Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085312448> ?p ?o ?g. }
- W3085312448 endingPage "17113" @default.
- W3085312448 startingPage "17099" @default.
- W3085312448 abstract "SIRT6, a nuclear protein, has been implicated in a number of essential cellular processes, such as the DNA damage response, metabolic homeostasis, inflammation, tumorigenesis and aging. However, the role of Sirt6 in the regulation of spermatogenesis is yet unknown. In the present study, we successfully generated Sirt6-/- mice on a C57BL6/ICR mixed background and found that some Sirt6-/- mice survived beyond eight weeks. We further revealed that spermatogenesis in Sirt6-/- mice was arrested at the elongated spermatid stage. Sirt6-/- male mice were completely infertile and had an increased number of apoptotic spermatids. To our surprise, deacetylation activities of SIRT6 on H3K9ac, H3K18ac and H3K56c were not required for spermatogenesis. Therefore, our findings establish a novel link between Sirt6 and male fertility, suggesting an essential role of Sirt6 in spermatogenesis." @default.
- W3085312448 created "2020-09-21" @default.
- W3085312448 creator A5000432967 @default.
- W3085312448 creator A5013734736 @default.
- W3085312448 creator A5028296024 @default.
- W3085312448 creator A5042947574 @default.
- W3085312448 creator A5054459491 @default.
- W3085312448 creator A5062281323 @default.
- W3085312448 creator A5080454453 @default.
- W3085312448 creator A5083418447 @default.
- W3085312448 date "2020-09-11" @default.
- W3085312448 modified "2023-10-07" @default.
- W3085312448 title "Sirt6 is required for spermatogenesis in mice" @default.
- W3085312448 cites W1480699894 @default.
- W3085312448 cites W1551636680 @default.
- W3085312448 cites W1564224574 @default.
- W3085312448 cites W1830081733 @default.
- W3085312448 cites W1969480537 @default.
- W3085312448 cites W1974231851 @default.
- W3085312448 cites W1981549228 @default.
- W3085312448 cites W1983735042 @default.
- W3085312448 cites W1985834536 @default.
- W3085312448 cites W1986571649 @default.
- W3085312448 cites W1994540097 @default.
- W3085312448 cites W2001396107 @default.
- W3085312448 cites W2002454928 @default.
- W3085312448 cites W2019110420 @default.
- W3085312448 cites W2029969982 @default.
- W3085312448 cites W2034845115 @default.
- W3085312448 cites W2041552603 @default.
- W3085312448 cites W2041671300 @default.
- W3085312448 cites W2041959419 @default.
- W3085312448 cites W2042716686 @default.
- W3085312448 cites W2044578262 @default.
- W3085312448 cites W2044836637 @default.
- W3085312448 cites W2054866841 @default.
- W3085312448 cites W2055373932 @default.
- W3085312448 cites W2064802388 @default.
- W3085312448 cites W2076105902 @default.
- W3085312448 cites W2077436902 @default.
- W3085312448 cites W2079679058 @default.
- W3085312448 cites W2080055581 @default.
- W3085312448 cites W2084707133 @default.
- W3085312448 cites W2097948853 @default.
- W3085312448 cites W2099974711 @default.
- W3085312448 cites W2105702352 @default.
- W3085312448 cites W2106715610 @default.
- W3085312448 cites W2109560454 @default.
- W3085312448 cites W2123272922 @default.
- W3085312448 cites W2123927456 @default.
- W3085312448 cites W2126187754 @default.
- W3085312448 cites W2139449514 @default.
- W3085312448 cites W2147458179 @default.
- W3085312448 cites W2160402200 @default.
- W3085312448 cites W2170498202 @default.
- W3085312448 cites W2170510597 @default.
- W3085312448 cites W2293979620 @default.
- W3085312448 cites W2302170510 @default.
- W3085312448 cites W2374078013 @default.
- W3085312448 cites W2526861327 @default.
- W3085312448 cites W2561386110 @default.
- W3085312448 cites W2593515715 @default.
- W3085312448 cites W2597939397 @default.
- W3085312448 cites W2612483794 @default.
- W3085312448 cites W2788358081 @default.
- W3085312448 cites W2789687467 @default.
- W3085312448 cites W2888046743 @default.
- W3085312448 cites W2935172990 @default.
- W3085312448 cites W2952633727 @default.
- W3085312448 cites W34264966 @default.
- W3085312448 doi "https://doi.org/10.18632/aging.103641" @default.
- W3085312448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7521524" @default.
- W3085312448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32915773" @default.
- W3085312448 hasPublicationYear "2020" @default.
- W3085312448 type Work @default.
- W3085312448 sameAs 3085312448 @default.
- W3085312448 citedByCount "5" @default.
- W3085312448 countsByYear W30853124482021 @default.
- W3085312448 countsByYear W30853124482022 @default.
- W3085312448 countsByYear W30853124482023 @default.
- W3085312448 crossrefType "journal-article" @default.
- W3085312448 hasAuthorship W3085312448A5000432967 @default.
- W3085312448 hasAuthorship W3085312448A5013734736 @default.
- W3085312448 hasAuthorship W3085312448A5028296024 @default.
- W3085312448 hasAuthorship W3085312448A5042947574 @default.
- W3085312448 hasAuthorship W3085312448A5054459491 @default.
- W3085312448 hasAuthorship W3085312448A5062281323 @default.
- W3085312448 hasAuthorship W3085312448A5080454453 @default.
- W3085312448 hasAuthorship W3085312448A5083418447 @default.
- W3085312448 hasBestOaLocation W30853124481 @default.
- W3085312448 hasConcept C104317684 @default.
- W3085312448 hasConcept C119157956 @default.
- W3085312448 hasConcept C123765429 @default.
- W3085312448 hasConcept C134018914 @default.
- W3085312448 hasConcept C16685009 @default.
- W3085312448 hasConcept C2777394357 @default.
- W3085312448 hasConcept C2777595374 @default.
- W3085312448 hasConcept C2780561631 @default.