Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084889136> ?p ?o ?g. }
- W3084889136 endingPage "105199" @default.
- W3084889136 startingPage "105199" @default.
- W3084889136 abstract "Gastrointestinal (GI) cancers with a high incidence rate and adverse complications are related to severe morbidity and mortality around the world. MicroRNAs (miRs) are potential regulators of cellular events, and their aberrant expression occurs in gastrointestinal (GI) cancers. Increasing evidence demonstrates that plant derived-natural compounds are capable of regulation of miRs in cancer therapy. Curcumin is a naturally occurring nutraceutical compound isolated from curcuma longa and possesses valuable pharmacological activities in which anti-tumor activity is of importance, since in suppressing cancer malignancy, curcumin can target various molecular pathways such as STAT3, PTEN, PI3K/Akt, Wnt, and so on. In the present review, our aim is to shed some light on regulation of miRs by curcumin in GI cancers, and demonstrate how regulation of miRs by curcumin can affect proliferation and metastasis of GI cancers. Noteworthy, curcumin affects down-stream targets such as PTEN, VEGFA, PI3K/Akt and so on that are responsible for growth and migration of GI cancers via regulation of miRs. Affected miRs, and their down-stream targets are discussed in this review in a mechanistic way. Besides, challenges for clinical translation of current studies are described." @default.
- W3084889136 created "2020-09-21" @default.
- W3084889136 creator A5021535080 @default.
- W3084889136 creator A5029170591 @default.
- W3084889136 creator A5041093222 @default.
- W3084889136 creator A5058516379 @default.
- W3084889136 creator A5069750662 @default.
- W3084889136 creator A5070283845 @default.
- W3084889136 creator A5085120624 @default.
- W3084889136 creator A5090236421 @default.
- W3084889136 creator A5090838781 @default.
- W3084889136 date "2020-10-01" @default.
- W3084889136 modified "2023-10-09" @default.
- W3084889136 title "Sensing the scent of death: Modulation of microRNAs by Curcumin in gastrointestinal cancers" @default.
- W3084889136 cites W1604068141 @default.
- W3084889136 cites W1757407923 @default.
- W3084889136 cites W1877050407 @default.
- W3084889136 cites W1966059799 @default.
- W3084889136 cites W1967578143 @default.
- W3084889136 cites W1969270395 @default.
- W3084889136 cites W1971837077 @default.
- W3084889136 cites W1973354465 @default.
- W3084889136 cites W1976194786 @default.
- W3084889136 cites W1977191081 @default.
- W3084889136 cites W1980818370 @default.
- W3084889136 cites W1982313163 @default.
- W3084889136 cites W1985717888 @default.
- W3084889136 cites W1987252926 @default.
- W3084889136 cites W1994216821 @default.
- W3084889136 cites W1995850170 @default.
- W3084889136 cites W1999360191 @default.
- W3084889136 cites W2000044206 @default.
- W3084889136 cites W2001721754 @default.
- W3084889136 cites W2002995168 @default.
- W3084889136 cites W2019536742 @default.
- W3084889136 cites W2021018857 @default.
- W3084889136 cites W2022896276 @default.
- W3084889136 cites W2023827592 @default.
- W3084889136 cites W2031640592 @default.
- W3084889136 cites W2033007499 @default.
- W3084889136 cites W2047146433 @default.
- W3084889136 cites W2047188879 @default.
- W3084889136 cites W2047633497 @default.
- W3084889136 cites W2048496968 @default.
- W3084889136 cites W2050079849 @default.
- W3084889136 cites W2055897952 @default.
- W3084889136 cites W2059267594 @default.
- W3084889136 cites W2059978286 @default.
- W3084889136 cites W2065566217 @default.
- W3084889136 cites W2072940180 @default.
- W3084889136 cites W2073001877 @default.
- W3084889136 cites W2074596479 @default.
- W3084889136 cites W2075886750 @default.
- W3084889136 cites W2076248750 @default.
- W3084889136 cites W2077365696 @default.
- W3084889136 cites W2078950380 @default.
- W3084889136 cites W2080724286 @default.
- W3084889136 cites W2080958451 @default.
- W3084889136 cites W2081476178 @default.
- W3084889136 cites W2089466659 @default.
- W3084889136 cites W2089787496 @default.
- W3084889136 cites W2098390372 @default.
- W3084889136 cites W2099169332 @default.
- W3084889136 cites W2100736039 @default.
- W3084889136 cites W2105806975 @default.
- W3084889136 cites W2109227959 @default.
- W3084889136 cites W2113661251 @default.
- W3084889136 cites W2121058679 @default.
- W3084889136 cites W2121948013 @default.
- W3084889136 cites W2123324044 @default.
- W3084889136 cites W2123684526 @default.
- W3084889136 cites W2124580184 @default.
- W3084889136 cites W2126591541 @default.
- W3084889136 cites W2131687108 @default.
- W3084889136 cites W2132003677 @default.
- W3084889136 cites W2139992910 @default.
- W3084889136 cites W2142501544 @default.
- W3084889136 cites W2150041609 @default.
- W3084889136 cites W2151089147 @default.
- W3084889136 cites W2151101177 @default.
- W3084889136 cites W2158734599 @default.
- W3084889136 cites W2159430811 @default.
- W3084889136 cites W2167564369 @default.
- W3084889136 cites W2168584828 @default.
- W3084889136 cites W2168829937 @default.
- W3084889136 cites W2318716029 @default.
- W3084889136 cites W2407297331 @default.
- W3084889136 cites W2417060586 @default.
- W3084889136 cites W2480957117 @default.
- W3084889136 cites W2487786109 @default.
- W3084889136 cites W2507897093 @default.
- W3084889136 cites W2552091132 @default.
- W3084889136 cites W2559966901 @default.
- W3084889136 cites W2579340176 @default.
- W3084889136 cites W2588002261 @default.
- W3084889136 cites W2588324785 @default.
- W3084889136 cites W2605879403 @default.
- W3084889136 cites W2624149054 @default.