract "Gastric cancer is the end result of a complex interplay between host genetics, environmental factors, and microbial factors. The link between gut microbiome and gastric cancer has been attributed to persistent activation of the host’s immune system by gut microbiota. The end result of this dysregulated interaction between host epithelium and microbes is a state of chronic inflammation. Gut bacteria can promote anti-tumor immune responses through several mechanisms. These include triggering T-cell responses to bacterial antigens that can cross-react with tumor antigens or cause tumor-specific antigen recognition; engagement of pattern recognition receptors that mediate pro-immune or anti-inflammatory effects or via small metabolites that mediate systemic effects on the host. Here we review the role of the gut microbiome including H. pylori and non-H. pylori gastric bacteria, the immune response, and immunotherapy using checkpoint inhibitors. We also review the evidence for cross talk between the gut microbiome and immune response in gastric cancer." @default.
- W3084398045 created "2020-09-14" @default.
- W3084398045 creator A5053685449 @default.
- W3084398045 creator A5057321351 @default.
- W3084398045 creator A5064576748 @default.
- W3084398045 creator A5087290908 @default.
- W3084398045 creator A5088444923 @default.
- W3084398045 date "2020-09-09" @default.
- W3084398045 modified "2023-10-01" @default.
- W3084398045 title "The Crosstalk between Microbiome and Immune Response in Gastric Cancer" @default.
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