Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084739147> ?p ?o ?g. }
- W3084739147 abstract "An ability to comprehensively track the assembly intermediates (AIs) of complex I (CI) biogenesis in Drosophila will enable the characterization of the precise mechanism(s) by which various CI regulators modulate CI assembly. Accordingly, we generated 21 novel antibodies to various mitochondrial proteins and used this resource to characterize the mechanism by which apoptosis-inducing factor (AIF) regulates CI biogenesis by tracking the AI profile observed when AIF expression is impaired. We find that when the AIF–Mia40 translocation complex is disrupted, the part of CI that transfers electrons to ubiquinone is synthesized but fails to progress in the CI biosynthetic pathway. This is associated with a reduction in intramitochondrial accumulation of the Mia40 substrate, MIC19. Importantly, knockdown of either MIC19 or MIC60, components of the mitochondrial contact site and cristae organizing system (MICOS), fully recapitulates the AI profile observed when AIF is inhibited. Thus, AIF’s effect on CI assembly is principally due to compromised intramitochondrial transport of the MICOS complex." @default.
- W3084739147 created "2020-09-21" @default.
- W3084739147 creator A5001583990 @default.
- W3084739147 creator A5039762691 @default.
- W3084739147 creator A5063375850 @default.
- W3084739147 creator A5066559427 @default.
- W3084739147 creator A5090658676 @default.
- W3084739147 date "2020-09-16" @default.
- W3084739147 modified "2023-10-14" @default.
- W3084739147 title "An antibody toolbox to track complex I assembly defines AIF’s mitochondrial function" @default.
- W3084739147 cites W1597316553 @default.
- W3084739147 cites W1840697242 @default.
- W3084739147 cites W1966928113 @default.
- W3084739147 cites W1999365156 @default.
- W3084739147 cites W2006070103 @default.
- W3084739147 cites W2014947131 @default.
- W3084739147 cites W2028925334 @default.
- W3084739147 cites W2031990165 @default.
- W3084739147 cites W2032413974 @default.
- W3084739147 cites W2046442704 @default.
- W3084739147 cites W2048743675 @default.
- W3084739147 cites W2059490316 @default.
- W3084739147 cites W2060517025 @default.
- W3084739147 cites W2064111855 @default.
- W3084739147 cites W2064853445 @default.
- W3084739147 cites W2102699819 @default.
- W3084739147 cites W2109435228 @default.
- W3084739147 cites W2110643873 @default.
- W3084739147 cites W2113431427 @default.
- W3084739147 cites W2125536365 @default.
- W3084739147 cites W2146675565 @default.
- W3084739147 cites W2155891625 @default.
- W3084739147 cites W2159650080 @default.
- W3084739147 cites W2164833592 @default.
- W3084739147 cites W2179054579 @default.
- W3084739147 cites W2317502035 @default.
- W3084739147 cites W2507486477 @default.
- W3084739147 cites W2520656712 @default.
- W3084739147 cites W2528211287 @default.
- W3084739147 cites W2730103937 @default.
- W3084739147 cites W2742348312 @default.
- W3084739147 cites W2802801856 @default.
- W3084739147 cites W2805245837 @default.
- W3084739147 cites W2806917274 @default.
- W3084739147 cites W2971376835 @default.
- W3084739147 doi "https://doi.org/10.1083/jcb.202001071" @default.
- W3084739147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7659709" @default.
- W3084739147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32936885" @default.
- W3084739147 hasPublicationYear "2020" @default.
- W3084739147 type Work @default.
- W3084739147 sameAs 3084739147 @default.
- W3084739147 citedByCount "27" @default.
- W3084739147 countsByYear W30847391472020 @default.
- W3084739147 countsByYear W30847391472021 @default.
- W3084739147 countsByYear W30847391472022 @default.
- W3084739147 countsByYear W30847391472023 @default.
- W3084739147 crossrefType "journal-article" @default.
- W3084739147 hasAuthorship W3084739147A5001583990 @default.
- W3084739147 hasAuthorship W3084739147A5039762691 @default.
- W3084739147 hasAuthorship W3084739147A5063375850 @default.
- W3084739147 hasAuthorship W3084739147A5066559427 @default.
- W3084739147 hasAuthorship W3084739147A5090658676 @default.
- W3084739147 hasBestOaLocation W30847391471 @default.
- W3084739147 hasConcept C104317684 @default.
- W3084739147 hasConcept C111472728 @default.
- W3084739147 hasConcept C131934819 @default.
- W3084739147 hasConcept C138885662 @default.
- W3084739147 hasConcept C172043667 @default.
- W3084739147 hasConcept C173396325 @default.
- W3084739147 hasConcept C190283241 @default.
- W3084739147 hasConcept C2777229759 @default.
- W3084739147 hasConcept C28859421 @default.
- W3084739147 hasConcept C31573885 @default.
- W3084739147 hasConcept C55493867 @default.
- W3084739147 hasConcept C86803240 @default.
- W3084739147 hasConcept C89611455 @default.
- W3084739147 hasConcept C95444343 @default.
- W3084739147 hasConcept C98424977 @default.
- W3084739147 hasConceptScore W3084739147C104317684 @default.
- W3084739147 hasConceptScore W3084739147C111472728 @default.
- W3084739147 hasConceptScore W3084739147C131934819 @default.
- W3084739147 hasConceptScore W3084739147C138885662 @default.
- W3084739147 hasConceptScore W3084739147C172043667 @default.
- W3084739147 hasConceptScore W3084739147C173396325 @default.
- W3084739147 hasConceptScore W3084739147C190283241 @default.
- W3084739147 hasConceptScore W3084739147C2777229759 @default.
- W3084739147 hasConceptScore W3084739147C28859421 @default.
- W3084739147 hasConceptScore W3084739147C31573885 @default.
- W3084739147 hasConceptScore W3084739147C55493867 @default.
- W3084739147 hasConceptScore W3084739147C86803240 @default.
- W3084739147 hasConceptScore W3084739147C89611455 @default.
- W3084739147 hasConceptScore W3084739147C95444343 @default.
- W3084739147 hasConceptScore W3084739147C98424977 @default.
- W3084739147 hasFunder F4320309418 @default.
- W3084739147 hasFunder F4320332161 @default.
- W3084739147 hasIssue "10" @default.
- W3084739147 hasLocation W30847391471 @default.
- W3084739147 hasLocation W30847391472 @default.
- W3084739147 hasOpenAccess W3084739147 @default.
- W3084739147 hasPrimaryLocation W30847391471 @default.