FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085442632> ?p ?o ?g. }

• W3085442632 endingPage "61" @default.
• W3085442632 startingPage "55" @default.
• W3085442632 abstract "Abaloparatide increased ultradistal radius bone mineral density (BMD) in the Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE) trial. Over the subsequent 24 months in ACTIVExtend, ultradistal radius BMD gains were maintained with alendronate. Conversely, 1/3 radius BMD remained stable during ALN treatment in ACTIVExtend after decreasing during ACTIVE. Abaloparatide (ABL) increased femoral neck, total hip, and lumbar spine bone mineral density (BMD) in postmenopausal women with osteoporosis and decreased the risk of vertebral and nonvertebral fractures in ACTIVE. Effects on fracture risk and BMD were maintained subsequently with alendronate (ALN) in ACTIVExtend. In a prespecified subanalysis of ACTIVE, ABL also increased BMD at the ultradistal radius. Our objective was to determine the efficacy of ABL followed by ALN vs placebo (PBO) followed by ALN on forearm BMD and fracture risk over 43 months in ACTIVExtend. Ultradistal and 1/3 radius BMD (ACTIVE baseline to month 43) were measured (ABL/ALN, n = 213; PBO/ALN, n = 233). Wrist fracture rates were estimated for the ACTIVExtend intent-to-treat population (ABL/ALN, n = 558; PBO/ALN, n = 581) by Kaplan-Meier (KM) method. At cumulative month 25, mean increase from ACTIVE baseline in ultradistal radius BMD was 1.1% (standard error, 0.49%) with ABL/ALN vs − 0.8% (0.43%) with PBO/ALN (P < 0.01). BMD increases with ABL were maintained with ALN through month 43 in ACTIVExtend. BMD decreases at the 1/3 radius in ACTIVE (similar with ABL and PBO) were maintained through 24 months of ALN treatment in ACTIVExtend. Wrist fractures over 43 months occurred in 15 women with ABL/ALN (KM estimate, 2.8%) and 20 with PBO/ALN (KM estimate, 3.6%) (HR = 0.77, 95% CI 0.39, 1.50; P = not significant). Ultradistal radius BMD gains following treatment with ABL in ACTIVE were maintained over 24 months of ALN treatment in ACTIVExtend. Conversely, 1/3 radius BMD remained stable during ALN treatment in ACTIVExtend after decreasing during ACTIVE. ClinicalTrials.gov : NCT01657162 submitted July 31, 2012" @default.
• W3085442632 created "2020-09-21" @default.
• W3085442632 creator A5010323319 @default.
• W3085442632 creator A5026072640 @default.
• W3085442632 creator A5026116892 @default.
• W3085442632 creator A5030297788 @default.
• W3085442632 creator A5042999308 @default.
• W3085442632 creator A5044829086 @default.
• W3085442632 creator A5075226333 @default.
• W3085442632 creator A5090665248 @default.
• W3085442632 date "2020-09-15" @default.
• W3085442632 modified "2023-09-23" @default.
• W3085442632 title "Forearm bone mineral density and fracture incidence in postmenopausal women with osteoporosis: results from the ACTIVExtend phase 3 trial" @default.
• W3085442632 cites W1916938161 @default.
• W3085442632 cites W2018990477 @default.
• W3085442632 cites W2056819796 @default.
• W3085442632 cites W2059670446 @default.
• W3085442632 cites W2094819865 @default.
• W3085442632 cites W2107091912 @default.
• W3085442632 cites W2159816244 @default.
• W3085442632 cites W2176994106 @default.
• W3085442632 cites W2466803346 @default.
• W3085442632 cites W2516614130 @default.
• W3085442632 cites W2759210399 @default.
• W3085442632 cites W2775903390 @default.
• W3085442632 cites W2803459905 @default.
• W3085442632 cites W2912416377 @default.
• W3085442632 cites W2921343230 @default.
• W3085442632 cites W2923127906 @default.
• W3085442632 doi "https://doi.org/10.1007/s00198-020-05555-1" @default.
• W3085442632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7755646" @default.
• W3085442632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32935170" @default.
