Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085092413> ?p ?o ?g. }
- W3085092413 endingPage "82" @default.
- W3085092413 startingPage "68" @default.
- W3085092413 abstract "Current drug development efforts for the treatment of atrial fibrillation are hampered by the fact that many preclinical models have been unsuccessful in reproducing human cardiac physiology and its response to medications. In this study, we demonstrated an approach using human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes (hiPSC-aCMs and hiPSC-vCMs, respectively) coupled with a sophisticated optical mapping system for drug screening of atrial-selective compounds in vitro. We optimized differentiation of hiPSC-aCMs by modulating the WNT and retinoid signaling pathways. Characterization of the transcriptome and proteome revealed that retinoic acid pushes the differentiation process into the atrial lineage and generated hiPSC-aCMs. Functional characterization using optical mapping showed that hiPSC-aCMs have shorter action potential durations and faster Ca2+ handling dynamics compared with hiPSC-vCMs. Furthermore, pharmacological investigation of hiPSC-aCMs captured atrial-selective effects by displaying greater sensitivity to atrial-selective compounds 4-aminopyridine, AVE0118, UCL1684, and vernakalant when compared with hiPSC-vCMs. These results established that a model system incorporating hiPSC-aCMs combined with optical mapping is well-suited for preclinical drug screening of novel and targeted atrial selective compounds." @default.
- W3085092413 created "2020-09-21" @default.
- W3085092413 creator A5012158443 @default.
- W3085092413 creator A5012813553 @default.
- W3085092413 creator A5021073765 @default.
- W3085092413 creator A5022004647 @default.
- W3085092413 creator A5027812098 @default.
- W3085092413 creator A5057815632 @default.
- W3085092413 creator A5067460303 @default.
- W3085092413 creator A5069610108 @default.
- W3085092413 date "2020-09-14" @default.
- W3085092413 modified "2023-09-26" @default.
- W3085092413 title "Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping" @default.
- W3085092413 cites W1861426701 @default.
- W3085092413 cites W1907511822 @default.
- W3085092413 cites W1972530481 @default.
- W3085092413 cites W1975540620 @default.
- W3085092413 cites W1981853673 @default.
- W3085092413 cites W1995577804 @default.
- W3085092413 cites W1995830102 @default.
- W3085092413 cites W2025249827 @default.
- W3085092413 cites W2066390373 @default.
- W3085092413 cites W2069568172 @default.
- W3085092413 cites W2073049800 @default.
- W3085092413 cites W2083599207 @default.
- W3085092413 cites W2090122064 @default.
- W3085092413 cites W2091200101 @default.
- W3085092413 cites W2100904299 @default.
- W3085092413 cites W2111174244 @default.
- W3085092413 cites W2117386147 @default.
- W3085092413 cites W2120328369 @default.
- W3085092413 cites W2125912562 @default.
- W3085092413 cites W2126543195 @default.
- W3085092413 cites W2129156306 @default.
- W3085092413 cites W2133127571 @default.
- W3085092413 cites W2185842802 @default.
- W3085092413 cites W2519910568 @default.
- W3085092413 cites W2548555003 @default.
- W3085092413 cites W2575450718 @default.
- W3085092413 cites W2600402345 @default.
- W3085092413 cites W2733298659 @default.
- W3085092413 cites W2737339218 @default.
- W3085092413 cites W2742550673 @default.
- W3085092413 cites W2802249171 @default.
- W3085092413 cites W2802441329 @default.
- W3085092413 cites W2809013388 @default.
- W3085092413 cites W2825606663 @default.
- W3085092413 cites W2892252377 @default.
- W3085092413 cites W2924877007 @default.
- W3085092413 cites W2941130110 @default.
- W3085092413 cites W3085092413 @default.
- W3085092413 cites W4211135485 @default.
- W3085092413 doi "https://doi.org/10.1002/sctm.19-0440" @default.
- W3085092413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7780813" @default.
- W3085092413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32927497" @default.
- W3085092413 hasPublicationYear "2020" @default.
- W3085092413 type Work @default.
- W3085092413 sameAs 3085092413 @default.
- W3085092413 citedByCount "19" @default.
- W3085092413 countsByYear W30850924132020 @default.
- W3085092413 countsByYear W30850924132021 @default.
- W3085092413 countsByYear W30850924132022 @default.
- W3085092413 countsByYear W30850924132023 @default.
- W3085092413 crossrefType "journal-article" @default.
- W3085092413 hasAuthorship W3085092413A5012158443 @default.
- W3085092413 hasAuthorship W3085092413A5012813553 @default.
- W3085092413 hasAuthorship W3085092413A5021073765 @default.
- W3085092413 hasAuthorship W3085092413A5022004647 @default.
- W3085092413 hasAuthorship W3085092413A5027812098 @default.
- W3085092413 hasAuthorship W3085092413A5057815632 @default.
- W3085092413 hasAuthorship W3085092413A5067460303 @default.
- W3085092413 hasAuthorship W3085092413A5069610108 @default.
- W3085092413 hasBestOaLocation W30850924131 @default.
- W3085092413 hasConcept C104317684 @default.
- W3085092413 hasConcept C107459253 @default.
- W3085092413 hasConcept C137620995 @default.
- W3085092413 hasConcept C145103041 @default.
- W3085092413 hasConcept C150194340 @default.
- W3085092413 hasConcept C162317418 @default.
- W3085092413 hasConcept C185592680 @default.
- W3085092413 hasConcept C2780035454 @default.
- W3085092413 hasConcept C2781121885 @default.
- W3085092413 hasConcept C55493867 @default.
- W3085092413 hasConcept C60644358 @default.
- W3085092413 hasConcept C62478195 @default.
- W3085092413 hasConcept C71924100 @default.
- W3085092413 hasConcept C74187038 @default.
- W3085092413 hasConcept C86803240 @default.
- W3085092413 hasConcept C95444343 @default.
- W3085092413 hasConcept C98274493 @default.
- W3085092413 hasConceptScore W3085092413C104317684 @default.
- W3085092413 hasConceptScore W3085092413C107459253 @default.
- W3085092413 hasConceptScore W3085092413C137620995 @default.
- W3085092413 hasConceptScore W3085092413C145103041 @default.
- W3085092413 hasConceptScore W3085092413C150194340 @default.
- W3085092413 hasConceptScore W3085092413C162317418 @default.
- W3085092413 hasConceptScore W3085092413C185592680 @default.
- W3085092413 hasConceptScore W3085092413C2780035454 @default.