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• W3085419075 abstract "Precise patterning within the 3-dimensional context of tissues, organs and embryos implies that cells can sense their relative position. During preimplantation development, outside and inside cells rely on apicobasal polarity and the Hippo pathway to choose their fate. Despite recent findings suggesting that mechanosensing may be central to this process, the relationship between blastomere geometry (i.e. shape and position) and the Hippo pathway effector YAP remains unknown. We used a highly quantitative approach to analyse information on the geometry and YAP localisation of individual blastomeres of mouse and human embryos. We identify proportion of exposed cell surface area as most closely correlating with nuclear localisation of YAP. To test this relationship, we developed several hydrogel-based approaches to alter blastomere geometry in cultured embryos. Unbiased clustering analyses of blastomeres from such embryos reveal that this relationship emerges during compaction. Our results therefore pinpoint when during early embryogenesis cells acquire the ability to sense changes in geometry and provide a new framework for how cells might integrate signals from different membrane domains to assess their relative position within the embryo." @default.
• W3085419075 created "2020-09-21" @default.
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• W3085419075 date "2020-01-01" @default.
• W3085419075 modified "2023-10-01" @default.
• W3085419075 title "Establishment of a relationship between blastomere geometry and YAP localisation during compaction" @default.
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• W3085419075 doi "https://doi.org/10.1242/dev.189449" @default.
• W3085419075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7561472" @default.
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