FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084632336> ?p ?o ?g. }

• W3084632336 abstract "Abstract Recently, we discovered a new glucogenic and centrally-acting orexigenic hormone – asprosin. Asprosin is elevated in metabolic syndrome (MS) patients, and importantly, its genetic loss results in reduced appetite, leanness and robust insulin sensitivity, leading to protection from MS. Here we demonstrate that anti-asprosin monoclonal antibodies (mAbs) are a dual-effect pharmacologic therapy that targets the two key pillars of MS – over-nutrition and the blood glucose burden. Anti-asprosin mAbs from three distinct species lowered appetite and body weight, and improved blood glucose in a dose-dependent and epitope-agnostic fashion in three independent MS mouse models, with an IC 50 of ∼1.5 mg/kg. In addition, mAb treatment ameliorated MS associated dyslipidemia and hepatic dysfunction. The mAbs displayed half-life of over 3 days in vivo, with equilibrium dissociation-constants in picomolar to low nanomolar range. This evidence paves the way for further development towards an investigational new drug application and subsequent human trials for treatment of MS, a defining physical ailment of our time." @default.
• W3084632336 created "2020-09-21" @default.
• W3084632336 creator A5009157591 @default.
• W3084632336 creator A5020215533 @default.
• W3084632336 creator A5026356376 @default.
• W3084632336 creator A5030544306 @default.
• W3084632336 creator A5031371352 @default.
• W3084632336 creator A5051159367 @default.
• W3084632336 creator A5056603678 @default.
• W3084632336 creator A5069142319 @default.
• W3084632336 creator A5086273781 @default.
• W3084632336 creator A5088609023 @default.
• W3084632336 date "2020-09-16" @default.
• W3084632336 modified "2023-09-26" @default.
• W3084632336 title "Asprosin Neutralizing Antibodies as a Treatment for Metabolic Syndrome" @default.
• W3084632336 cites W1985314055 @default.
• W3084632336 cites W2008289270 @default.
• W3084632336 cites W2014718725 @default.
• W3084632336 cites W2028266585 @default.
• W3084632336 cites W2050509217 @default.
• W3084632336 cites W2057948124 @default.
• W3084632336 cites W2106044600 @default.
• W3084632336 cites W2119812267 @default.
• W3084632336 cites W2728093281 @default.
• W3084632336 cites W2730267177 @default.
• W3084632336 cites W2744435745 @default.
• W3084632336 cites W2753968079 @default.
• W3084632336 cites W2765320067 @default.
• W3084632336 cites W2787530700 @default.
• W3084632336 cites W2793435470 @default.
• W3084632336 cites W2806708871 @default.
• W3084632336 cites W2899043265 @default.
• W3084632336 cites W2922156643 @default.
• W3084632336 cites W2925331589 @default.
• W3084632336 cites W2949364854 @default.
• W3084632336 cites W2950550620 @default.
• W3084632336 cites W2952612017 @default.
• W3084632336 cites W2966130021 @default.
• W3084632336 cites W2990880562 @default.
• W3084632336 doi "https://doi.org/10.1101/2020.09.15.298489" @default.
• W3084632336 hasPublicationYear "2020" @default.
• W3084632336 type Work @default.
• W3084632336 sameAs 3084632336 @default.
• W3084632336 citedByCount "0" @default.
• W3084632336 crossrefType "posted-content" @default.
• W3084632336 hasAuthorship W3084632336A5009157591 @default.
• W3084632336 hasAuthorship W3084632336A5020215533 @default.
• W3084632336 hasAuthorship W3084632336A5026356376 @default.
• W3084632336 hasAuthorship W3084632336A5030544306 @default.
• W3084632336 hasAuthorship W3084632336A5031371352 @default.
• W3084632336 hasAuthorship W3084632336A5051159367 @default.
• W3084632336 hasAuthorship W3084632336A5056603678 @default.
• W3084632336 hasAuthorship W3084632336A5069142319 @default.
• W3084632336 hasAuthorship W3084632336A5086273781 @default.
• W3084632336 hasAuthorship W3084632336A5088609023 @default.
• W3084632336 hasBestOaLocation W30846323361 @default.
• W3084632336 hasConcept C118303440 @default.
• W3084632336 hasConcept C126322002 @default.
• W3084632336 hasConcept C134018914 @default.
• W3084632336 hasConcept C150903083 @default.
• W3084632336 hasConcept C159654299 @default.
• W3084632336 hasConcept C170493617 @default.
• W3084632336 hasConcept C185592680 @default.
• W3084632336 hasConcept C195616568 @default.
• W3084632336 hasConcept C203014093 @default.
• W3084632336 hasConcept C207001950 @default.
• W3084632336 hasConcept C2777205416 @default.
• W3084632336 hasConcept C2778096610 @default.
• W3084632336 hasConcept C2780578515 @default.
• W3084632336 hasConcept C542903549 @default.
• W3084632336 hasConcept C555293320 @default.
• W3084632336 hasConcept C71924100 @default.
• W3084632336 hasConcept C75908981 @default.
• W3084632336 hasConcept C86803240 @default.
• W3084632336 hasConcept C93984277 @default.
• W3084632336 hasConcept C98274493 @default.
• W3084632336 hasConceptScore W3084632336C118303440 @default.
• W3084632336 hasConceptScore W3084632336C126322002 @default.
• W3084632336 hasConceptScore W3084632336C134018914 @default.
• W3084632336 hasConceptScore W3084632336C150903083 @default.
• W3084632336 hasConceptScore W3084632336C159654299 @default.
• W3084632336 hasConceptScore W3084632336C170493617 @default.
• W3084632336 hasConceptScore W3084632336C185592680 @default.
• W3084632336 hasConceptScore W3084632336C195616568 @default.
• W3084632336 hasConceptScore W3084632336C203014093 @default.
• W3084632336 hasConceptScore W3084632336C207001950 @default.
• W3084632336 hasConceptScore W3084632336C2777205416 @default.
• W3084632336 hasConceptScore W3084632336C2778096610 @default.
• W3084632336 hasConceptScore W3084632336C2780578515 @default.
• W3084632336 hasConceptScore W3084632336C542903549 @default.
• W3084632336 hasConceptScore W3084632336C555293320 @default.
• W3084632336 hasConceptScore W3084632336C71924100 @default.
• W3084632336 hasConceptScore W3084632336C75908981 @default.
• W3084632336 hasConceptScore W3084632336C86803240 @default.
• W3084632336 hasConceptScore W3084632336C93984277 @default.
• W3084632336 hasConceptScore W3084632336C98274493 @default.
• W3084632336 hasLocation W30846323361 @default.
• W3084632336 hasOpenAccess W3084632336 @default.
• W3084632336 hasPrimaryLocation W30846323361 @default.
• W3084632336 hasRelatedWork W1112780 @default.

• next