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- W3085184190 abstract "Significance So far, no targeted therapy has been approved for KRAS mutant tumors. We report that combined genetic inactivation of CDK4 and RAF1 in advanced KRAS/p53 mutant lung tumors leads to effective tumor regression without inducing significant toxicities. In spite of this therapeutic response, CDK4/RAF1-resistant cells appeared. We have identified and pharmacologically validated two independent resistance mechanisms involving hypermethylation of tumor-suppressor genes and activation of the PI3K pathway." @default.
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- W3085184190 date "2020-09-10" @default.
- W3085184190 modified "2023-10-18" @default.
- W3085184190 title "Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas" @default.
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- W3085184190 doi "https://doi.org/10.1073/pnas.2002520117" @default.
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