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• W3085455067 startingPage "100141" @default.
• W3085455067 abstract "Disruption of neurodevelopmental trajectories can alter brain circuitry and increase the risk of psychopathology later in life. While preclinical studies have demonstrated that the immune system and cytokines influence neurodevelopment, whether immune activity and in particular which cytokines at birth are associated with psychopathology remains poorly explored in children. We used data and biological samples from 869 mother-child pairs participating in the French mother-child cohort EDEN. As proxies for immune activity at birth, we measured the levels of 27 cytokines in umbilical cord blood sera (CBS). We then explored the association between CBS cytokine levels and five psychopathological dimensions assessed in 5-year-old children using the Strengths and Difficulties Questionnaire (SDQ). Five cytokines were positively associated with psychopathology: C-X-C motif chemokine Ligand (CXCL)10, interleukin (IL)-10 and IL-12p40 with emotional symptoms, C–C motif chemokine Ligand (CCL)11 with conduct problems, and CCL11, and IL-17A with peer relationships problems. In contrast, seven cytokines were negatively associated with psychopathology: IL-7, IL-15 and Tumor Necrosis Factor (TNF)-β with emotional symptoms, CCL4 and IL-6 with conduct problems, CCL26 and IL-15 with peer relationships problems, and CCL26, IL-7, IL-15, and TNF-α with abnormal prosocial behavior. Without implying causation, these associations support the notion that cytokines influence neurodevelopment in humans and the risk of psychopathology later in life." @default.
• W3085455067 created "2020-09-21" @default.
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• W3085455067 date "2020-10-01" @default.
• W3085455067 modified "2023-10-11" @default.
• W3085455067 title "Immune activity at birth and later psychopathology in childhood" @default.
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• W3085455067 doi "https://doi.org/10.1016/j.bbih.2020.100141" @default.
• W3085455067 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8474670" @default.
• W3085455067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34589885" @default.
• W3085455067 hasPublicationYear "2020" @default.
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