FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085367181> ?p ?o ?g. }

• W3085367181 endingPage "1649" @default.
• W3085367181 startingPage "1639" @default.
• W3085367181 abstract "Abstract Background Respiratory syncytial virus (RSV) is the leading cause of severe respiratory disease in infants. The causes and correlates of severe illness in the majority of infants are poorly defined. Methods We recruited a cohort of RSV-infected infants and simultaneously assayed the molecular status of their airways and the presence of airway microbiota. We used rigorous statistical approaches to identify gene expression patterns associated with disease severity and microbiota composition, separately and in combination. Results We measured comprehensive airway gene expression patterns in 106 infants with primary RSV infection. We identified an airway gene expression signature of severe illness dominated by excessive chemokine expression. We also found an association between Haemophilus influenzae, disease severity, and airway lymphocyte accumulation. Exploring the time of onset of clinical symptoms revealed acute activation of interferon signaling following RSV infection in infants with mild or moderate illness, which was absent in subjects with severe illness. Conclusions Our data reveal that airway gene expression patterns distinguish mild/moderate from severe illness. Furthermore, our data identify biomarkers that may be therapeutic targets or useful for measuring efficacy of intervention responses." @default.
• W3085367181 created "2020-09-21" @default.
• W3085367181 creator A5001112181 @default.
• W3085367181 creator A5005429562 @default.
• W3085367181 creator A5029484872 @default.
• W3085367181 creator A5033294943 @default.
• W3085367181 creator A5039338085 @default.
• W3085367181 creator A5042151067 @default.
• W3085367181 creator A5061777286 @default.
• W3085367181 creator A5071721061 @default.
• W3085367181 creator A5073591651 @default.
• W3085367181 creator A5079409186 @default.
• W3085367181 creator A5080088251 @default.
• W3085367181 creator A5081842855 @default.
• W3085367181 creator A5082651048 @default.
• W3085367181 creator A5089284552 @default.
• W3085367181 creator A5023975442 @default.
• W3085367181 date "2020-09-14" @default.
• W3085367181 modified "2023-10-13" @default.
• W3085367181 title "Airway Gene Expression Correlates of Respiratory Syncytial Virus Disease Severity and Microbiome Composition in Infants" @default.
• W3085367181 cites W156352715 @default.
• W3085367181 cites W1818149717 @default.
• W3085367181 cites W1986189079 @default.
• W3085367181 cites W2005370302 @default.
• W3085367181 cites W2025391611 @default.
• W3085367181 cites W2026006003 @default.
• W3085367181 cites W2071660631 @default.
• W3085367181 cites W2072970694 @default.
• W3085367181 cites W2078706891 @default.
• W3085367181 cites W2099280130 @default.
• W3085367181 cites W2100589529 @default.
• W3085367181 cites W2101114010 @default.
• W3085367181 cites W2106701493 @default.
• W3085367181 cites W2107665951 @default.
• W3085367181 cites W2109831018 @default.
• W3085367181 cites W2124649657 @default.
• W3085367181 cites W2134410087 @default.
• W3085367181 cites W2142794642 @default.
• W3085367181 cites W2146512944 @default.
• W3085367181 cites W2146536283 @default.
• W3085367181 cites W2162143298 @default.
• W3085367181 cites W2168907148 @default.
• W3085367181 cites W2177348612 @default.
• W3085367181 cites W2265221712 @default.
• W3085367181 cites W2318832328 @default.
• W3085367181 cites W2335562578 @default.
• W3085367181 cites W2346069395 @default.
• W3085367181 cites W2523035172 @default.
• W3085367181 cites W2561960704 @default.
• W3085367181 cites W2563401243 @default.
• W3085367181 cites W2566587016 @default.
• W3085367181 cites W2586676015 @default.
• W3085367181 cites W2620686538 @default.
• W3085367181 cites W2727509207 @default.
• W3085367181 cites W2744019602 @default.
• W3085367181 cites W2745986215 @default.
• W3085367181 cites W2757615417 @default.
• W3085367181 cites W2758001830 @default.
• W3085367181 cites W2771319431 @default.
• W3085367181 cites W2773981927 @default.
• W3085367181 cites W2792552406 @default.
• W3085367181 cites W2807079831 @default.
• W3085367181 cites W2896802097 @default.
• W3085367181 cites W2897215926 @default.
• W3085367181 cites W2920725640 @default.
• W3085367181 cites W2951047095 @default.
• W3085367181 cites W3085268924 @default.
• W3085367181 cites W3099018540 @default.
• W3085367181 doi "https://doi.org/10.1093/infdis/jiaa576" @default.
• W3085367181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8136980" @default.
• W3085367181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32926149" @default.
• W3085367181 hasPublicationYear "2020" @default.
• W3085367181 type Work @default.
• W3085367181 sameAs 3085367181 @default.
• W3085367181 citedByCount "16" @default.
• W3085367181 countsByYear W30853671812020 @default.
• W3085367181 countsByYear W30853671812021 @default.
• W3085367181 countsByYear W30853671812022 @default.
• W3085367181 countsByYear W30853671812023 @default.
• W3085367181 crossrefType "journal-article" @default.
• W3085367181 hasAuthorship W3085367181A5001112181 @default.
• W3085367181 hasAuthorship W3085367181A5005429562 @default.
• W3085367181 hasAuthorship W3085367181A5023975442 @default.
• W3085367181 hasAuthorship W3085367181A5029484872 @default.
• W3085367181 hasAuthorship W3085367181A5033294943 @default.
• W3085367181 hasAuthorship W3085367181A5039338085 @default.
• W3085367181 hasAuthorship W3085367181A5042151067 @default.
• W3085367181 hasAuthorship W3085367181A5061777286 @default.
• W3085367181 hasAuthorship W3085367181A5071721061 @default.
• W3085367181 hasAuthorship W3085367181A5073591651 @default.
• W3085367181 hasAuthorship W3085367181A5079409186 @default.
• W3085367181 hasAuthorship W3085367181A5080088251 @default.
• W3085367181 hasAuthorship W3085367181A5081842855 @default.
• W3085367181 hasAuthorship W3085367181A5082651048 @default.
• W3085367181 hasAuthorship W3085367181A5089284552 @default.
• W3085367181 hasBestOaLocation W30853671812 @default.
• W3085367181 hasConcept C105922876 @default.
• W3085367181 hasConcept C126322002 @default.

• next