FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084447710> ?p ?o ?g. }

• W3084447710 abstract "This thesis presents data of analysing T cell responses to synthetic Ras peptides and to natural peptide epitopes derived from minor histocompatibility (mH) antigens. Murine T helper and cytotoxic T lymphocyte (CTL) responses were induced by synthetic peptides corresponding to amino acids 1-23 of the normal or mutant p21Ras proteins containing a glycine to valine mutation at position 12. Specific T helper responses against mutant Ras peptide were observed in C3H/He, B10.BR but not C57BL/10 mice. These responses were mediated by CD4+ cells and restricted by MHC class II molecules. Moreover, mutant Ras peptide-specific T helper cells recognised the corresponding intact p21Ras protein. Ras peptides also induced CTL which were classical CD8+aTCR+ T cells. None of the CTL could distinguish mutant and normal Ras peptides. Interestingly, these CTL lysed peptide pulsed murine cells of several different H-2 haplotypes, indicating that recognition was not MHC class I allele restricted. However, the real peptide epitopes recognised by these unconventional CTL were not identified since Ras peptides were not very pure and stable, and undefined minor components might be responsible for the CTL responses. mH antigens cause rejection of MHC matched transplants. Bulk CTL responses were generated in H-2b mice differing in one (H-1), two (H-1 and H-25) or multiple (>29) mH loci, and HPLC purification was used to analyse the complexity of CTL recognised peptides. Both anti-H-1 and anti- H-l/H-25 CTL recognised one immunodominant epitope which was encoded by the H-1 locus and presented by H-2Kb molecules. Anti-multiple mH antigen CTL recognised the same H-1 locus derived epitope and another genetically undefined epitope which was presented by H-2Db molecules. Subfractionation of the CTL recognised HPLC fractions suggested that one mH locus encodes probably no more than one CTL epitope. Attempts were made to microsequence the CTL epitopes." @default.
• W3084447710 created "2020-09-21" @default.
• W3084447710 creator A5079553213 @default.
• W3084447710 date "1993-01-01" @default.
• W3084447710 modified "2023-09-23" @default.
• W3084447710 title "T cell recognition of endogenous and exogenous peptides presented by MHC molecules" @default.
• W3084447710 cites W1444462873 @default.
• W3084447710 cites W1487205233 @default.
• W3084447710 cites W1497774510 @default.
• W3084447710 cites W1510487353 @default.
• W3084447710 cites W1574892766 @default.
• W3084447710 cites W1601996991 @default.
• W3084447710 cites W1606013457 @default.
• W3084447710 cites W1760050006 @default.
• W3084447710 cites W1816753423 @default.
• W3084447710 cites W1891528462 @default.
• W3084447710 cites W1966393356 @default.
• W3084447710 cites W1968774879 @default.
• W3084447710 cites W1968932000 @default.
• W3084447710 cites W1969466114 @default.
• W3084447710 cites W1970654655 @default.
• W3084447710 cites W1971302107 @default.
• W3084447710 cites W1972873933 @default.
• W3084447710 cites W1975184547 @default.
• W3084447710 cites W1978359205 @default.
• W3084447710 cites W1979397217 @default.
• W3084447710 cites W1980120623 @default.
• W3084447710 cites W1985774274 @default.
• W3084447710 cites W1987752224 @default.
• W3084447710 cites W1988645175 @default.
• W3084447710 cites W1993446849 @default.
• W3084447710 cites W1994425461 @default.
• W3084447710 cites W1994435196 @default.
• W3084447710 cites W1995100965 @default.
• W3084447710 cites W1995129175 @default.
• W3084447710 cites W1995317534 @default.
• W3084447710 cites W1995482121 @default.
• W3084447710 cites W1995548577 @default.
• W3084447710 cites W1995656744 @default.
• W3084447710 cites W1996567630 @default.
• W3084447710 cites W1998135206 @default.
• W3084447710 cites W2000251753 @default.
• W3084447710 cites W2004118180 @default.
• W3084447710 cites W2004212058 @default.
• W3084447710 cites W2004813892 @default.
• W3084447710 cites W2005688001 @default.
• W3084447710 cites W2005914932 @default.
• W3084447710 cites W2006080840 @default.
• W3084447710 cites W2006293232 @default.
• W3084447710 cites W2006629564 @default.
• W3084447710 cites W2006987944 @default.
• W3084447710 cites W2007999146 @default.
• W3084447710 cites W2008437161 @default.
• W3084447710 cites W2008564146 @default.
• W3084447710 cites W2008611743 @default.
• W3084447710 cites W2009115410 @default.
• W3084447710 cites W2019993505 @default.
• W3084447710 cites W2022717713 @default.
• W3084447710 cites W2022861083 @default.
• W3084447710 cites W2023112048 @default.
• W3084447710 cites W2023308742 @default.
• W3084447710 cites W2024050392 @default.
• W3084447710 cites W2027306447 @default.
• W3084447710 cites W2029993034 @default.
• W3084447710 cites W2031006837 @default.
• W3084447710 cites W2031011895 @default.
• W3084447710 cites W2031101268 @default.
• W3084447710 cites W2031117778 @default.
• W3084447710 cites W2032225182 @default.
• W3084447710 cites W2032539159 @default.
• W3084447710 cites W2033370352 @default.
• W3084447710 cites W2033394004 @default.
• W3084447710 cites W2035470798 @default.
• W3084447710 cites W2036314272 @default.
• W3084447710 cites W2037260212 @default.
• W3084447710 cites W2038741016 @default.
• W3084447710 cites W2041128252 @default.
• W3084447710 cites W2041601304 @default.
• W3084447710 cites W2042583067 @default.
• W3084447710 cites W2042827525 @default.
• W3084447710 cites W2043745393 @default.
• W3084447710 cites W2044070030 @default.
• W3084447710 cites W2045787601 @default.
• W3084447710 cites W2047716932 @default.
• W3084447710 cites W2048017489 @default.
• W3084447710 cites W2048399127 @default.
• W3084447710 cites W2048542190 @default.
• W3084447710 cites W2050057789 @default.
• W3084447710 cites W2050637040 @default.
• W3084447710 cites W2050779244 @default.
• W3084447710 cites W2052736790 @default.
• W3084447710 cites W2053093244 @default.
• W3084447710 cites W2054185176 @default.
• W3084447710 cites W2055034075 @default.
• W3084447710 cites W2055220017 @default.
• W3084447710 cites W2056415484 @default.
• W3084447710 cites W2056524759 @default.
• W3084447710 cites W2056927502 @default.
• W3084447710 cites W2060954951 @default.
• W3084447710 cites W2061060052 @default.

• next