Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085482054> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3085482054 abstract "Abstract The Starlet high-resolution manometry (HRM) system is currently used in Japan. HRM provides integrated relaxation pressure (IRP) of which value represents adequacy of lower esophageal sphincter (LES) relaxation. The upper limit of normal IRP for the Starlet was proposed as 26 mmHg using healthy subjects. However, few studies have addressed whether this cutoff may well-distinguish patients diagnosed with/without achalasia. We propose the optimal cutoff of IRP for detecting achalasia using the Starlet. Methods Patients who underwent HRM test using the Starlet system at our institution between July 2018 and December 2019 were included. Of these, we excluded patients who had a history of achalasia surgery and/or endoscopic intervention, or whose HRM testing of poor quality. Achalasia was diagnosed if impaired esophageal emptying was evident based on timed barium esophagogram, upper endoscopy, and/or computed tomography. The optimal cutoff value of IRP was estimated using the receiver operating characteristic curve analysis. We further investigate difference in IRP values between achalasia subtypes to identify characteristics of patients who are more likely to be misdiagnosed. Results In total, 145 patients met study criteria. The mean age in our cohort was 52.5 ± 15.5 years, 89 patients (61.4%) were men. Of these, 42 patients (29.0%) were diagnosed with achalasia. In achalasia patients, IRP values extended to a wide-range from minimal 18.7 to maximal 63.9 mmHg. The optimal cutoff value of IRP was 24.7 mmHg with sensitivity 90.5% and specificity 90.3% (AUC 0.96 [95% CI; 0.92¬ to 0.99]). Patients with achalasia type I based on Chicago classification were most likely to have IRP value below the threshold of 25 mmHg (4/19 patients [21.1%]). Conclusion The optimal cutoff value of IRP to distinguish achalasia was ≥25 mmHg using the Starlet HRM system. This value was nearly close to the upper limit of normal IRP value of 26 mmHg in healthy volunteers. Achalasia type I was more likely to have normal IRP value indicating that comprehensive foregut assessment (eg, timed barium esophagogram, upper endoscopy, and computed tomography) is still valuable for management of achalasia." @default.
- W3085482054 created "2020-09-21" @default.
- W3085482054 creator A5018378641 @default.
- W3085482054 creator A5023489557 @default.
- W3085482054 creator A5037165615 @default.
- W3085482054 creator A5050707431 @default.
- W3085482054 creator A5058151593 @default.
- W3085482054 creator A5059577855 @default.
- W3085482054 creator A5060385975 @default.
- W3085482054 creator A5069240620 @default.
- W3085482054 creator A5070603339 @default.
- W3085482054 creator A5077284182 @default.
- W3085482054 date "2020-09-01" @default.
- W3085482054 modified "2023-09-27" @default.
- W3085482054 title "339 OPTIMAL CUTOFF VALUE OF INTEGRATED LOWER ESOPHAGEAL SPHINCTER RELAXATION PRESSURE FOR ACHALASIA USING STARLET HIGH-RESOLUTION MANOMETRY SYSTEM" @default.
- W3085482054 doi "https://doi.org/10.1093/dote/doaa087.75" @default.
- W3085482054 hasPublicationYear "2020" @default.
- W3085482054 type Work @default.
- W3085482054 sameAs 3085482054 @default.
- W3085482054 citedByCount "0" @default.
- W3085482054 crossrefType "journal-article" @default.
- W3085482054 hasAuthorship W3085482054A5018378641 @default.
- W3085482054 hasAuthorship W3085482054A5023489557 @default.
- W3085482054 hasAuthorship W3085482054A5037165615 @default.
- W3085482054 hasAuthorship W3085482054A5050707431 @default.
- W3085482054 hasAuthorship W3085482054A5058151593 @default.
- W3085482054 hasAuthorship W3085482054A5059577855 @default.
- W3085482054 hasAuthorship W3085482054A5060385975 @default.
- W3085482054 hasAuthorship W3085482054A5069240620 @default.
- W3085482054 hasAuthorship W3085482054A5070603339 @default.
- W3085482054 hasAuthorship W3085482054A5077284182 @default.
- W3085482054 hasConcept C121332964 @default.
- W3085482054 hasConcept C126322002 @default.
- W3085482054 hasConcept C141071460 @default.
- W3085482054 hasConcept C2777819096 @default.
- W3085482054 hasConcept C2778217198 @default.
- W3085482054 hasConcept C2778510232 @default.
- W3085482054 hasConcept C2779134260 @default.
- W3085482054 hasConcept C2779958274 @default.
- W3085482054 hasConcept C3018799001 @default.
- W3085482054 hasConcept C43270747 @default.
- W3085482054 hasConcept C58471807 @default.
- W3085482054 hasConcept C62520636 @default.
- W3085482054 hasConcept C71924100 @default.
- W3085482054 hasConceptScore W3085482054C121332964 @default.
- W3085482054 hasConceptScore W3085482054C126322002 @default.
- W3085482054 hasConceptScore W3085482054C141071460 @default.
- W3085482054 hasConceptScore W3085482054C2777819096 @default.
- W3085482054 hasConceptScore W3085482054C2778217198 @default.
- W3085482054 hasConceptScore W3085482054C2778510232 @default.
- W3085482054 hasConceptScore W3085482054C2779134260 @default.
- W3085482054 hasConceptScore W3085482054C2779958274 @default.
- W3085482054 hasConceptScore W3085482054C3018799001 @default.
- W3085482054 hasConceptScore W3085482054C43270747 @default.
- W3085482054 hasConceptScore W3085482054C58471807 @default.
- W3085482054 hasConceptScore W3085482054C62520636 @default.
- W3085482054 hasConceptScore W3085482054C71924100 @default.
- W3085482054 hasIssue "Supplement_1" @default.
- W3085482054 hasLocation W30854820541 @default.
- W3085482054 hasOpenAccess W3085482054 @default.
- W3085482054 hasPrimaryLocation W30854820541 @default.
- W3085482054 hasRelatedWork W1988986259 @default.
- W3085482054 hasRelatedWork W2027972148 @default.
- W3085482054 hasRelatedWork W2301186490 @default.
- W3085482054 hasRelatedWork W2441239402 @default.
- W3085482054 hasRelatedWork W2969536730 @default.
- W3085482054 hasRelatedWork W2978872221 @default.
- W3085482054 hasRelatedWork W3085482054 @default.
- W3085482054 hasRelatedWork W3118838229 @default.
- W3085482054 hasRelatedWork W4205487527 @default.
- W3085482054 hasRelatedWork W2016500056 @default.
- W3085482054 hasVolume "33" @default.
- W3085482054 isParatext "false" @default.
- W3085482054 isRetracted "false" @default.
- W3085482054 magId "3085482054" @default.
- W3085482054 workType "article" @default.