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• W3085194795 endingPage "4214" @default.
• W3085194795 startingPage "4214" @default.
• W3085194795 abstract "Dental caries or tooth decay is a preventable and multifactorial disease that affects billions of people globally and is a particular concern in younger populations. This decay arises from acid demineralisation of tooth enamel resulting in mineral loss from the subsurface. The remineralisation of early enamel carious lesions could prevent the cavitation of teeth. The enamel protein amelogenin constitutes 90% of the total enamel matrix protein in teeth and plays a key role in the biomineralisation of tooth enamel. The physiological importance of amelogenin has led to the investigation of the possible development of amelogenin-derived biomimetics against dental caries. We herein review the literature on amelogenin, its primary and secondary structure, comparison to related species, and its’ in vivo processing to bioactive peptide fragments. The key structural motifs of amelogenin that enable enamel remineralisation are discussed. The presence of several motifs in the amelogenin structure (such as polyproline, N- and C-terminal domains and C-terminal orientation) were shown to play a critical role in the formation of particle shape during remineralization. Understanding the function/structure relationships of amelogenin can aid in the rational design of synthetic polypeptides for biomineralisation, halting enamel loss and leading to improved therapies for tooth decay." @default.
• W3085194795 created "2020-09-21" @default.
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• W3085194795 date "2020-09-14" @default.
• W3085194795 modified "2023-10-17" @default.
• W3085194795 title "Identification of Key Functional Motifs of Native Amelogenin Protein for Dental Enamel Remineralisation" @default.
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• W3085194795 cites W1872198448 @default.
• W3085194795 cites W1956299500 @default.
• W3085194795 cites W1964162140 @default.
• W3085194795 cites W1967206429 @default.
• W3085194795 cites W1967222779 @default.
• W3085194795 cites W1969674072 @default.
• W3085194795 cites W1971625591 @default.
• W3085194795 cites W1974711510 @default.
• W3085194795 cites W1978043936 @default.
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• W3085194795 doi "https://doi.org/10.3390/molecules25184214" @default.
• W3085194795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7571260" @default.
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• W3085194795 hasPublicationYear "2020" @default.
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