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• W3085130314 endingPage "e0238066" @default.
• W3085130314 startingPage "e0238066" @default.
• W3085130314 abstract "Oxidative stress (OS) plays a marked role in aging and results from a variety of stressors, making it a powerful measure of health and a way to examine costs associated with life history investments within and across species. However, few urinary OS markers have been examined under field conditions, particularly in primates, and their utility to non-invasively monitor the costs of acute stressors versus the long-term damage associated with aging is poorly understood. In this study, we examined variation in 5 urinary markers of oxidative damage and protection under 5 validation paradigms for 37 wild, chimpanzees living in the Kibale National Park, Uganda. We used 924 urine samples to examine responses to acute immune challenge (respiratory illness or severe wounding), as well as mixed-longitudinal and intra-individual variation with age. DNA damage (8-OHdG) correlated positively with all other markers of damage (F-isoprostanes, MDA-TBARS, and neopterin) but did not correlate with protection (total antioxidant capacity). Within individuals, all markers of damage responded to at least one if not both types of acute infection. While OS is expected to increase with age, this was not generally true in chimpanzees. However, significant changes in oxidative damage were detected within past-prime individuals and those close to death. Our results indicate that OS can be measured using field-collected urine and integrates short- and long-term aspects of health. They further suggest that more data are needed from long-lived, wild animals to illuminate if common age-related increases in inflammation and OS damage are typical or recently aberrant in humans." @default.
• W3085130314 created "2020-09-21" @default.
• W3085130314 creator A5019517540 @default.
• W3085130314 creator A5024273439 @default.
• W3085130314 creator A5046447938 @default.
• W3085130314 creator A5064925911 @default.
• W3085130314 creator A5071739156 @default.
• W3085130314 creator A5087201179 @default.
• W3085130314 date "2020-09-11" @default.
• W3085130314 modified "2023-10-14" @default.
• W3085130314 title "Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees" @default.
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