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• W3084577798 abstract "Abstract Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor-beta (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the epidermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct development of the nervous system." @default.
• W3084577798 created "2020-09-21" @default.
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• W3084577798 date "2020-09-15" @default.
• W3084577798 modified "2023-10-14" @default.
• W3084577798 title "Atypical TGF-β Signaling Controls Neuronal Guidance in<i>Caenorhabditis elegans</i>" @default.
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• W3084577798 doi "https://doi.org/10.1101/2020.09.15.297556" @default.
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