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- W3085444800 endingPage "2330" @default.
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- W3085444800 abstract "Abstract SARS‐CoV‐2, the causing agent of the ongoing COVID‐19 pandemic, is a beta‐coronavirus which has 80% genetic homology with SARS‐CoV, but displays increased virulence and transmissibility. Initially, SARS‐CoV‐2 was considered a respiratory virus generally causing a mild disease, only severe and fatal in the elderly and individuals with underlying conditions. Severe illnesses and fatalities were attributed to a cytokine storm, an excessive response from the host immune system. However, with the number of infections over 10 millions and still soaring, the insidious and stealthy nature of the virus has emerged, as it causes a vast array of diverse unexpected symptoms among infected individuals, including the young and healthy. It has become evident that besides infecting the respiratory tract, SARS‐CoV‐2 can affect many organs, possibly through the infection of the endothelium. This review presents an overview of our learning curve with the novel virus emergence, transmission, pathology, biological properties and host‐interactions. It also briefly describes remedial measures taken until an effective vaccine is available, that is non‐pharmaceutical interventions to reduce the viral spread and the repurposing of existing drugs, approved or in development for other conditions to eliminate the virus or mitigate the cytokine storm." @default.
- W3085444800 created "2020-09-21" @default.
- W3085444800 creator A5036278471 @default.
- W3085444800 creator A5038072696 @default.
- W3085444800 creator A5048849645 @default.
- W3085444800 creator A5063524519 @default.
- W3085444800 creator A5065802143 @default.
- W3085444800 date "2020-09-12" @default.
- W3085444800 modified "2023-10-17" @default.
- W3085444800 title "<scp>SARS‐CoV</scp>‐2 multifaceted interaction with human host. Part I: What we have learnt and done so far, and the still unknown realities" @default.
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