FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085365057> ?p ?o ?g. }

• W3085365057 endingPage "66" @default.
• W3085365057 startingPage "55" @default.
• W3085365057 abstract "Abstract COVID-19 rapidly emerged as a crippling public health crisis in the last few months, which has presented a series health risk. Understanding of the immune response and biomarker analysis is needed to progress toward understanding disease pathology and developing improved treatment options. The goal of this study is to identify pathogenic factors that are linked to disease severity and patient characteristics. Patients with COVID-19 who were hospitalized from March 17 to June 5, 2020 were analyzed for clinical features of disease and soluble plasma cytokines in association with disease severity and sex. Data from COVID-19 patients with acute illness were examined along with an age- and gender-matched control cohort. We identified a group of 16 soluble factors that were found to be increased in COVID-19 patients compared to controls, whereas 2 factors were decreased. In addition to inflammatory cytokines, we found significant increases in factors known to mediate vasculitis and vascular remodeling (PDGF-AA, PDGF-AB-BB, soluble CD40L (sCD40L), FGF, and IP10). Four factors such as platelet-derived growth factors, fibroblast growth factor-2, and IFN-γ-inducible protein 10 were strongly associated with severe disease and ICU admission. Th2-related factors (IL-4 and IL-13) were increased with IL-4 and sCD40L present at increased levels in males compared with females. Our analysis revealed networking clusters of cytokines and growth factors, including previously unknown roles of vascular and stromal remodeling, activation of the innate immunity, as well activation of type 2 immune responses in the immunopathogenesis of COVID-19. These data highlight biomarker associations with disease severity and sex in COVID-19 patients." @default.
• W3085365057 created "2020-09-21" @default.
• W3085365057 creator A5022402337 @default.
• W3085365057 creator A5029464451 @default.
• W3085365057 creator A5051121804 @default.
• W3085365057 creator A5054832337 @default.
• W3085365057 creator A5070492897 @default.
• W3085365057 creator A5091378889 @default.
• W3085365057 date "2020-09-15" @default.
• W3085365057 modified "2023-10-02" @default.
• W3085365057 title "Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex" @default.
• W3085365057 cites W135839998 @default.
• W3085365057 cites W1485587526 @default.
• W3085365057 cites W1561501622 @default.
• W3085365057 cites W1809561724 @default.
• W3085365057 cites W2013322971 @default.
• W3085365057 cites W2013464021 @default.
• W3085365057 cites W2016040720 @default.
• W3085365057 cites W2019446509 @default.
• W3085365057 cites W2024921016 @default.
• W3085365057 cites W2029393791 @default.
• W3085365057 cites W2065484205 @default.
• W3085365057 cites W2096606428 @default.
• W3085365057 cites W2098763821 @default.
• W3085365057 cites W2103167703 @default.
• W3085365057 cites W2117775981 @default.
• W3085365057 cites W2125212147 @default.
• W3085365057 cites W2134061616 @default.
• W3085365057 cites W2148340635 @default.
• W3085365057 cites W2158939655 @default.
• W3085365057 cites W2749038607 @default.
• W3085365057 cites W2968532079 @default.
• W3085365057 cites W3001118548 @default.
• W3085365057 cites W3007273493 @default.
• W3085365057 cites W3007866917 @default.
• W3085365057 cites W3008827533 @default.
• W3085365057 cites W3011559677 @default.
• W3085365057 cites W3012259277 @default.
• W3085365057 cites W3012721127 @default.
• W3085365057 cites W3013008917 @default.
• W3085365057 cites W3013326786 @default.
• W3085365057 cites W3014050022 @default.
• W3085365057 cites W3014586511 @default.
• W3085365057 cites W3015289726 @default.
• W3085365057 cites W3015492319 @default.
• W3085365057 cites W3016535995 @default.
• W3085365057 cites W3020646040 @default.
• W3085365057 cites W3021024241 @default.
• W3085365057 cites W3021841162 @default.
• W3085365057 cites W3023365704 @default.
• W3085365057 cites W3023750295 @default.
• W3085365057 cites W3024411435 @default.
• W3085365057 cites W3024521558 @default.
• W3085365057 cites W3025256562 @default.
• W3085365057 cites W3030918908 @default.
• W3085365057 cites W3034512127 @default.
• W3085365057 cites W3034529698 @default.
• W3085365057 doi "https://doi.org/10.1002/jlb.3cova0820-410rrr" @default.
• W3085365057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7902354" @default.
• W3085365057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32930456" @default.
• W3085365057 hasPublicationYear "2020" @default.
• W3085365057 type Work @default.
• W3085365057 sameAs 3085365057 @default.
• W3085365057 citedByCount "78" @default.
• W3085365057 countsByYear W30853650572020 @default.
• W3085365057 countsByYear W30853650572021 @default.
• W3085365057 countsByYear W30853650572022 @default.
• W3085365057 countsByYear W30853650572023 @default.
• W3085365057 crossrefType "journal-article" @default.
• W3085365057 hasAuthorship W3085365057A5022402337 @default.
• W3085365057 hasAuthorship W3085365057A5029464451 @default.
• W3085365057 hasAuthorship W3085365057A5051121804 @default.
• W3085365057 hasAuthorship W3085365057A5054832337 @default.
• W3085365057 hasAuthorship W3085365057A5070492897 @default.
• W3085365057 hasAuthorship W3085365057A5091378889 @default.
• W3085365057 hasBestOaLocation W30853650571 @default.
• W3085365057 hasConcept C126322002 @default.
• W3085365057 hasConcept C136449434 @default.
• W3085365057 hasConcept C203014093 @default.
• W3085365057 hasConcept C2778690821 @default.
• W3085365057 hasConcept C2779134260 @default.
• W3085365057 hasConcept C2780194698 @default.
• W3085365057 hasConcept C2781197716 @default.
• W3085365057 hasConcept C3018697912 @default.
• W3085365057 hasConcept C55493867 @default.
• W3085365057 hasConcept C71924100 @default.
• W3085365057 hasConcept C86803240 @default.
• W3085365057 hasConcept C8891405 @default.
• W3085365057 hasConcept C89560881 @default.
• W3085365057 hasConceptScore W3085365057C126322002 @default.
• W3085365057 hasConceptScore W3085365057C136449434 @default.
• W3085365057 hasConceptScore W3085365057C203014093 @default.
• W3085365057 hasConceptScore W3085365057C2778690821 @default.
• W3085365057 hasConceptScore W3085365057C2779134260 @default.
• W3085365057 hasConceptScore W3085365057C2780194698 @default.
• W3085365057 hasConceptScore W3085365057C2781197716 @default.
• W3085365057 hasConceptScore W3085365057C3018697912 @default.
• W3085365057 hasConceptScore W3085365057C55493867 @default.

• next