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- W3084982301 endingPage "737" @default.
- W3084982301 startingPage "731" @default.
- W3084982301 abstract "As human skin hosts a diverse microbiota in health and disease, there is an emerging consensus that dysregulated interactions between host and microbiome may contribute to chronic inflammatory disease of the skin. Neonatal skin is a unique habitat, structurally similar to the adult but with a different profile of metabolic substrates, environmental stressors, and immune activity. The surface is colonized within moments of birth with a bias toward maternal strains. Initial colonists are outcompeted as environmental exposures increase and host skin matures. Nonetheless, early life microbial acquisitions may have long-lasting effects on health through modulation of host immunity and competitive interactions between bacteria. Microbial ecology and its influence on health have been of interest to dermatologists for >50 years, and an explosion of recent interest in the microbiome has prompted ongoing investigations of several microbial therapeutics for dermatological disease. In this review, we consider how recent insight into the host and microbial factors driving development of the skin microbiome in early life offers new opportunities for therapeutic intervention. IMPACT: Advancement in understanding molecular mechanisms of bacterial competition opens new avenues of investigation into dermatological disease. Primary development of the skin microbiome is determined by immunological features of the cutaneous habitat. Understanding coordinated microbial and immunological development in the pediatric patient requires a multidisciplinary synthesis of primary literature." @default.
- W3084982301 created "2020-09-21" @default.
- W3084982301 creator A5020095047 @default.
- W3084982301 creator A5080606540 @default.
- W3084982301 date "2020-09-12" @default.
- W3084982301 modified "2023-10-09" @default.
- W3084982301 title "Early development of the skin microbiome: therapeutic opportunities" @default.
- W3084982301 cites W1690293060 @default.
- W3084982301 cites W1782297065 @default.
- W3084982301 cites W1784135195 @default.
- W3084982301 cites W1915617735 @default.
- W3084982301 cites W1965924746 @default.
- W3084982301 cites W1967363561 @default.
- W3084982301 cites W1970703124 @default.
- W3084982301 cites W1971484356 @default.
- W3084982301 cites W1973829973 @default.
- W3084982301 cites W1978755563 @default.
- W3084982301 cites W1979077193 @default.
- W3084982301 cites W1979963523 @default.
- W3084982301 cites W1987287925 @default.
- W3084982301 cites W1988266369 @default.
- W3084982301 cites W1989889539 @default.
- W3084982301 cites W1994717300 @default.
- W3084982301 cites W1997792494 @default.
- W3084982301 cites W1999615949 @default.
- W3084982301 cites W2004690636 @default.
- W3084982301 cites W2005032514 @default.
- W3084982301 cites W2006737959 @default.
- W3084982301 cites W2007110604 @default.
- W3084982301 cites W2009170813 @default.
- W3084982301 cites W2012466364 @default.
- W3084982301 cites W2013470122 @default.
- W3084982301 cites W2014109392 @default.
- W3084982301 cites W2019378740 @default.
- W3084982301 cites W2020799333 @default.
- W3084982301 cites W2022221965 @default.
- W3084982301 cites W2023506796 @default.
- W3084982301 cites W2024843006 @default.
- W3084982301 cites W2026098461 @default.
- W3084982301 cites W2029038101 @default.
- W3084982301 cites W2029724364 @default.
- W3084982301 cites W2030927736 @default.
- W3084982301 cites W2031197510 @default.
- W3084982301 cites W2032893178 @default.
- W3084982301 cites W2036495967 @default.
- W3084982301 cites W2039467079 @default.
- W3084982301 cites W2039989168 @default.
- W3084982301 cites W2047774330 @default.
- W3084982301 cites W2050129933 @default.
- W3084982301 cites W2050495196 @default.
- W3084982301 cites W2054988385 @default.
- W3084982301 cites W2056960236 @default.
- W3084982301 cites W2061058478 @default.
- W3084982301 cites W2061849001 @default.
- W3084982301 cites W2063177628 @default.
- W3084982301 cites W2066021029 @default.
- W3084982301 cites W2068252130 @default.
- W3084982301 cites W2069445046 @default.
- W3084982301 cites W2072417345 @default.
- W3084982301 cites W2073247934 @default.
- W3084982301 cites W2080370306 @default.
- W3084982301 cites W2083731566 @default.
- W3084982301 cites W2084057318 @default.
- W3084982301 cites W2086697405 @default.
- W3084982301 cites W2088533694 @default.
- W3084982301 cites W2089705909 @default.
- W3084982301 cites W2089840435 @default.
- W3084982301 cites W2094862108 @default.
- W3084982301 cites W2097590976 @default.
- W3084982301 cites W2099780103 @default.
- W3084982301 cites W2106732573 @default.
- W3084982301 cites W2107097628 @default.
- W3084982301 cites W2108195091 @default.
- W3084982301 cites W2108687405 @default.
- W3084982301 cites W2112059874 @default.
- W3084982301 cites W2112496485 @default.
- W3084982301 cites W2112522166 @default.
- W3084982301 cites W2116846792 @default.
- W3084982301 cites W2124535041 @default.
- W3084982301 cites W2125832470 @default.
- W3084982301 cites W2126804376 @default.
- W3084982301 cites W2127778327 @default.
- W3084982301 cites W2130725058 @default.
- W3084982301 cites W2136984408 @default.
- W3084982301 cites W2137195441 @default.
- W3084982301 cites W2139009894 @default.
- W3084982301 cites W2143459823 @default.
- W3084982301 cites W2143777796 @default.
- W3084982301 cites W2147681319 @default.
- W3084982301 cites W2153248731 @default.
- W3084982301 cites W2156071020 @default.
- W3084982301 cites W2162088497 @default.
- W3084982301 cites W2166873510 @default.
- W3084982301 cites W2180997009 @default.
- W3084982301 cites W2182177864 @default.
- W3084982301 cites W2262659360 @default.
- W3084982301 cites W2277122287 @default.
- W3084982301 cites W2280112126 @default.