FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3084950662> ?p ?o ?g. }

• W3084950662 endingPage "2082" @default.
• W3084950662 startingPage "2082" @default.
• W3084950662 abstract "We have recently demonstrated that neural stem cell-based intravitreal co-administration of glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) confers profound protection to injured retinal ganglion cells (RGCs) in a mouse optic nerve crush model, resulting in the survival of ~38% RGCs two months after the nerve lesion. Here, we analyzed whether this neuroprotective effect is long-lasting and studied the impact of the pronounced RGC rescue on axonal regeneration. To this aim, we co-injected a GDNF- and a CNTF-overexpressing neural stem cell line into the vitreous cavity of adult mice one day after an optic nerve crush and determined the number of surviving RGCs 4, 6 and 8 months after the lesion. Remarkably, we found no significant decrease in the number of surviving RGCs between the successive analysis time points, indicating that the combined administration of GDNF and CNTF conferred lifelong protection to injured RGCs. While the simultaneous administration of GDNF and CNTF stimulated pronounced intraretinal axon growth when compared to retinas treated with either factor alone, numbers of regenerating axons in the distal optic nerve stumps were similar in animals co-treated with both factors and animals treated with CNTF only." @default.
• W3084950662 created "2020-09-21" @default.
• W3084950662 creator A5005211892 @default.
• W3084950662 creator A5007066894 @default.
• W3084950662 creator A5015721532 @default.
• W3084950662 creator A5023152752 @default.
• W3084950662 creator A5026527349 @default.
• W3084950662 creator A5052933885 @default.
• W3084950662 creator A5067320487 @default.
• W3084950662 creator A5090510422 @default.
• W3084950662 date "2020-09-11" @default.
• W3084950662 modified "2023-10-06" @default.
• W3084950662 title "Intravitreal Co-Administration of GDNF and CNTF Confers Synergistic and Long-Lasting Protection against Injury-Induced Cell Death of Retinal Ganglion Cells in Mice" @default.
• W3084950662 cites W1562834221 @default.
• W3084950662 cites W1591959848 @default.
• W3084950662 cites W1915963603 @default.
• W3084950662 cites W1965315078 @default.
• W3084950662 cites W1966085126 @default.
• W3084950662 cites W1969811289 @default.
• W3084950662 cites W1971208141 @default.
• W3084950662 cites W1971598496 @default.
• W3084950662 cites W1972955056 @default.
• W3084950662 cites W1973183757 @default.
• W3084950662 cites W1973576429 @default.
• W3084950662 cites W1973945718 @default.
• W3084950662 cites W1974178985 @default.
• W3084950662 cites W1976666379 @default.
• W3084950662 cites W1980217666 @default.
• W3084950662 cites W1981053922 @default.
• W3084950662 cites W1985235104 @default.
• W3084950662 cites W1985438725 @default.
• W3084950662 cites W1986527511 @default.
• W3084950662 cites W1986964725 @default.
• W3084950662 cites W1988860663 @default.
• W3084950662 cites W1991536078 @default.
• W3084950662 cites W2001568015 @default.
• W3084950662 cites W2003349524 @default.
• W3084950662 cites W2016796858 @default.
• W3084950662 cites W2018235103 @default.
• W3084950662 cites W2026400984 @default.
• W3084950662 cites W2026770509 @default.
• W3084950662 cites W2027759472 @default.
• W3084950662 cites W2039390487 @default.
• W3084950662 cites W2041189307 @default.
• W3084950662 cites W2049484831 @default.
• W3084950662 cites W2050065221 @default.
• W3084950662 cites W2053853398 @default.
• W3084950662 cites W2059323909 @default.
• W3084950662 cites W2059500485 @default.
• W3084950662 cites W2060128411 @default.
• W3084950662 cites W2065210378 @default.
• W3084950662 cites W2073973240 @default.
• W3084950662 cites W2078604606 @default.
• W3084950662 cites W2078647260 @default.
• W3084950662 cites W2085893808 @default.
• W3084950662 cites W2086333488 @default.
• W3084950662 cites W2095889022 @default.
• W3084950662 cites W2106533039 @default.
• W3084950662 cites W2118291472 @default.
• W3084950662 cites W2122565496 @default.
• W3084950662 cites W2139138449 @default.
• W3084950662 cites W2146819974 @default.
• W3084950662 cites W2147974112 @default.
• W3084950662 cites W2149208048 @default.
• W3084950662 cites W2150014868 @default.
• W3084950662 cites W2163583831 @default.
• W3084950662 cites W2168681404 @default.
• W3084950662 cites W2174781702 @default.
• W3084950662 cites W2189402995 @default.
• W3084950662 cites W2229551171 @default.
• W3084950662 cites W2248479811 @default.
• W3084950662 cites W2267051237 @default.
• W3084950662 cites W2279893865 @default.
• W3084950662 cites W2335690051 @default.
• W3084950662 cites W2426977738 @default.
• W3084950662 cites W2461272607 @default.
• W3084950662 cites W2621975946 @default.
• W3084950662 cites W2747505699 @default.
• W3084950662 cites W2788179764 @default.
• W3084950662 cites W2807292363 @default.
• W3084950662 cites W2857888574 @default.
• W3084950662 cites W2890112005 @default.
• W3084950662 cites W2892011387 @default.
• W3084950662 cites W2894302604 @default.
• W3084950662 cites W2895138297 @default.
• W3084950662 cites W2900491692 @default.
• W3084950662 cites W2987191560 @default.
• W3084950662 cites W3025176503 @default.
• W3084950662 cites W4210634607 @default.
• W3084950662 cites W4240661191 @default.
• W3084950662 doi "https://doi.org/10.3390/cells9092082" @default.
• W3084950662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7565883" @default.
• W3084950662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32932933" @default.
• W3084950662 hasPublicationYear "2020" @default.
• W3084950662 type Work @default.
• W3084950662 sameAs 3084950662 @default.
• W3084950662 citedByCount "15" @default.
• W3084950662 countsByYear W30849506622020 @default.

• next