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- W3084578525 endingPage "110711" @default.
- W3084578525 startingPage "110711" @default.
- W3084578525 abstract "Idiopathic pulmonary fibrosis (IPF) is a chronic, fatal disease with high mortality and poor prognosis. It is characterized by a gradual decline in lung function, and there are currently no effective therapeutic methods. Folate is a water-soluble B vitamin that plays an important role in one-carbon transfer reactions, nucleic acid biosynthesis and methylation reactions. Studies have shown that folate may participate in the pathogenesis of IPF through ways of DNA repair, methylation, and reactive oxygen species. Macrophage activation is an important early cellular event in IPF and the inflammatory response that they trigger is a significant feature of IPF. Folate receptor-β (FR-β) is a cell surface glycosylphosphatidylinositol-anchored glycoprotein that can mediate the unidirectional transport of folate into cells. And it has been found in previous studies that FR-β is usually overexpressed on activated macrophages, but the expression on resting macrophages was undetectable. Therefore, targeting FR-β may have potential value for the early diagnosis and therapy of IPF. Our goal is to highlight the biological role of folate and FR-β in IPF, and we hope to provide helpful insight for clinical treatment strategies." @default.
- W3084578525 created "2020-09-21" @default.
- W3084578525 creator A5001530911 @default.
- W3084578525 creator A5031439376 @default.
- W3084578525 creator A5042524516 @default.
- W3084578525 creator A5067582026 @default.
- W3084578525 date "2020-11-01" @default.
- W3084578525 modified "2023-10-16" @default.
- W3084578525 title "Folate and macrophage folate receptor-β in idiopathic pulmonary fibrosis disease: the potential therapeutic target?" @default.
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