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• W3084967047 abstract "New classification systems based on molecular features have been introduced to improve precision medicine for prostate cancer (PCa). This review covers the increasing risk of PCa and the differences in response to targeted therapy that are related to specific gene variations. We believe that genomic evaluations will be useful for guiding PCa risk stratification, screening, and treatment. We searched the PubMed and MEDLINE databases for articles related to genomic testing for PCa that were published in 2020 or earlier. There is increasing evidence that germline mutations in DNA repair genes, such as BRCA1/2 or ATM, are closely related to the development and aggressiveness of PCa. Targeted prostate-specific antigen screening based on the presence of germline alterations in DNA repair genes is recommend to achieve an early diagnosis of PCa. In cases of localized PCa, even if it has a favorable risk classification, patients under active surveillance with these gene alterations are likely to develop aggressive PCa. Thus, active treatment may be preferable to active surveillance for these patients. In cases of metastatic castration-resistant PCa, BRCA1/2 and DNA mismatch repair genes may be useful biomarkers for predicting the response to androgen receptor-targeting agents, poly (ADP-ribose) polymerase inhibitors, platinum chemotherapy, prostate-specific membrane antigen-targeted therapy, immunotherapy, and radium-223. Genomic evaluations may allow for risk stratification of patients with PCa based on their molecular features, which may help guide precision medicine for treating PCa." @default.
• W3084967047 created "2020-09-21" @default.
• W3084967047 creator A5027920712 @default.
• W3084967047 creator A5052439030 @default.
• W3084967047 creator A5062256646 @default.
• W3084967047 date "2020-09-01" @default.
• W3084967047 modified "2023-10-01" @default.
• W3084967047 title "Clinical implications of genomic evaluations for prostate cancer risk stratification, screening, and treatment: a narrative review" @default.
• W3084967047 cites W1512405047 @default.
• W3084967047 cites W1578291413 @default.
• W3084967047 cites W1968785382 @default.
• W3084967047 cites W1972298018 @default.
• W3084967047 cites W1973268287 @default.
• W3084967047 cites W1989403098 @default.
• W3084967047 cites W1991778413 @default.
• W3084967047 cites W1998343146 @default.
• W3084967047 cites W2006157165 @default.
• W3084967047 cites W2009007206 @default.
• W3084967047 cites W2009454156 @default.
• W3084967047 cites W2022237123 @default.
• W3084967047 cites W2023011880 @default.
• W3084967047 cites W2028643667 @default.
• W3084967047 cites W2032346580 @default.
• W3084967047 cites W2033787957 @default.
• W3084967047 cites W2039211343 @default.
• W3084967047 cites W2043862114 @default.
• W3084967047 cites W2049355771 @default.
• W3084967047 cites W2051025382 @default.
• W3084967047 cites W2055482396 @default.
• W3084967047 cites W2064922460 @default.
• W3084967047 cites W2074824656 @default.
• W3084967047 cites W2087481500 @default.
• W3084967047 cites W2095658137 @default.
• W3084967047 cites W2106556127 @default.
• W3084967047 cites W2110534364 @default.
• W3084967047 cites W2111437716 @default.
• W3084967047 cites W2112211663 @default.
• W3084967047 cites W2116284235 @default.
• W3084967047 cites W2116353323 @default.
• W3084967047 cites W2119056140 @default.
• W3084967047 cites W2119308354 @default.
• W3084967047 cites W2121863482 @default.
• W3084967047 cites W2124194872 @default.
• W3084967047 cites W2126668914 @default.
• W3084967047 cites W2128659368 @default.
• W3084967047 cites W2130414070 @default.
• W3084967047 cites W2131357804 @default.
• W3084967047 cites W2136505615 @default.
• W3084967047 cites W2141454098 @default.
• W3084967047 cites W2142044692 @default.
• W3084967047 cites W2142795777 @default.
• W3084967047 cites W2148643283 @default.
• W3084967047 cites W2150095882 @default.
• W3084967047 cites W2151494814 @default.
• W3084967047 cites W2156923287 @default.
• W3084967047 cites W2160475700 @default.
• W3084967047 cites W2161112598 @default.
• W3084967047 cites W2166305340 @default.
• W3084967047 cites W2178232667 @default.
• W3084967047 cites W2205247948 @default.
• W3084967047 cites W2213675269 @default.
• W3084967047 cites W2235405584 @default.
• W3084967047 cites W2285063033 @default.
• W3084967047 cites W2287642617 @default.
• W3084967047 cites W2315998085 @default.
• W3084967047 cites W2393681916 @default.
• W3084967047 cites W2462985846 @default.
• W3084967047 cites W2477149045 @default.
• W3084967047 cites W2505088672 @default.
• W3084967047 cites W2510940971 @default.
• W3084967047 cites W2532226140 @default.
• W3084967047 cites W2564702165 @default.
• W3084967047 cites W2567290427 @default.
• W3084967047 cites W2567987817 @default.
• W3084967047 cites W2579423964 @default.
• W3084967047 cites W2593176248 @default.
• W3084967047 cites W2604062834 @default.
• W3084967047 cites W2612027160 @default.
• W3084967047 cites W2622499649 @default.
• W3084967047 cites W2626902876 @default.
• W3084967047 cites W2664930764 @default.
• W3084967047 cites W2752389930 @default.
• W3084967047 cites W2766866007 @default.
• W3084967047 cites W2772104639 @default.
• W3084967047 cites W2774213581 @default.
• W3084967047 cites W2786529129 @default.
• W3084967047 cites W2800517619 @default.
• W3084967047 cites W2892240038 @default.
• W3084967047 cites W2894805938 @default.
• W3084967047 cites W2896844652 @default.
• W3084967047 cites W2897403465 @default.
• W3084967047 cites W2897636829 @default.
• W3084967047 cites W2913612519 @default.
• W3084967047 cites W2915732659 @default.
• W3084967047 cites W2948919866 @default.
• W3084967047 cites W2954242906 @default.
• W3084967047 cites W2963473092 @default.
• W3084967047 cites W2972166775 @default.

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