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- W3084570768 endingPage "2109" @default.
- W3084570768 startingPage "2109" @default.
- W3084570768 abstract "Vaccine design traditionally focuses on inducing adaptive immune responses against a sole target pathogen. Considering that many microbes evade innate immune mechanisms to initiate infection, and in light of the discovery of epigenetically mediated innate immune training, the paradigm of vaccine design has the potential to change. The Bacillus Calmette-Guérin (BCG) vaccine induces some level of protection against Mycobacterium tuberculosis (Mtb) while stimulating trained immunity that correlates with lower mortality and increased protection against unrelated pathogens. This review will explore BCG-induced trained immunity, including the required pathways to establish this phenotype. Additionally, potential methods to improve or expand BCG trained immunity effects through alternative vaccine delivery and formulation methods will be discussed. Finally, advances in new anti-Mtb vaccines, other antimicrobial uses for BCG, and “innate memory-based vaccines” will be examined." @default.
- W3084570768 created "2020-09-21" @default.
- W3084570768 creator A5082212379 @default.
- W3084570768 creator A5087401614 @default.
- W3084570768 date "2020-09-16" @default.
- W3084570768 modified "2023-10-17" @default.
- W3084570768 title "Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development" @default.
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- W3084570768 doi "https://doi.org/10.3390/cells9092109" @default.
- W3084570768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7564904" @default.
- W3084570768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32948003" @default.
- W3084570768 hasPublicationYear "2020" @default.
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