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- W3084656369 abstract "Structural changes in the corpus callosum have been reported in schizophrenia; however, the underlying molecular mechanism remains unclear. As the corpus callosum is high in lipid content, we analyzed the lipid contents of the corpora callosa from 15 patients with schizophrenia and 15 age- and sex-matched controls using liquid chromatography coupled to tandem mass spectrometry and identified lipid combinations associated with schizophrenia. Real-time quantitative polymerase chain reaction analyses using extended samples (schizophrenia, n = 95; control, n = 91) showed low expression levels of lipid metabolism-related genes and their potential upstream transcription factors in schizophrenia. Subsequent pathway analysis identified a gene regulatory network where nuclear factor of activated T cells 2 (NFATC2) is placed most upstream. We also observed low gene expression levels of microglial markers, inflammatory cytokines, and colony-stimulating factor 1 receptor (CSF1R), which is known to regulate the density of microglia, in the corpus callosum in schizophrenia. The interactions between CSF1R and several genes in the presently identified gene network originating from NFATC2 have been reported. Collectively, this study provides evidence regarding lipid abnormalities in the corpora callosa of patients with schizophrenia and proposes the potential role of impaired NFATC2-relevant gene network-microglial axis as its underlying mechanism." @default.
- W3084656369 created "2020-09-21" @default.
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- W3084656369 date "2020-09-14" @default.
- W3084656369 modified "2023-10-15" @default.
- W3084656369 title "Lipid Pathology of the Corpus Callosum in Schizophrenia and the Potential Role of Abnormal Gene Regulatory Networks with Reduced Microglial Marker Expression" @default.
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- W3084656369 doi "https://doi.org/10.1093/cercor/bhaa236" @default.
- W3084656369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7727339" @default.
- W3084656369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32924060" @default.
- W3084656369 hasPublicationYear "2020" @default.
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