Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085448923> ?p ?o ?g. }
- W3085448923 endingPage "e0238524" @default.
- W3085448923 startingPage "e0238524" @default.
- W3085448923 abstract "Background Markers of lung inflammation measured directly in expectorated sputum have the potential of improving the timing of antibiotic treatment in cystic fibrosis (CF). L-Lactate might be a marker of inflammation, as it is produced from glucose by polymorphonuclear neutrophils (PMNs) in CF lungs. We aimed to investigate changes in and associations between PMNs, glucose and L-lactate in sputum during antibiotic treatment. In addition, the effect of hemoglobin A1c and plasma glucose on these biomarkers were investigated. Methods We sampled non-induced sputum at day 0, 7, 14 and 42 in 27 chronically infected CF patients electively treated with 14 days of intravenous antibiotic. To analyze sputum samples, we used flowcytometry to count PMNs and colorimetric assays to estimate lactate and glucose. Results No changes in levels of PMNs, glucose and lactate were detected in sputum during the antibiotic treatment. Sputum PMNs were positively associated with both glucose (log coefficient = 0.20, p = 0.01) and L-lactate (log coefficient = 0.34, p<0.001). In multivariate analyses, hemoglobin A1c was negatively associated with sputum PMNs (log coefficient = -1.68, p<0.001) and plasma glucose was negatively associated with sputum glucose (log coefficient = -0.09, p = 0.02). Conclusions In CF sputum PMNs, glucose and lactate were unchanged during elective antibiotic treatment. However, sputum PMNs were associated with both sputum glucose and sputum lactate. Surprisingly, hyperglycemia seemed to be associated with less PMNs infiltration and less glucose in CF sputum." @default.
- W3085448923 created "2020-09-21" @default.
- W3085448923 creator A5000216468 @default.
- W3085448923 creator A5008992746 @default.
- W3085448923 creator A5012930045 @default.
- W3085448923 creator A5027340715 @default.
- W3085448923 creator A5040137110 @default.
- W3085448923 creator A5060674788 @default.
- W3085448923 creator A5074555605 @default.
- W3085448923 creator A5087676335 @default.
- W3085448923 date "2020-09-11" @default.
- W3085448923 modified "2023-09-27" @default.
- W3085448923 title "Neutrophil count in sputum is associated with increased sputum glucose and sputum L-lactate in cystic fibrosis" @default.
- W3085448923 cites W1971512067 @default.
- W3085448923 cites W1980017808 @default.
- W3085448923 cites W1989056520 @default.
- W3085448923 cites W1990846908 @default.
- W3085448923 cites W2000707638 @default.
- W3085448923 cites W2012915499 @default.
- W3085448923 cites W2014127296 @default.
- W3085448923 cites W2015478670 @default.
- W3085448923 cites W2034964508 @default.
- W3085448923 cites W2037830557 @default.
- W3085448923 cites W2049025796 @default.
- W3085448923 cites W2097072748 @default.
- W3085448923 cites W2097389043 @default.
- W3085448923 cites W2099449365 @default.
- W3085448923 cites W2121890764 @default.
- W3085448923 cites W2130593861 @default.
- W3085448923 cites W2136086207 @default.
- W3085448923 cites W2151593963 @default.
- W3085448923 cites W2152169346 @default.
- W3085448923 cites W2152321550 @default.
- W3085448923 cites W2155069031 @default.
- W3085448923 cites W2157195518 @default.
- W3085448923 cites W2185801551 @default.
- W3085448923 cites W2257989502 @default.
- W3085448923 cites W2559479328 @default.
- W3085448923 cites W2592982491 @default.
- W3085448923 cites W2768714162 @default.
- W3085448923 cites W2768861249 @default.
- W3085448923 cites W2781950597 @default.
- W3085448923 cites W2909985299 @default.
- W3085448923 cites W2971126321 @default.
- W3085448923 cites W4244472847 @default.
- W3085448923 cites W4252523298 @default.
- W3085448923 doi "https://doi.org/10.1371/journal.pone.0238524" @default.
- W3085448923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7485830" @default.
- W3085448923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32915806" @default.
- W3085448923 hasPublicationYear "2020" @default.
- W3085448923 type Work @default.
- W3085448923 sameAs 3085448923 @default.
- W3085448923 citedByCount "5" @default.
- W3085448923 countsByYear W30854489232021 @default.
- W3085448923 countsByYear W30854489232022 @default.
- W3085448923 countsByYear W30854489232023 @default.
- W3085448923 crossrefType "journal-article" @default.
- W3085448923 hasAuthorship W3085448923A5000216468 @default.
- W3085448923 hasAuthorship W3085448923A5008992746 @default.
- W3085448923 hasAuthorship W3085448923A5012930045 @default.
- W3085448923 hasAuthorship W3085448923A5027340715 @default.
- W3085448923 hasAuthorship W3085448923A5040137110 @default.
- W3085448923 hasAuthorship W3085448923A5060674788 @default.
- W3085448923 hasAuthorship W3085448923A5074555605 @default.
- W3085448923 hasAuthorship W3085448923A5087676335 @default.
- W3085448923 hasBestOaLocation W30854489231 @default.
- W3085448923 hasConcept C126322002 @default.
- W3085448923 hasConcept C142724271 @default.
- W3085448923 hasConcept C203014093 @default.
- W3085448923 hasConcept C2776301714 @default.
- W3085448923 hasConcept C2776938444 @default.
- W3085448923 hasConcept C2781069245 @default.
- W3085448923 hasConcept C501593827 @default.
- W3085448923 hasConcept C71924100 @default.
- W3085448923 hasConcept C86803240 @default.
- W3085448923 hasConcept C89423630 @default.
- W3085448923 hasConcept C90924648 @default.
- W3085448923 hasConceptScore W3085448923C126322002 @default.
- W3085448923 hasConceptScore W3085448923C142724271 @default.
- W3085448923 hasConceptScore W3085448923C203014093 @default.
- W3085448923 hasConceptScore W3085448923C2776301714 @default.
- W3085448923 hasConceptScore W3085448923C2776938444 @default.
- W3085448923 hasConceptScore W3085448923C2781069245 @default.
- W3085448923 hasConceptScore W3085448923C501593827 @default.
- W3085448923 hasConceptScore W3085448923C71924100 @default.
- W3085448923 hasConceptScore W3085448923C86803240 @default.
- W3085448923 hasConceptScore W3085448923C89423630 @default.
- W3085448923 hasConceptScore W3085448923C90924648 @default.
- W3085448923 hasIssue "9" @default.
- W3085448923 hasLocation W30854489231 @default.
- W3085448923 hasLocation W30854489232 @default.
- W3085448923 hasLocation W30854489233 @default.
- W3085448923 hasLocation W30854489234 @default.
- W3085448923 hasOpenAccess W3085448923 @default.
- W3085448923 hasPrimaryLocation W30854489231 @default.
- W3085448923 hasRelatedWork W1894053594 @default.
- W3085448923 hasRelatedWork W2055347946 @default.
- W3085448923 hasRelatedWork W2064068126 @default.