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• W3085458823 abstract "Abstract Previously, we determined a cryo-EM structure of Saccharomyces cerevisiae 90S preribosome obtained after depletion of the RNA helicase Mtr4 at 4.5 Å resolution (Sun et al., 2017). The 90S preribosome is an early assembly intermediate of small ribosomal subunit. Here, the structure was improved to 3.4 Å resolution and reveals many previously unresolved structures and interactions, in particular around the central domain of 18S rRNA. The central domain adopts a closed conformation in our structure, in contrast to an open conformation in another high-resolution structure of S. cerevisiae 90S. The new model of 90S would serve as a better reference for investigation of the assembly mechanism of small ribosomal subunit." @default.
• W3085458823 created "2020-09-21" @default.
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• W3085458823 date "2020-09-16" @default.
• W3085458823 modified "2023-09-26" @default.
• W3085458823 title "Cryo-EM structure of yeast 90S preribosome at 3.4 Å resolution" @default.
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• W3085458823 doi "https://doi.org/10.1101/2020.09.16.299644" @default.
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