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- W3085304039 endingPage "2075" @default.
- W3085304039 startingPage "2075" @default.
- W3085304039 abstract "Stroke is a life-threatening disease that leads to mortality, with survivors subjected to long-term disability. Microvascular damage is implicated as a key pathological feature, as well as a therapeutic target for stroke. In this review, we present evidence detailing subacute diaschisis in a focal ischemic stroke rat model with a focus on blood–brain barrier (BBB) integrity and related pathogenic processes in contralateral brain areas. Additionally, we discuss BBB competence in chronic diaschisis in a similar rat stroke model, highlighting the pathological changes in contralateral brain areas that indicate progressive morphological brain disturbances overtime after stroke onset. With diaschisis closely approximating stroke onset and progression, it stands as a treatment of interest for stroke. Indeed, the use of stem cell transplantation for the repair of microvascular damage has been investigated, demonstrating that bone marrow stem cells intravenously transplanted into rats 48 h post-stroke survive and integrate into the microvasculature. Ultrastructural analysis of transplanted stroke brains reveals that microvessels display a near-normal morphology of endothelial cells and their mitochondria. Cell-based therapeutics represent a new mechanism in BBB and microvascular repair for stroke." @default.
- W3085304039 created "2020-09-21" @default.
- W3085304039 creator A5003708505 @default.
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- W3085304039 creator A5084829928 @default.
- W3085304039 date "2020-09-11" @default.
- W3085304039 modified "2023-09-26" @default.
- W3085304039 title "Stem Cell Repair of the Microvascular Damage in Stroke" @default.
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