Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085532306> ?p ?o ?g. }
- W3085532306 endingPage "102093" @default.
- W3085532306 startingPage "102093" @default.
- W3085532306 abstract "The purpose was to develop, optimize and assess Self-nanoemulsifying drug delivery system (SNEDDS) to enhance solubility and dissolution rate of the poorly-water soluble Atorvastatin/Ezetimibe (ATV/EZT) combination. The drugs solubility in various excipients was investigated and the combination showed the widest emulsifying region was determined using pseudo ternary phase diagram. Loaded SNEDDS were optimized using Design expert software®, and then investigated for thermodynamic stability, self-emulsification efficiency, cloud point, zeta potential, emulsion nature, loading capacity (LC) and encapsulation efficiency (EE), morphological characteristics and in-vitro release kinetics. The optimized formula dispersed spontaneously forming a thermodynamically stable aqueous nanoemulsion upon dilution with a globule size of 101.3 ± 0.47 nm. Cloud point (80–85 °C) and zeta potential of (−23 mV) indicate nanoemulsion formation at physiological temperature with no chance of separation and low aggregation possibility. Transmission electron microscope image showed nano spherical globules. According to In-vitro release studies, optimized formula showed improved dissolution rate with biphasic pattern where, the burst release phase showed first order kinetic and the gradual release phase showed Korsmeyer–Peppas release kinetic for both drugs. Improved oral bioavailability and greater ability to control serum cholesterol levels using ATV/EZT loaded L-SNEDDs compared to pure drugs suspension were demonstrated through in-vivo studies. SNEEDS were confirmed as a promising approach for enhancing the solubility and dissolution rate of lipophilic ATV/EZT combination compared to pure drugs and marketed product." @default.
- W3085532306 created "2020-09-21" @default.
- W3085532306 creator A5001715635 @default.
- W3085532306 creator A5007603427 @default.
- W3085532306 creator A5034073006 @default.
- W3085532306 creator A5051739624 @default.
- W3085532306 date "2020-12-01" @default.
- W3085532306 modified "2023-10-18" @default.
- W3085532306 title "Design and evaluation of combined atorvastatin and ezetimibe optimized self- nano emulsifying drug delivery system" @default.
- W3085532306 cites W1482561213 @default.
- W3085532306 cites W1810099862 @default.
- W3085532306 cites W1965572011 @default.
- W3085532306 cites W1966990424 @default.
- W3085532306 cites W1969860056 @default.
- W3085532306 cites W1974008347 @default.
- W3085532306 cites W1974702385 @default.
- W3085532306 cites W1979436486 @default.
- W3085532306 cites W1981023155 @default.
- W3085532306 cites W1981081691 @default.
- W3085532306 cites W1981493239 @default.
- W3085532306 cites W1982675616 @default.
- W3085532306 cites W1993789973 @default.
- W3085532306 cites W1994691989 @default.
- W3085532306 cites W2000534554 @default.
- W3085532306 cites W2003952694 @default.
- W3085532306 cites W2012996470 @default.
- W3085532306 cites W2017711000 @default.
- W3085532306 cites W2018343080 @default.
- W3085532306 cites W2021971408 @default.
- W3085532306 cites W2022672711 @default.
- W3085532306 cites W2024734747 @default.
- W3085532306 cites W2025041596 @default.
- W3085532306 cites W2034095303 @default.
- W3085532306 cites W2034496890 @default.
- W3085532306 cites W2036169249 @default.
- W3085532306 cites W2041016731 @default.
- W3085532306 cites W2042058658 @default.
- W3085532306 cites W2045063002 @default.
- W3085532306 cites W2054427301 @default.
- W3085532306 cites W2056209601 @default.
- W3085532306 cites W2056995570 @default.
- W3085532306 cites W2065289570 @default.
- W3085532306 cites W2069983835 @default.
- W3085532306 cites W2075379117 @default.
- W3085532306 cites W2075520799 @default.
- W3085532306 cites W2076863626 @default.
- W3085532306 cites W2077890234 @default.
- W3085532306 cites W2083312474 @default.
- W3085532306 cites W2085731752 @default.
- W3085532306 cites W2085769595 @default.
- W3085532306 cites W2087908293 @default.
- W3085532306 cites W2090485171 @default.
- W3085532306 cites W2100520064 @default.
- W3085532306 cites W2104882286 @default.
- W3085532306 cites W2118184073 @default.
- W3085532306 cites W2130601260 @default.
- W3085532306 cites W2131200221 @default.
- W3085532306 cites W2154862932 @default.
- W3085532306 cites W2155121555 @default.
- W3085532306 cites W2157622195 @default.
- W3085532306 cites W2229685468 @default.
- W3085532306 cites W2253626647 @default.
- W3085532306 cites W2296323608 @default.
- W3085532306 cites W2465758073 @default.
- W3085532306 cites W2478496979 @default.
- W3085532306 cites W2608229004 @default.
- W3085532306 cites W2613271837 @default.
- W3085532306 cites W2769848125 @default.
- W3085532306 cites W2776920687 @default.
- W3085532306 cites W2902975090 @default.
- W3085532306 cites W2915952900 @default.
- W3085532306 cites W332353483 @default.
- W3085532306 cites W53556269 @default.
- W3085532306 cites W65262745 @default.
- W3085532306 doi "https://doi.org/10.1016/j.jddst.2020.102093" @default.
- W3085532306 hasPublicationYear "2020" @default.
- W3085532306 type Work @default.
- W3085532306 sameAs 3085532306 @default.
- W3085532306 citedByCount "21" @default.
- W3085532306 countsByYear W30855323062021 @default.
- W3085532306 countsByYear W30855323062022 @default.
- W3085532306 countsByYear W30855323062023 @default.
- W3085532306 crossrefType "journal-article" @default.
- W3085532306 hasAuthorship W3085532306A5001715635 @default.
- W3085532306 hasAuthorship W3085532306A5007603427 @default.
- W3085532306 hasAuthorship W3085532306A5034073006 @default.
- W3085532306 hasAuthorship W3085532306A5051739624 @default.
- W3085532306 hasConcept C127413603 @default.
- W3085532306 hasConcept C147789679 @default.
- W3085532306 hasConcept C155574463 @default.
- W3085532306 hasConcept C155672457 @default.
- W3085532306 hasConcept C171250308 @default.
- W3085532306 hasConcept C178790620 @default.
- W3085532306 hasConcept C181389837 @default.
- W3085532306 hasConcept C185592680 @default.
- W3085532306 hasConcept C187530423 @default.
- W3085532306 hasConcept C192562407 @default.
- W3085532306 hasConcept C22673317 @default.