Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084562162> ?p ?o ?g. }
- W3084562162 endingPage "671" @default.
- W3084562162 startingPage "659" @default.
- W3084562162 abstract "Anxiety disorders are among the most prevalent psychiatric disorders, causing significant suffering and disability. Behavioral inhibition is a temperament that is linked to an increased risk for the later development of anxiety disorders and other stress-related psychopathology, and understanding the neural systems underlying this dispositional risk could provide insight into novel treatment targets for anxiety disorders. Nonhuman primates (NHPs) have anxiety-related temperaments that are similar to those of humans with behavioral inhibition, facilitating the design of translational models related to human psychopathology. Characterization of our NHP model of behavioral inhibition, which we term anxious temperament (AT), reveals that it is trait-like. Exploration of the neural substrates of AT in NHPs has revealed a distributed neural circuit that is linked to individual differences in AT, which includes the dorsal amygdala. AT-related metabolism in the dorsal amygdala, including the central nucleus, is stable across time and can be detected even in safe contexts, suggesting that AT has trait-like neural signatures within the brain. The use of lesioning and novel chemogenetic methods allows for mechanistic perturbation of the amygdala to determine its causal contribution to AT. Studies characterizing the molecular bases for individual differences in AT in the dorsal amygdala, which take advantage of novel methods for probing cellular and molecular systems, suggest involvement of neurotrophic systems, which point to the importance of neuroplasticity in AT. These novel methods, when used in combination with translational NHP models such as AT, promise to provide insights into the brain systems underlying the early risk for anxiety disorder development." @default.
- W3084562162 created "2020-09-21" @default.
- W3084562162 creator A5062318456 @default.
- W3084562162 creator A5079573783 @default.
- W3084562162 date "2021-04-01" @default.
- W3084562162 modified "2023-10-13" @default.
- W3084562162 title "Nonhuman Primate Models to Explore Mechanisms Underlying Early-Life Temperamental Anxiety" @default.
- W3084562162 cites W1598678693 @default.
- W3084562162 cites W1607186674 @default.
- W3084562162 cites W1622056134 @default.
- W3084562162 cites W1670869140 @default.
- W3084562162 cites W1695265315 @default.
- W3084562162 cites W1738778520 @default.
- W3084562162 cites W1902471116 @default.
- W3084562162 cites W1941407864 @default.
- W3084562162 cites W1968714114 @default.
- W3084562162 cites W1972177155 @default.
- W3084562162 cites W1972227186 @default.
- W3084562162 cites W1975148201 @default.
- W3084562162 cites W1976512419 @default.
- W3084562162 cites W1977122833 @default.
- W3084562162 cites W1977259314 @default.
- W3084562162 cites W1977348028 @default.
- W3084562162 cites W1981044491 @default.
- W3084562162 cites W1981509058 @default.
- W3084562162 cites W1981654563 @default.
- W3084562162 cites W1983560277 @default.
- W3084562162 cites W1984506322 @default.
- W3084562162 cites W1989615119 @default.
- W3084562162 cites W1989982790 @default.
- W3084562162 cites W1990877586 @default.
- W3084562162 cites W1990942690 @default.
- W3084562162 cites W1990956630 @default.
- W3084562162 cites W1991766265 @default.
- W3084562162 cites W1993083986 @default.
- W3084562162 cites W1993630149 @default.
- W3084562162 cites W1995557073 @default.
- W3084562162 cites W1996678575 @default.
- W3084562162 cites W2000273941 @default.
- W3084562162 cites W2001193638 @default.
- W3084562162 cites W2001362807 @default.
- W3084562162 cites W2002027581 @default.
- W3084562162 cites W2003870213 @default.
- W3084562162 cites W2004787080 @default.
- W3084562162 cites W2005391290 @default.
- W3084562162 cites W2007856779 @default.
- W3084562162 cites W2008126685 @default.
- W3084562162 cites W2009140566 @default.
- W3084562162 cites W2009764368 @default.
- W3084562162 cites W2012367545 @default.
- W3084562162 cites W2013247351 @default.
- W3084562162 cites W2013500884 @default.
- W3084562162 cites W2023443471 @default.
- W3084562162 cites W2028010529 @default.
- W3084562162 cites W2030171111 @default.
- W3084562162 cites W2030480180 @default.
- W3084562162 cites W2032048939 @default.
- W3084562162 cites W2033211327 @default.
- W3084562162 cites W2034312988 @default.
- W3084562162 cites W2039789993 @default.
- W3084562162 cites W2043945427 @default.
- W3084562162 cites W2045122726 @default.
- W3084562162 cites W2045829947 @default.
- W3084562162 cites W2046369309 @default.
- W3084562162 cites W2048205572 @default.
- W3084562162 cites W2049117931 @default.
- W3084562162 cites W2049146026 @default.
- W3084562162 cites W2050925562 @default.
- W3084562162 cites W2057140640 @default.
- W3084562162 cites W2059359883 @default.
- W3084562162 cites W2063349862 @default.
- W3084562162 cites W2063535919 @default.
- W3084562162 cites W2064029491 @default.
- W3084562162 cites W2064278932 @default.
- W3084562162 cites W2064316672 @default.
- W3084562162 cites W2064896421 @default.
- W3084562162 cites W2065784037 @default.
- W3084562162 cites W2067411830 @default.
- W3084562162 cites W2071120710 @default.
- W3084562162 cites W2072159950 @default.
- W3084562162 cites W2074934796 @default.
- W3084562162 cites W2074950629 @default.
- W3084562162 cites W2075273444 @default.
- W3084562162 cites W2083433785 @default.
- W3084562162 cites W2087513003 @default.
- W3084562162 cites W2089100901 @default.
- W3084562162 cites W2089198034 @default.
- W3084562162 cites W2092421527 @default.
- W3084562162 cites W2094544368 @default.
- W3084562162 cites W2094899584 @default.
- W3084562162 cites W2097004047 @default.
- W3084562162 cites W2101523469 @default.
- W3084562162 cites W2101842006 @default.
- W3084562162 cites W2105394148 @default.
- W3084562162 cites W2106579385 @default.
- W3084562162 cites W2109309568 @default.
- W3084562162 cites W2109564832 @default.
- W3084562162 cites W2110696099 @default.