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- W3084960678 endingPage "865" @default.
- W3084960678 startingPage "865" @default.
- W3084960678 abstract "Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid 2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine Nrf2/Keap1) signaling. Unlike the genetic changes affecting DNA sequence, the reversible nature of epigenetic alterations provides an attractive avenue for cancer interception. Thus, targeting epigenetic mechanisms in the corresponding signaling networks represents an enticing strategy for therapeutic intervention with dietary phytochemicals acting at transcriptional, post-transcriptional, and post-translational levels. This regulation involves the interplay of histone modifications and DNA methylation states in the human NFE2L2/KEAP1 and murine Nfe2l2/Keap1 genes, acetylation of lysine residues in NRF2 and Nrf2, interaction with bromodomain and extraterminal domain (BET) acetyl “reader” proteins, and non-coding RNAs such as microRNA (miRNA) and long non-coding RNA (lncRNA). Phytochemicals documented to modulate NRF2 signaling act by reversing hypermethylated states in the CpG islands of NFE2L2 or Nfe2l2, via the inhibition of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), through the induction of ten-eleven translocation (TET) enzymes, or by inducing miRNA to target the 3′-UTR of the corresponding mRNA transcripts. To date, fewer than twenty phytochemicals have been reported as NRF2 epigenetic modifiers, including curcumin, sulforaphane, resveratrol, reserpine, and ursolic acid. This opens avenues for exploring additional dietary phytochemicals that regulate the human epigenome, and the potential for novel strategies to target NRF2 signaling with a view to beneficial interception of cancer and other chronic diseases." @default.
- W3084960678 created "2020-09-21" @default.
- W3084960678 creator A5010123884 @default.
- W3084960678 creator A5082820494 @default.
- W3084960678 date "2020-09-14" @default.
- W3084960678 modified "2023-10-16" @default.
- W3084960678 title "Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals" @default.
- W3084960678 cites W110353796 @default.
- W3084960678 cites W1598950494 @default.
- W3084960678 cites W1632003291 @default.
- W3084960678 cites W177649821 @default.
- W3084960678 cites W1804809977 @default.
- W3084960678 cites W1912692550 @default.
- W3084960678 cites W1941294128 @default.
- W3084960678 cites W1951730546 @default.
- W3084960678 cites W1965431364 @default.
- W3084960678 cites W1967077010 @default.
- W3084960678 cites W1974546855 @default.
- W3084960678 cites W1975765810 @default.
- W3084960678 cites W1975773180 @default.
- W3084960678 cites W1976441209 @default.
- W3084960678 cites W1980439402 @default.
- W3084960678 cites W1980722224 @default.
- W3084960678 cites W1984396992 @default.
- W3084960678 cites W1991631628 @default.
- W3084960678 cites W1992724001 @default.
- W3084960678 cites W1998785193 @default.
- W3084960678 cites W1999273706 @default.
- W3084960678 cites W2000963773 @default.
- W3084960678 cites W2001761736 @default.
- W3084960678 cites W2003624918 @default.
- W3084960678 cites W2004051773 @default.
- W3084960678 cites W2004654818 @default.
- W3084960678 cites W2004840945 @default.
- W3084960678 cites W2005570632 @default.
- W3084960678 cites W2008121938 @default.
- W3084960678 cites W2011284050 @default.
- W3084960678 cites W2025801301 @default.
- W3084960678 cites W2029933341 @default.
- W3084960678 cites W2033019317 @default.
- W3084960678 cites W2035078285 @default.
- W3084960678 cites W2038014473 @default.
- W3084960678 cites W2044303805 @default.
- W3084960678 cites W2048608089 @default.
- W3084960678 cites W2053063855 @default.
- W3084960678 cites W2055021348 @default.
- W3084960678 cites W2055196208 @default.
- W3084960678 cites W2055573907 @default.
- W3084960678 cites W2056570827 @default.
- W3084960678 cites W2058310563 @default.
- W3084960678 cites W2058546993 @default.
- W3084960678 cites W2063637433 @default.
- W3084960678 cites W2065050615 @default.
- W3084960678 cites W2068232187 @default.
- W3084960678 cites W2069724423 @default.
- W3084960678 cites W2071100040 @default.
- W3084960678 cites W2078348655 @default.
- W3084960678 cites W2082789532 @default.
- W3084960678 cites W2084200591 @default.
- W3084960678 cites W2084284247 @default.
- W3084960678 cites W2085422374 @default.
- W3084960678 cites W2086354489 @default.
- W3084960678 cites W2087102857 @default.
- W3084960678 cites W2088381487 @default.
- W3084960678 cites W2090500595 @default.
- W3084960678 cites W2094546720 @default.
- W3084960678 cites W2096035514 @default.
- W3084960678 cites W2097634036 @default.
- W3084960678 cites W2104718696 @default.
- W3084960678 cites W2108164249 @default.
- W3084960678 cites W2108679460 @default.
- W3084960678 cites W2110122357 @default.
- W3084960678 cites W2113024198 @default.
- W3084960678 cites W2113209201 @default.
- W3084960678 cites W2114544044 @default.
- W3084960678 cites W2116828347 @default.
- W3084960678 cites W2118394016 @default.
- W3084960678 cites W2122116064 @default.
- W3084960678 cites W2122304932 @default.
- W3084960678 cites W2126401328 @default.
- W3084960678 cites W2126618982 @default.
- W3084960678 cites W2128998549 @default.
- W3084960678 cites W2135991329 @default.
- W3084960678 cites W2137667514 @default.
- W3084960678 cites W2138271341 @default.
- W3084960678 cites W2141116428 @default.
- W3084960678 cites W2142449962 @default.
- W3084960678 cites W2151820614 @default.
- W3084960678 cites W2152473190 @default.
- W3084960678 cites W2152937132 @default.
- W3084960678 cites W2153601430 @default.
- W3084960678 cites W2154587590 @default.
- W3084960678 cites W2157607726 @default.
- W3084960678 cites W2157981391 @default.
- W3084960678 cites W2159202696 @default.
- W3084960678 cites W2160611033 @default.
- W3084960678 cites W2161446823 @default.
- W3084960678 cites W2162798884 @default.