FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084669567> ?p ?o ?g. }

• W3084669567 endingPage "102991" @default.
• W3084669567 startingPage "102991" @default.
• W3084669567 abstract "BackgroundA tetravalent live attenuated dengue vaccine, Dengvaxia, sensitised naïve recipients to severe dengue illness upon a subsequent natural dengue infection and is suspected to be due to antibody-dependent enhancement (ADE). ADE has also been implicated in the severe neurological outcomes of Zika virus (ZIKV) infection. It has become evident that cross-reactive antibodies targeting the viral pre-membrane protein and fusion-loop epitope are ADE-competent. A pre-clinical tetravalent dengue sub-unit vaccine candidate, DSV4, eliminates these ADE-competent epitopes.MethodsWe compared protective efficacy and ADE-competence of murine polyclonal antibodies induced by DSV4, Dengvaxia and an ‘in house’ tetravalent mixture of all four laboratory DENV strains, TV DENV, using established mouse models.FindingsDSV4-induced antibodies, known to be predominantly type-specific, provided significant protection against lethal DENV challenge, but did not promote ADE of either DENV or ZIKV infection in vivo. Antibodies elicited by Dengvaxia and TV DENV, which are predominantly cross-reactive, not only failed to offer protection against lethal DENV challenge, but also promoted ADE of both DENV and ZIKV infection in vivo.InterpretationProtective efficacy against DENV infection may be linked to the induction of neutralising antibodies which are type-specific rather than cross-reactive. Whole virus-based dengue vaccines may be associated with ADE risk, despite their potent virus-neutralising capacity. Vaccines designed to eliminate ADE-competent epitopes may help eliminate/minimise ADE risk.FundingThis study was supported partly by ICGEB, India, the National Biopharma Mission, DBT, Government of India, Sun Pharmaceutical Industries Limited, India, and NIAID, NIH, USA." @default.
• W3084669567 created "2020-09-21" @default.
• W3084669567 creator A5016268860 @default.
• W3084669567 creator A5032902187 @default.
• W3084669567 creator A5036568474 @default.
• W3084669567 creator A5045315402 @default.
• W3084669567 creator A5047879181 @default.
• W3084669567 creator A5057143834 @default.
• W3084669567 creator A5063140386 @default.
• W3084669567 creator A5071125492 @default.
• W3084669567 creator A5072286154 @default.
• W3084669567 creator A5072569824 @default.
• W3084669567 creator A5087169592 @default.
• W3084669567 creator A5087399775 @default.
• W3084669567 creator A5089283062 @default.
• W3084669567 creator A5091817295 @default.
• W3084669567 date "2020-10-01" @default.
• W3084669567 modified "2023-10-18" @default.
• W3084669567 title "Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models" @default.
• W3084669567 cites W1017348960 @default.
• W3084669567 cites W1482072302 @default.
• W3084669567 cites W1513149807 @default.
• W3084669567 cites W1599389506 @default.
• W3084669567 cites W1623942788 @default.
• W3084669567 cites W1777213512 @default.
• W3084669567 cites W1785302422 @default.
• W3084669567 cites W1893326865 @default.
• W3084669567 cites W1973587186 @default.
• W3084669567 cites W1985284043 @default.
• W3084669567 cites W1997966491 @default.
• W3084669567 cites W2006146542 @default.
• W3084669567 cites W2007480125 @default.
• W3084669567 cites W2012599139 @default.
• W3084669567 cites W2022037432 @default.
• W3084669567 cites W2022292268 @default.
• W3084669567 cites W2051298245 @default.
• W3084669567 cites W2052669763 @default.
• W3084669567 cites W2053490656 @default.
• W3084669567 cites W2058833815 @default.
• W3084669567 cites W2062414933 @default.
• W3084669567 cites W2076499360 @default.
• W3084669567 cites W2096608036 @default.
• W3084669567 cites W2100166387 @default.
• W3084669567 cites W2102144534 @default.
• W3084669567 cites W2111222009 @default.
• W3084669567 cites W2122228966 @default.
• W3084669567 cites W2131222241 @default.
• W3084669567 cites W2140737089 @default.
• W3084669567 cites W2141264905 @default.
• W3084669567 cites W2146980643 @default.
• W3084669567 cites W2150244847 @default.
• W3084669567 cites W2150348208 @default.
• W3084669567 cites W2151301904 @default.
• W3084669567 cites W2156495297 @default.
• W3084669567 cites W2179037755 @default.
• W3084669567 cites W2186465316 @default.
• W3084669567 cites W2192317075 @default.
• W3084669567 cites W2213311760 @default.
• W3084669567 cites W2272613784 @default.
• W3084669567 cites W2469258508 @default.
• W3084669567 cites W2470441796 @default.
• W3084669567 cites W2511423960 @default.
• W3084669567 cites W2594135889 @default.
• W3084669567 cites W2603610268 @default.
• W3084669567 cites W2611690321 @default.
• W3084669567 cites W2622446295 @default.
• W3084669567 cites W2734709769 @default.
• W3084669567 cites W2735191646 @default.
• W3084669567 cites W2736493714 @default.
• W3084669567 cites W2753483322 @default.
• W3084669567 cites W2760537022 @default.
• W3084669567 cites W2761752149 @default.
• W3084669567 cites W2763271218 @default.
• W3084669567 cites W2765619750 @default.
• W3084669567 cites W2772928063 @default.
• W3084669567 cites W2777057590 @default.
• W3084669567 cites W2783409826 @default.
• W3084669567 cites W2803273577 @default.
• W3084669567 cites W2807989886 @default.
• W3084669567 cites W2911726030 @default.
• W3084669567 cites W2942212503 @default.
• W3084669567 cites W2950420258 @default.
• W3084669567 cites W2987109794 @default.
• W3084669567 cites W3016712467 @default.
• W3084669567 doi "https://doi.org/10.1016/j.ebiom.2020.102991" @default.
• W3084669567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7501058" @default.
• W3084669567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32949997" @default.
• W3084669567 hasPublicationYear "2020" @default.
• W3084669567 type Work @default.
• W3084669567 sameAs 3084669567 @default.
• W3084669567 citedByCount "18" @default.
• W3084669567 countsByYear W30846695672020 @default.
• W3084669567 countsByYear W30846695672021 @default.
• W3084669567 countsByYear W30846695672022 @default.
• W3084669567 countsByYear W30846695672023 @default.
• W3084669567 crossrefType "journal-article" @default.
• W3084669567 hasAuthorship W3084669567A5016268860 @default.
• W3084669567 hasAuthorship W3084669567A5032902187 @default.

• next