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- W3084686839 abstract "Abstract The invasion of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Investigating the remodeling of local extracellular matrix (ECM) by invading cells can thus provide fundamental insights into the dynamics of cancer progression. In this paper, we use an active untethered nanomechanical tool, realized as magnetically driven nanomotors, to locally probe a 3D tissue culture environment. We observed that nanomotors preferentially adhere to the cancer‐proximal ECM and magnitude of the adhesive force increased with cell lines of higher metastatic ability. We experimentally confirmed that sialic acid linkage specific to cancer‐secreted ECM makes it differently charged, which causes this adhesion. In an assay consisting of both cancerous and non‐cancerous epithelia, that mimics the in vivo histopathological milieu of a malignant breast tumor, we find that nanomotors preferentially decorate the region around the cancer cells." @default.
- W3084686839 created "2020-09-21" @default.
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- W3084686839 date "2020-10-25" @default.
- W3084686839 modified "2023-10-13" @default.
- W3084686839 title "Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments**" @default.
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- W3084686839 doi "https://doi.org/10.1002/anie.202008681" @default.
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