Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084415917> ?p ?o ?g. }
- W3084415917 endingPage "14520" @default.
- W3084415917 startingPage "14507" @default.
- W3084415917 abstract "Fibrosis is a pathological feature of chronic kidney disease and its progression correlates with declining renal function. Kidney fibrosis is driven by multiple profibrotic factors. This project examined the regulatory function of WNT1-inducible-signaling pathway protein 1 (WISP1) in the development of kidney fibrosis. Induction of WISP1 by transforming growth factor beta 1 (TGF-β1), and the role of WISP1 in TGF-β1/Smad signaling and fibrotic responses, was examined in multiple kidney cells. Kidney expression of WISP1 was examined in mouse models of unilateral ureter obstruction (UUO) and streptozotocin-induced diabetic nephropathy. WISP1 antibody was administered to UUO mice during the induction of kidney injury and the impact on kidney fibrosis was examined. WISP1 expression was upregulated in both mouse models. TGF-β1-induced expression of WISP1 and profibrotic genes in cultured kidney cells via TGF-βR1. Recombinant WISP1-induced expression of TGF-βR1 in kidney cells. Suppression of WISP1 by shRNA or neutralizing antibody reduced TGF-β1-mediated activation of Smad3, fibrotic gene expression, and fibroblast proliferation. Treatment with WISP1 antibody inhibited the development of kidney fibrosis in UUO mice. WISP1 mediates the profibrotic effects of TGF-β1 in kidney cells and in kidney disease. Pharmacological blockade of WISP1 exhibits potential as a novel therapy for inhibiting kidney fibrosis." @default.
- W3084415917 created "2020-09-14" @default.
- W3084415917 creator A5005175311 @default.
- W3084415917 creator A5026053684 @default.
- W3084415917 creator A5028159410 @default.
- W3084415917 creator A5049727416 @default.
- W3084415917 creator A5056168495 @default.
- W3084415917 creator A5079548437 @default.
- W3084415917 creator A5089701670 @default.
- W3084415917 creator A5091017114 @default.
- W3084415917 creator A5091565448 @default.
- W3084415917 date "2020-09-07" @default.
- W3084415917 modified "2023-10-16" @default.
- W3084415917 title "WNT1‐inducible‐signaling pathway protein 1 regulates the development of kidney fibrosis through the TGF‐β1 pathway" @default.
- W3084415917 cites W1037510925 @default.
- W3084415917 cites W1910709759 @default.
- W3084415917 cites W1971010914 @default.
- W3084415917 cites W1980369799 @default.
- W3084415917 cites W2018137555 @default.
- W3084415917 cites W2033753222 @default.
- W3084415917 cites W2045675499 @default.
- W3084415917 cites W2055559862 @default.
- W3084415917 cites W2060290432 @default.
- W3084415917 cites W2064606484 @default.
- W3084415917 cites W2077755631 @default.
- W3084415917 cites W2086419185 @default.
- W3084415917 cites W2094404475 @default.
- W3084415917 cites W2101492172 @default.
- W3084415917 cites W2101772851 @default.
- W3084415917 cites W2102298863 @default.
- W3084415917 cites W2103813608 @default.
- W3084415917 cites W2107187767 @default.
- W3084415917 cites W2109974825 @default.
- W3084415917 cites W2123182868 @default.
- W3084415917 cites W2129298815 @default.
- W3084415917 cites W2129536482 @default.
- W3084415917 cites W2136674852 @default.
- W3084415917 cites W2143647993 @default.
- W3084415917 cites W2149830185 @default.
- W3084415917 cites W2169453638 @default.
- W3084415917 cites W2338606193 @default.
- W3084415917 cites W2342679639 @default.
- W3084415917 cites W2347076418 @default.
- W3084415917 cites W2395692822 @default.
- W3084415917 cites W2401390149 @default.
- W3084415917 cites W2748818287 @default.
- W3084415917 cites W2788021881 @default.
- W3084415917 cites W2800799277 @default.
- W3084415917 cites W4321429547 @default.
- W3084415917 doi "https://doi.org/10.1096/fj.202000953r" @default.
- W3084415917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32896021" @default.
- W3084415917 hasPublicationYear "2020" @default.
- W3084415917 type Work @default.
- W3084415917 sameAs 3084415917 @default.
- W3084415917 citedByCount "8" @default.
- W3084415917 countsByYear W30844159172021 @default.
- W3084415917 countsByYear W30844159172022 @default.
- W3084415917 countsByYear W30844159172023 @default.
- W3084415917 crossrefType "journal-article" @default.
- W3084415917 hasAuthorship W3084415917A5005175311 @default.
- W3084415917 hasAuthorship W3084415917A5026053684 @default.
- W3084415917 hasAuthorship W3084415917A5028159410 @default.
- W3084415917 hasAuthorship W3084415917A5049727416 @default.
- W3084415917 hasAuthorship W3084415917A5056168495 @default.
- W3084415917 hasAuthorship W3084415917A5079548437 @default.
- W3084415917 hasAuthorship W3084415917A5089701670 @default.
- W3084415917 hasAuthorship W3084415917A5091017114 @default.
- W3084415917 hasAuthorship W3084415917A5091565448 @default.
- W3084415917 hasConcept C118131993 @default.
- W3084415917 hasConcept C126322002 @default.
- W3084415917 hasConcept C185592680 @default.
- W3084415917 hasConcept C2780091579 @default.
- W3084415917 hasConcept C2780559512 @default.
- W3084415917 hasConcept C502942594 @default.
- W3084415917 hasConcept C62478195 @default.
- W3084415917 hasConcept C71924100 @default.
- W3084415917 hasConcept C86803240 @default.
- W3084415917 hasConcept C95444343 @default.
- W3084415917 hasConceptScore W3084415917C118131993 @default.
- W3084415917 hasConceptScore W3084415917C126322002 @default.
- W3084415917 hasConceptScore W3084415917C185592680 @default.
- W3084415917 hasConceptScore W3084415917C2780091579 @default.
- W3084415917 hasConceptScore W3084415917C2780559512 @default.
- W3084415917 hasConceptScore W3084415917C502942594 @default.
- W3084415917 hasConceptScore W3084415917C62478195 @default.
- W3084415917 hasConceptScore W3084415917C71924100 @default.
- W3084415917 hasConceptScore W3084415917C86803240 @default.
- W3084415917 hasConceptScore W3084415917C95444343 @default.
- W3084415917 hasFunder F4320321001 @default.
- W3084415917 hasFunder F4320335787 @default.
- W3084415917 hasIssue "11" @default.
- W3084415917 hasLocation W30844159171 @default.
- W3084415917 hasOpenAccess W3084415917 @default.
- W3084415917 hasPrimaryLocation W30844159171 @default.
- W3084415917 hasRelatedWork W2034292553 @default.
- W3084415917 hasRelatedWork W2053247969 @default.
- W3084415917 hasRelatedWork W2076190284 @default.
- W3084415917 hasRelatedWork W2165304123 @default.