Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084487116> ?p ?o ?g. }
- W3084487116 endingPage "e0238717" @default.
- W3084487116 startingPage "e0238717" @default.
- W3084487116 abstract "Association between elevated cytokeratin 18 (CK-18) levels and hepatocyte death has made circulating CK-18 a candidate biomarker to differentiate non-alcoholic fatty liver from non-alcoholic steatohepatitis (NASH). Yet studies produced variable diagnostic performance. We aimed to provide summary estimates with increased precision for the accuracy of CK-18 (M30, M65) in detecting NASH and fibrosis among non-alcoholic fatty liver disease (NAFLD) adults.We searched five databases to retrieve studies evaluating CK-18 against a liver biopsy in NAFLD adults. Reference screening, data extraction and quality assessment (QUADAS-2) were independently conducted by two authors. Meta-analyses were performed for five groups based on the CK-18 antigens and target conditions, using one of two methods: linear mixed-effects multiple thresholds model or bivariate logit-normal random-effects model.We included 41 studies, with data on 5,815 participants. A wide range of disease prevalence was observed. No study reported a pre-defined cut-off. Thirty of 41 studies provided sufficient data for inclusion in any of the meta-analyses. Summary AUC [95% CI] were: 0.75 [0.69-0.82] (M30) and 0.82 [0.69-0.91] (M65) for NASH; 0.73 [0.57-0.85] (M30) for fibrotic NASH; 0.68 (M30) for significant (F2-4) fibrosis; and 0.75 (M30) for advanced (F3-4) fibrosis. Thirteen studies used CK-18 as a component of a multimarker model.For M30 we found lower diagnostic accuracy to detect NASH compared to previous meta-analyses, indicating a limited ability to act as a stand-alone test, with better performance for M65. Additional external validation studies are needed to obtain credible estimates of the diagnostic accuracy of multimarker models." @default.
- W3084487116 created "2020-09-21" @default.
- W3084487116 creator A5000392396 @default.
- W3084487116 creator A5006887486 @default.
- W3084487116 creator A5024082620 @default.
- W3084487116 creator A5039182719 @default.
- W3084487116 creator A5045590497 @default.
- W3084487116 creator A5053922719 @default.
- W3084487116 creator A5059068278 @default.
- W3084487116 creator A5061726857 @default.
- W3084487116 creator A5065731342 @default.
- W3084487116 creator A5072130761 @default.
- W3084487116 date "2020-09-11" @default.
- W3084487116 modified "2023-10-14" @default.
- W3084487116 title "Accuracy of cytokeratin 18 (M30 and M65) in detecting non-alcoholic steatohepatitis and fibrosis: A systematic review and meta-analysis" @default.
- W3084487116 cites W1509174047 @default.
- W3084487116 cites W1934701412 @default.
- W3084487116 cites W1936378503 @default.
- W3084487116 cites W1961783610 @default.
- W3084487116 cites W1964108702 @default.
- W3084487116 cites W1964572117 @default.
- W3084487116 cites W1972282906 @default.
- W3084487116 cites W1976571430 @default.
- W3084487116 cites W1980324550 @default.
- W3084487116 cites W1981623819 @default.
- W3084487116 cites W1988618773 @default.
- W3084487116 cites W1990710542 @default.
- W3084487116 cites W1999065994 @default.
- W3084487116 cites W2007781328 @default.
- W3084487116 cites W2013270845 @default.
- W3084487116 cites W2020862206 @default.
- W3084487116 cites W2022803835 @default.
- W3084487116 cites W2022956561 @default.
- W3084487116 cites W2023075325 @default.
- W3084487116 cites W2023914818 @default.
- W3084487116 cites W2025106732 @default.
- W3084487116 cites W2027287968 @default.
- W3084487116 cites W2033976455 @default.
- W3084487116 cites W2052151196 @default.
- W3084487116 cites W2056488785 @default.
- W3084487116 cites W2060847352 @default.
- W3084487116 cites W2067740038 @default.
- W3084487116 cites W2073137449 @default.
- W3084487116 cites W2086939368 @default.
- W3084487116 cites W2096045121 @default.
- W3084487116 cites W2101501858 @default.
- W3084487116 cites W2107638293 @default.
- W3084487116 cites W2113503022 @default.
- W3084487116 cites W2114486042 @default.
- W3084487116 cites W2126727011 @default.
- W3084487116 cites W2141866917 @default.
- W3084487116 cites W2145283527 @default.
- W3084487116 cites W2147372056 @default.
- W3084487116 cites W2156792510 @default.
- W3084487116 cites W2163803773 @default.
- W3084487116 cites W2168898273 @default.
- W3084487116 cites W2204688218 @default.
- W3084487116 cites W2267663625 @default.
- W3084487116 cites W2325047430 @default.
- W3084487116 cites W2337435850 @default.
- W3084487116 cites W2342197796 @default.
- W3084487116 cites W2557132626 @default.
- W3084487116 cites W257919409 @default.
- W3084487116 cites W2591257373 @default.
- W3084487116 cites W2610728861 @default.
- W3084487116 cites W2732221304 @default.
- W3084487116 cites W2761482659 @default.
- W3084487116 cites W2766148485 @default.
- W3084487116 cites W2782735473 @default.
- W3084487116 cites W2789288161 @default.
- W3084487116 cites W2790745956 @default.
- W3084487116 cites W2919371842 @default.
- W3084487116 cites W2920351734 @default.
- W3084487116 cites W2923781516 @default.
- W3084487116 cites W2968555719 @default.
- W3084487116 cites W2981266554 @default.
- W3084487116 cites W2983849523 @default.
- W3084487116 cites W3010545949 @default.
- W3084487116 cites W3143409077 @default.
- W3084487116 doi "https://doi.org/10.1371/journal.pone.0238717" @default.
- W3084487116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7485872" @default.
- W3084487116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32915852" @default.
- W3084487116 hasPublicationYear "2020" @default.
- W3084487116 type Work @default.
- W3084487116 sameAs 3084487116 @default.
- W3084487116 citedByCount "34" @default.
- W3084487116 countsByYear W30844871162021 @default.
- W3084487116 countsByYear W30844871162022 @default.
- W3084487116 countsByYear W30844871162023 @default.
- W3084487116 crossrefType "journal-article" @default.
- W3084487116 hasAuthorship W3084487116A5000392396 @default.
- W3084487116 hasAuthorship W3084487116A5006887486 @default.
- W3084487116 hasAuthorship W3084487116A5024082620 @default.
- W3084487116 hasAuthorship W3084487116A5039182719 @default.
- W3084487116 hasAuthorship W3084487116A5045590497 @default.
- W3084487116 hasAuthorship W3084487116A5053922719 @default.
- W3084487116 hasAuthorship W3084487116A5059068278 @default.
- W3084487116 hasAuthorship W3084487116A5061726857 @default.