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• W3084936083 endingPage "16" @default.
• W3084936083 startingPage "1" @default.
• W3084936083 abstract "Hemophilia A and B are bleeding disorders caused by a deficiency of clotting factor VIII and IX, respectively. Patients with severe hemophilia (< 0.01 IU mL−1) and some patients with moderate hemophilia (0.01–0.05 IU mL−1) administer clotting factor concentrates prophylactically. Desmopressin (d-amino d-arginine vasopressin) can be applied in patients with non-severe hemophilia A. The aim of administration of factor concentrates or desmopressin is the prevention or cessation of bleeding. Despite weight-based dosing, it has been demonstrated that factor concentrates still exhibit considerable pharmacokinetic variability. Population pharmacokinetic analyses, in which this variability is quantified and explained, are increasingly performed in hemophilia research. These analyses can assist in the identification of important patient characteristics and can be applied to perform patient-tailored dosing. This review aims to present and discuss the population pharmacokinetic analyses that have been conducted to develop population pharmacokinetic models describing factor levels after administration of factor VIII or factor IX concentrates or d-amino d-arginine vasopressin. In total, 33 publications were retrieved from the literature. Two approaches were applied to perform population pharmacokinetic analyses, the standard two-stage approach and non-linear mixed-effect modeling. Using the standard two-stage approach, four population pharmacokinetic models were established describing factor VIII levels. In the remaining 29 analyses, the non-linear mixed-effect modeling approach was applied. NONMEM was the preferred software to establish population pharmacokinetic models. In total, 18 population pharmacokinetic analyses were conducted on the basis of data from a single product. From all available population pharmacokinetic analyses, 27 studies also included data from pediatric patients. In the majority of the population pharmacokinetic models, the population pharmacokinetic parameters were allometrically scaled using actual body weight. In this review, the available methods used for constructing the models, key features of these models, patient population characteristics, and established covariate relationships are described in detail." @default.
• W3084936083 created "2020-09-21" @default.
• W3084936083 creator A5002870795 @default.
• W3084936083 creator A5015860216 @default.
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• W3084936083 creator A5032190710 @default.
• W3084936083 creator A5043026808 @default.
• W3084936083 creator A5090296015 @default.
• W3084936083 date "2020-09-16" @default.
• W3084936083 modified "2023-10-17" @default.
• W3084936083 title "Population Pharmacokinetics of Clotting Factor Concentrates and Desmopressin in Hemophilia" @default.
• W3084936083 cites W14699937 @default.
• W3084936083 cites W1821399916 @default.
• W3084936083 cites W1963823583 @default.
• W3084936083 cites W1965987183 @default.
• W3084936083 cites W1968800426 @default.
• W3084936083 cites W1973228727 @default.
• W3084936083 cites W1973891097 @default.
• W3084936083 cites W1986601719 @default.
• W3084936083 cites W1989148484 @default.
• W3084936083 cites W2000741779 @default.
• W3084936083 cites W2004211552 @default.
• W3084936083 cites W2005769414 @default.
• W3084936083 cites W2006467528 @default.
• W3084936083 cites W2007881102 @default.
• W3084936083 cites W2008550866 @default.
• W3084936083 cites W2008823735 @default.
• W3084936083 cites W2014175398 @default.
• W3084936083 cites W2020123164 @default.
• W3084936083 cites W2020365240 @default.
• W3084936083 cites W2020804331 @default.
• W3084936083 cites W2023806093 @default.
• W3084936083 cites W2025615361 @default.
• W3084936083 cites W2029376301 @default.
• W3084936083 cites W2035387023 @default.
• W3084936083 cites W2038204041 @default.
• W3084936083 cites W2045886098 @default.
• W3084936083 cites W2047916181 @default.
• W3084936083 cites W2054251743 @default.
• W3084936083 cites W2059185356 @default.
• W3084936083 cites W2060289127 @default.
• W3084936083 cites W2067732954 @default.
• W3084936083 cites W2088316192 @default.
• W3084936083 cites W2088421586 @default.
• W3084936083 cites W2091277908 @default.
• W3084936083 cites W2091458190 @default.
• W3084936083 cites W2093123260 @default.
• W3084936083 cites W2094019929 @default.
• W3084936083 cites W2094455483 @default.
• W3084936083 cites W2095828288 @default.
• W3084936083 cites W2104922179 @default.
• W3084936083 cites W2106173868 @default.
• W3084936083 cites W2116866504 @default.
• W3084936083 cites W2120416054 @default.
• W3084936083 cites W2127277782 @default.
• W3084936083 cites W2127782011 @default.
• W3084936083 cites W2135223673 @default.
• W3084936083 cites W2145954506 @default.
• W3084936083 cites W2163200222 @default.
• W3084936083 cites W2165330647 @default.
• W3084936083 cites W2210754575 @default.
• W3084936083 cites W2284600747 @default.
• W3084936083 cites W2315516779 @default.
• W3084936083 cites W2463598524 @default.
• W3084936083 cites W2466900511 @default.
• W3084936083 cites W2510746161 @default.
• W3084936083 cites W2512222742 @default.
• W3084936083 cites W2540968481 @default.
• W3084936083 cites W2561843112 @default.
• W3084936083 cites W2589579553 @default.
• W3084936083 cites W2592750169 @default.
• W3084936083 cites W2600562065 @default.
• W3084936083 cites W2608266095 @default.
• W3084936083 cites W2732589685 @default.
• W3084936083 cites W2781841028 @default.
• W3084936083 cites W2788377675 @default.
• W3084936083 cites W2791162320 @default.
• W3084936083 cites W2791534802 @default.
• W3084936083 cites W2791704179 @default.
• W3084936083 cites W2793143008 @default.
• W3084936083 cites W2796766105 @default.
• W3084936083 cites W2801537337 @default.
• W3084936083 cites W2804950423 @default.
• W3084936083 cites W2891713080 @default.
• W3084936083 cites W2894432049 @default.
• W3084936083 cites W2910115629 @default.
• W3084936083 cites W2911945528 @default.
• W3084936083 cites W2920508490 @default.
• W3084936083 cites W2940559846 @default.
• W3084936083 cites W2942665937 @default.
• W3084936083 cites W2943583439 @default.
• W3084936083 cites W2944961426 @default.
• W3084936083 cites W2944969352 @default.
• W3084936083 cites W2949365580 @default.
• W3084936083 cites W2962540840 @default.
• W3084936083 cites W2969690755 @default.
• W3084936083 cites W3015258942 @default.

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