Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085505087> ?p ?o ?g. }
- W3085505087 endingPage "879" @default.
- W3085505087 startingPage "863" @default.
- W3085505087 abstract "Abstract Prion diseases are fatal and transmissible neurodegenerative disorders caused by the misfolding and aggregation of prion protein. Although recent studies have implicated epigenetic variation in common neurodegenerative disorders, no study has yet explored their role in human prion diseases. Here we profiled genome-wide blood DNA methylation in the most common human prion disease, sporadic Creutzfeldt–Jakob disease (sCJD). Our case–control study ( n = 219), when accounting for differences in cell type composition between individuals, identified 38 probes at genome-wide significance ( p < 1.24 × 10 –7 ). Nine of these sites were taken forward in a replication study, performed in an independent case–control ( n = 186) cohort using pyrosequencing. Sites in or close to FKBP5, AIM2 (2 probes) , UHRF1, KCNAB2 successfully replicated. The blood-based DNA methylation signal was tissue- and disease-specific, in that the replicated probe signals were unchanged in case–control studies using sCJD frontal-cortex ( n = 84), blood samples from patients with Alzheimer’s disease, and from inherited and acquired prion diseases. Machine learning algorithms using blood DNA methylation array profiles accurately distinguished sCJD patients and controls. Finally, we identified sites whose methylation levels associated with prolonged survival in sCJD patients. Altogether, this study has identified a peripheral DNA methylation signature of sCJD with a variety of potential biomarker applications." @default.
- W3085505087 created "2020-09-21" @default.
- W3085505087 creator A5000551479 @default.
- W3085505087 creator A5003222594 @default.
- W3085505087 creator A5018086792 @default.
- W3085505087 creator A5028812792 @default.
- W3085505087 creator A5036075244 @default.
- W3085505087 creator A5038279757 @default.
- W3085505087 creator A5038755491 @default.
- W3085505087 creator A5048692547 @default.
- W3085505087 creator A5054753549 @default.
- W3085505087 creator A5063525602 @default.
- W3085505087 creator A5074924251 @default.
- W3085505087 creator A5083945868 @default.
- W3085505087 creator A5085975040 @default.
- W3085505087 date "2020-09-12" @default.
- W3085505087 modified "2023-10-18" @default.
- W3085505087 title "Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt–Jakob disease" @default.
- W3085505087 cites W1582535061 @default.
- W3085505087 cites W1837901569 @default.
- W3085505087 cites W1979313084 @default.
- W3085505087 cites W1981632978 @default.
- W3085505087 cites W1991244004 @default.
- W3085505087 cites W2009435405 @default.
- W3085505087 cites W2017502278 @default.
- W3085505087 cites W2032265668 @default.
- W3085505087 cites W2037270713 @default.
- W3085505087 cites W2044640439 @default.
- W3085505087 cites W2050685767 @default.
- W3085505087 cites W2054904323 @default.
- W3085505087 cites W2056613924 @default.
- W3085505087 cites W2072142219 @default.
- W3085505087 cites W2072500831 @default.
- W3085505087 cites W2078819049 @default.
- W3085505087 cites W2099144222 @default.
- W3085505087 cites W2104142691 @default.
- W3085505087 cites W2105391259 @default.
- W3085505087 cites W2107665951 @default.
- W3085505087 cites W2112140556 @default.
- W3085505087 cites W2116536643 @default.
- W3085505087 cites W2119924680 @default.
- W3085505087 cites W2127431419 @default.
- W3085505087 cites W2130752875 @default.
- W3085505087 cites W2136895197 @default.
- W3085505087 cites W2137147070 @default.
- W3085505087 cites W2146512944 @default.
- W3085505087 cites W2153947402 @default.
- W3085505087 cites W2158669467 @default.
- W3085505087 cites W2161857374 @default.
- W3085505087 cites W2170324063 @default.
- W3085505087 cites W2254593627 @default.
- W3085505087 cites W2277673148 @default.
- W3085505087 cites W2291905329 @default.
- W3085505087 cites W2306482506 @default.
- W3085505087 cites W2347181525 @default.
- W3085505087 cites W2399843912 @default.
- W3085505087 cites W2549098625 @default.
- W3085505087 cites W2580897959 @default.
- W3085505087 cites W2615166509 @default.
- W3085505087 cites W2751999549 @default.
- W3085505087 cites W2767280000 @default.
- W3085505087 cites W2897187982 @default.
- W3085505087 cites W2903021049 @default.
- W3085505087 cites W2903199137 @default.
- W3085505087 cites W2911388806 @default.
- W3085505087 cites W2913887378 @default.
- W3085505087 cites W2949455383 @default.
- W3085505087 cites W2952497943 @default.
- W3085505087 cites W2952786557 @default.
- W3085505087 cites W2974881324 @default.
- W3085505087 cites W2991469415 @default.
- W3085505087 cites W3007092793 @default.
- W3085505087 cites W3010500731 @default.
- W3085505087 cites W3032860627 @default.
- W3085505087 doi "https://doi.org/10.1007/s00401-020-02224-9" @default.
- W3085505087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7666287" @default.
- W3085505087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32918118" @default.
- W3085505087 hasPublicationYear "2020" @default.
- W3085505087 type Work @default.
- W3085505087 sameAs 3085505087 @default.
- W3085505087 citedByCount "14" @default.
- W3085505087 countsByYear W30855050872021 @default.
- W3085505087 countsByYear W30855050872022 @default.
- W3085505087 countsByYear W30855050872023 @default.
- W3085505087 crossrefType "journal-article" @default.
- W3085505087 hasAuthorship W3085505087A5000551479 @default.
- W3085505087 hasAuthorship W3085505087A5003222594 @default.
- W3085505087 hasAuthorship W3085505087A5018086792 @default.
- W3085505087 hasAuthorship W3085505087A5028812792 @default.
- W3085505087 hasAuthorship W3085505087A5036075244 @default.
- W3085505087 hasAuthorship W3085505087A5038279757 @default.
- W3085505087 hasAuthorship W3085505087A5038755491 @default.
- W3085505087 hasAuthorship W3085505087A5048692547 @default.
- W3085505087 hasAuthorship W3085505087A5054753549 @default.
- W3085505087 hasAuthorship W3085505087A5063525602 @default.
- W3085505087 hasAuthorship W3085505087A5074924251 @default.
- W3085505087 hasAuthorship W3085505087A5083945868 @default.
- W3085505087 hasAuthorship W3085505087A5085975040 @default.