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• W3085004471 endingPage "104482" @default.
• W3085004471 startingPage "104482" @default.
• W3085004471 abstract "Enterococcus faecalis is a biofilm-forming, nosocomial pathogen that is frequently isolated from failed root canal treatments. Contemporary root canal disinfectants are ineffective in eliminating these biofilms and preventing reinfection. As a result, there is a pressing need to identify novel and safe antibiofilm molecules. The effect of short-term (5 and 15 min) and long-term (24 h) treatments of trans-cinnamaldehyde (TC) on the viability of E. faecalis biofilms was compared with currently used root canal disinfectants. Treatment for 15 min with TC reduced biofilm metabolic activity as effective as 1% sodium hypochlorite and 2% chlorhexidine. Treatment with TC for 24 h was significantly more effective than 2% chlorhexidine in reducing the viable cell counts of biofilms. This serendipitous effect of TC was sustained for 10 days under growth-favoring conditions. For the first time, our study highlights the strong antibacterial activity of TC against E. faecalis biofilms, and notably, its ability to prevent biofilm recovery after treatment." @default.
• W3085004471 created "2020-09-21" @default.
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• W3085004471 date "2020-12-01" @default.
• W3085004471 modified "2023-10-17" @default.
• W3085004471 title "Trans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery" @default.
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• W3085004471 doi "https://doi.org/10.1016/j.micpath.2020.104482" @default.
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