• W3085442632 hasPublicationYear "2020" @default.
• W3085442632 type Work @default.
• W3085442632 sameAs 3085442632 @default.
• W3085442632 citedByCount "2" @default.
• W3085442632 countsByYear W30854426322021 @default.
• W3085442632 countsByYear W30854426322023 @default.
• W3085442632 crossrefType "journal-article" @default.
• W3085442632 hasAuthorship W3085442632A5010323319 @default.
• W3085442632 hasAuthorship W3085442632A5026072640 @default.
• W3085442632 hasAuthorship W3085442632A5026116892 @default.
• W3085442632 hasAuthorship W3085442632A5030297788 @default.
• W3085442632 hasAuthorship W3085442632A5042999308 @default.
• W3085442632 hasAuthorship W3085442632A5044829086 @default.
• W3085442632 hasAuthorship W3085442632A5075226333 @default.
• W3085442632 hasAuthorship W3085442632A5090665248 @default.
• W3085442632 hasBestOaLocation W30854426321 @default.
• W3085442632 hasConcept C120665830 @default.
• W3085442632 hasConcept C121332964 @default.
• W3085442632 hasConcept C126322002 @default.
• W3085442632 hasConcept C141071460 @default.
• W3085442632 hasConcept C1862650 @default.
• W3085442632 hasConcept C198451711 @default.
• W3085442632 hasConcept C199343813 @default.
• W3085442632 hasConcept C2776541429 @default.
• W3085442632 hasConcept C2776886416 @default.
• W3085442632 hasConcept C2779329777 @default.
• W3085442632 hasConcept C2780214079 @default.
• W3085442632 hasConcept C2911223091 @default.
• W3085442632 hasConcept C3018603563 @default.
• W3085442632 hasConcept C61511704 @default.
• W3085442632 hasConcept C68312169 @default.
• W3085442632 hasConcept C71924100 @default.
• W3085442632 hasConceptScore W3085442632C120665830 @default.
• W3085442632 hasConceptScore W3085442632C121332964 @default.
• W3085442632 hasConceptScore W3085442632C126322002 @default.
• W3085442632 hasConceptScore W3085442632C141071460 @default.
• W3085442632 hasConceptScore W3085442632C1862650 @default.
• W3085442632 hasConceptScore W3085442632C198451711 @default.
• W3085442632 hasConceptScore W3085442632C199343813 @default.
• W3085442632 hasConceptScore W3085442632C2776541429 @default.
• W3085442632 hasConceptScore W3085442632C2776886416 @default.
• W3085442632 hasConceptScore W3085442632C2779329777 @default.
• W3085442632 hasConceptScore W3085442632C2780214079 @default.
• W3085442632 hasConceptScore W3085442632C2911223091 @default.
• W3085442632 hasConceptScore W3085442632C3018603563 @default.
• W3085442632 hasConceptScore W3085442632C61511704 @default.
• W3085442632 hasConceptScore W3085442632C68312169 @default.
• W3085442632 hasConceptScore W3085442632C71924100 @default.
• W3085442632 hasIssue "1" @default.
• W3085442632 hasLocation W30854426321 @default.
• W3085442632 hasLocation W30854426322 @default.
• W3085442632 hasOpenAccess W3085442632 @default.
• W3085442632 hasPrimaryLocation W30854426321 @default.
• W3085442632 hasRelatedWork W126705310 @default.
• W3085442632 hasRelatedWork W1957232404 @default.
• W3085442632 hasRelatedWork W2012040792 @default.
• W3085442632 hasRelatedWork W2054899289 @default.
• W3085442632 hasRelatedWork W2076601099 @default.
• W3085442632 hasRelatedWork W2409139096 @default.
• W3085442632 hasRelatedWork W2923127906 @default.
• W3085442632 hasRelatedWork W3013575109 @default.
• W3085442632 hasRelatedWork W3085442632 @default.
• W3085442632 hasRelatedWork W4283010444 @default.
• W3085442632 hasVolume "32" @default.
• W3085442632 isParatext "false" @default.
• W3085442632 isRetracted "false" @default.

• next