Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084421801> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3084421801 abstract "The present study reports the synthesis of a series N-substituted derivatives of brominated 2-phenitidine. First, the reaction of 2-phenitidine (1) with benzenesulfonyl chloride (2) in aqueous media yielded N-(2-ethoxyphenyl) benzenesulfonamide (3), which was then subjected to bromination with bromine in the presence of glacial acetic acid to give N-(4,5-dibromo-2-ethoxyphenyl) benzenesulfonamide (4). Secondly, the product (4) on further treatment with alkyl/aryl halides (5a-l) in the presence of lithium hydride (LiH) produced twelve new derivatives of N-substituted sulfonamides (6a-l). These were characterized by (1)H-NMR spectrum and screened against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase (LOX) and were found to be valuable inhibitors of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Few of them were also active against LOX." @default.
- W3084421801 created "2020-09-14" @default.
- W3084421801 creator A5008928173 @default.
- W3084421801 creator A5010816845 @default.
- W3084421801 creator A5023749945 @default.
- W3084421801 creator A5046919924 @default.
- W3084421801 creator A5057207341 @default.
- W3084421801 creator A5079877053 @default.
- W3084421801 date "2014-01-01" @default.
- W3084421801 modified "2023-09-23" @default.
- W3084421801 title "Synthesis of brominated 2-phenitidine derivatives as valuable inhibitors of cholinesterases for the treatment of Alzheimer's disease." @default.
- W3084421801 cites W107049459 @default.
- W3084421801 cites W1964307147 @default.
- W3084421801 cites W1971048984 @default.
- W3084421801 cites W1978968275 @default.
- W3084421801 cites W2036226720 @default.
- W3084421801 cites W2041570449 @default.
- W3084421801 cites W2081589854 @default.
- W3084421801 cites W2088887029 @default.
- W3084421801 cites W2093701215 @default.
- W3084421801 cites W2098154447 @default.
- W3084421801 cites W2107627870 @default.
- W3084421801 cites W2112052430 @default.
- W3084421801 cites W2164320858 @default.
- W3084421801 cites W2180674417 @default.
- W3084421801 cites W2321345607 @default.
- W3084421801 cites W2327582174 @default.
- W3084421801 cites W2740975582 @default.
- W3084421801 cites W44123131 @default.
- W3084421801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3985256" @default.
- W3084421801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24734059" @default.
- W3084421801 hasPublicationYear "2014" @default.
- W3084421801 type Work @default.
- W3084421801 sameAs 3084421801 @default.
- W3084421801 citedByCount "3" @default.
- W3084421801 countsByYear W30844218012015 @default.
- W3084421801 countsByYear W30844218012016 @default.
- W3084421801 countsByYear W30844218012018 @default.
- W3084421801 crossrefType "journal-article" @default.
- W3084421801 hasAuthorship W3084421801A5008928173 @default.
- W3084421801 hasAuthorship W3084421801A5010816845 @default.
- W3084421801 hasAuthorship W3084421801A5023749945 @default.
- W3084421801 hasAuthorship W3084421801A5046919924 @default.
- W3084421801 hasAuthorship W3084421801A5057207341 @default.
- W3084421801 hasAuthorship W3084421801A5079877053 @default.
- W3084421801 hasConcept C155647269 @default.
- W3084421801 hasConcept C178790620 @default.
- W3084421801 hasConcept C181199279 @default.
- W3084421801 hasConcept C185592680 @default.
- W3084421801 hasConcept C2776673659 @default.
- W3084421801 hasConcept C2778816929 @default.
- W3084421801 hasConcept C2779059548 @default.
- W3084421801 hasConcept C2779101902 @default.
- W3084421801 hasConcept C2780263894 @default.
- W3084421801 hasConcept C2781076698 @default.
- W3084421801 hasConcept C31896038 @default.
- W3084421801 hasConcept C65973085 @default.
- W3084421801 hasConcept C71924100 @default.
- W3084421801 hasConcept C98274493 @default.
- W3084421801 hasConceptScore W3084421801C155647269 @default.
- W3084421801 hasConceptScore W3084421801C178790620 @default.
- W3084421801 hasConceptScore W3084421801C181199279 @default.
- W3084421801 hasConceptScore W3084421801C185592680 @default.
- W3084421801 hasConceptScore W3084421801C2776673659 @default.
- W3084421801 hasConceptScore W3084421801C2778816929 @default.
- W3084421801 hasConceptScore W3084421801C2779059548 @default.
- W3084421801 hasConceptScore W3084421801C2779101902 @default.
- W3084421801 hasConceptScore W3084421801C2780263894 @default.
- W3084421801 hasConceptScore W3084421801C2781076698 @default.
- W3084421801 hasConceptScore W3084421801C31896038 @default.
- W3084421801 hasConceptScore W3084421801C65973085 @default.
- W3084421801 hasConceptScore W3084421801C71924100 @default.
- W3084421801 hasConceptScore W3084421801C98274493 @default.
- W3084421801 hasLocation W30844218011 @default.
- W3084421801 hasOpenAccess W3084421801 @default.
- W3084421801 hasPrimaryLocation W30844218011 @default.
- W3084421801 isParatext "false" @default.
- W3084421801 isRetracted "false" @default.
- W3084421801 magId "3084421801" @default.
- W3084421801 workType "article" @default.